Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs356219
rs356219
0.900 GeneticVariation BEFREE Further subgroup analysis showed that PD+RBD patients with rs356219/G exhibited a 30% and 20% decreased risk of progression on the H-Y stage and MoCA score (<i>p</i> = 0.038; <i>p</i> = 0.045). 31244647

2019

dbSNP: rs356219
rs356219
0.900 GeneticVariation BEFREE In the discovery series cohort, we found a 4-loci interaction involving STK11 rs8111699, FCHSD1 rs456998, GSK3B rs1732170, and SNCA rs356219, which was associated with an increased risk of PD (odds ratio = 2.59, P < .001). 31234232

2019

dbSNP: rs356219
rs356219
0.900 GeneticVariation BEFREE The results indicate that there is a significant association between rs356219 polymorphism and PD susceptibility for all genetic models (allelic: OR = 1.377, 95% CI: 1.275-1.487, p = 0.000; homozygous: OR = 1.958, 95% CI: 1.666-2.301, p = 0.000; heterozygous: OR = 1.261, 95% CI: 1.158-1.373, p = 0.000; dominant: OR = 1.431, 95% CI: 1.320-1.550, p = 0.000; recessive: OR = 1.632, 95% CI: 1.431-1.861, p = 0.000), which is consistent with the results of the subgroup analyses on Asians and Caucasians. 31325583

2019

dbSNP: rs356219
rs356219
0.900 GeneticVariation BEFREE The SNCA rs356219-G allele was found to increase the risk of PD in LRRK2 carriers (OR 1.50, 95%CI 1.08-2.01, P = 0.016), and the AAO of AG + GG genotypes was 4 years earlier than AA genotype (P = 0.006). 31041581

2019

dbSNP: rs356219
rs356219
0.900 GeneticVariation BEFREE An association with PD was shown for SNPs rs356219, rs11931074, rs356168. 30316070

2018

dbSNP: rs356219
rs356219
0.900 GeneticVariation BEFREE The single-nucleotide polymorphism rs356219 in the α-synuclein (SNCA) gene has been shown to significantly contribute to an earlier age at onset of Parkinson's disease (PD), and regulates SNCA expression in PD brain regions, blood, and plasma. 29505953

2018

dbSNP: rs356219
rs356219
0.900 GeneticVariation BEFREE Additionally, the SHEsis software platform was applied for linkage disequilibrium (LD) analysis between rs356182 and another PD-associated synuclein SNP rs356219 we previously reported. 27538639

2016

dbSNP: rs356219
rs356219
0.900 GeneticVariation BEFREE α-Synuclein rs356219 polymorphisms in patients with Gaucher disease and Parkinson disease. 25111979

2014

dbSNP: rs356219
rs356219
0.900 GeneticVariation GWASDB Identification of a novel Parkinson's disease locus via stratified genome-wide association study. 24511991

2014

dbSNP: rs356219
rs356219
0.900 GeneticVariation BEFREE Our study provides strong support for the susceptibility role of SNCA rs356219 in sporadic PD in a Han Chinese population from mainland China and the meta-analysis also revealed a similar finding in the Asian population. 23737253

2013

dbSNP: rs356219
rs356219
0.900 GeneticVariation BEFREE The additive interactions between SNPs rs356219 and rs356220 and smoking with respect to sporadic PD were significant although the multiplicative interactions were not significant. 22425546

2012

dbSNP: rs356219
rs356219
0.900 GeneticVariation GWASCAT Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815

2012

dbSNP: rs356219
rs356219
0.900 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815

2012

dbSNP: rs356219
rs356219
0.900 GeneticVariation BEFREE SNP rs356219 of the α-synuclein (SNCA) gene is associated with Parkinson's disease in a Chinese Han population. 22349157

2012

dbSNP: rs356219
rs356219
0.900 GeneticVariation BEFREE Single-nucleotide polymorphisms in MAPT (rs1800547; P = 3.1 × 10(-4) ) and SNCA (rs356219; P = 5.5 × 10(-4) ) were significantly associated with Parkinson's disease. 21425343

2011

dbSNP: rs356219
rs356219
G 0.900 GeneticVariation GWASDB Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. 21292315

2011

dbSNP: rs356219
rs356219
0.900 GeneticVariation BEFREE Our findings indicate that as previously reported, the SNCA rs356219-G allele and MAPT rs1052553 (H1 haplotype) were both associated with an increased risk of PD, whilst contrary to previous reports, GSK3B variants were not. 21159074

2011

dbSNP: rs356219
rs356219
G 0.900 GeneticVariation GWASCAT Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. 21292315

2011

dbSNP: rs356219
rs356219
0.900 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487

2011

dbSNP: rs356219
rs356219
0.900 GeneticVariation BEFREE Several markers located across the SNCA gene were associated with PD, including marker alleles associated with disease in previous studies (Rep1 263-bp allele, rs356165 and rs356219). 18485051

2008

dbSNP: rs356219
rs356219
0.900 GeneticVariation BEFREE We also performed an association study of the noncoding polymorphisms rs2737029 (A/G) and rs356204 (A/G) (intron 4), and of rs356219 (T/C) (3'-region) of SNCA in a Swedish PD case-control material. 18606870

2008