rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Further subgroup analysis showed that PD+RBD patients with rs356219/G exhibited a 30% and 20% decreased risk of progression on the H-Y stage and MoCA score (<i>p</i> = 0.038; <i>p</i> = 0.045).
|
31244647 |
2019 |
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the discovery series cohort, we found a 4-loci interaction involving STK11 rs8111699, FCHSD1 rs456998, GSK3B rs1732170, and SNCA rs356219, which was associated with an increased risk of PD (odds ratio = 2.59, P < .001).
|
31234232 |
2019 |
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results indicate that there is a significant association between rs356219 polymorphism and PD susceptibility for all genetic models (allelic: OR = 1.377, 95% CI: 1.275-1.487, p = 0.000; homozygous: OR = 1.958, 95% CI: 1.666-2.301, p = 0.000; heterozygous: OR = 1.261, 95% CI: 1.158-1.373, p = 0.000; dominant: OR = 1.431, 95% CI: 1.320-1.550, p = 0.000; recessive: OR = 1.632, 95% CI: 1.431-1.861, p = 0.000), which is consistent with the results of the subgroup analyses on Asians and Caucasians.
|
31325583 |
2019 |
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The SNCA rs356219-G allele was found to increase the risk of PD in LRRK2 carriers (OR 1.50, 95%CI 1.08-2.01, P = 0.016), and the AAO of AG + GG genotypes was 4 years earlier than AA genotype (P = 0.006).
|
31041581 |
2019 |
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
An association with PD was shown for SNPs rs356219, rs11931074, rs356168.
|
30316070 |
2018 |
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphism rs356219 in the α-synuclein (SNCA) gene has been shown to significantly contribute to an earlier age at onset of Parkinson's disease (PD), and regulates SNCA expression in PD brain regions, blood, and plasma.
|
29505953 |
2018 |
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Additionally, the SHEsis software platform was applied for linkage disequilibrium (LD) analysis between rs356182 and another PD-associated synuclein SNP rs356219 we previously reported.
|
27538639 |
2016 |
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
α-Synuclein rs356219 polymorphisms in patients with Gaucher disease and Parkinson disease.
|
25111979 |
2014 |
rs356219
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Identification of a novel Parkinson's disease locus via stratified genome-wide association study.
|
24511991 |
2014 |
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study provides strong support for the susceptibility role of SNCA rs356219 in sporadic PD in a Han Chinese population from mainland China and the meta-analysis also revealed a similar finding in the Asian population.
|
23737253 |
2013 |
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The additive interactions between SNPs rs356219 and rs356220 and smoking with respect to sporadic PD were significant although the multiplicative interactions were not significant.
|
22425546 |
2012 |
rs356219
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|
22438815 |
2012 |
rs356219
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|
22438815 |
2012 |
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNP rs356219 of the α-synuclein (SNCA) gene is associated with Parkinson's disease in a Chinese Han population.
|
22349157 |
2012 |
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphisms in MAPT (rs1800547; P = 3.1 × 10(-4) ) and SNCA (rs356219; P = 5.5 × 10(-4) ) were significantly associated with Parkinson's disease.
|
21425343 |
2011 |
rs356219
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
|
21292315 |
2011 |
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our findings indicate that as previously reported, the SNCA rs356219-G allele and MAPT rs1052553 (H1 haplotype) were both associated with an increased risk of PD, whilst contrary to previous reports, GSK3B variants were not.
|
21159074 |
2011 |
rs356219
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
|
21292315 |
2011 |
rs356219
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
|
21738487 |
2011 |
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Several markers located across the SNCA gene were associated with PD, including marker alleles associated with disease in previous studies (Rep1 263-bp allele, rs356165 and rs356219).
|
18485051 |
2008 |
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We also performed an association study of the noncoding polymorphisms rs2737029 (A/G) and rs356204 (A/G) (intron 4), and of rs356219 (T/C) (3'-region) of SNCA in a Swedish PD case-control material.
|
18606870 |
2008 |