|
rs7639352
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two of the risk SNPs (rs266729 and rs182052) plus four other SNPs (rs16861209, rs17366568, rs3774261, and rs7639352) were also associated with plasma adiponectin levels, and three of these (rs1686109, rs17366568, and rs3774261) were also significantly associated with IR expression in prostate tumor tissue.
|
21960694 |
2011 |
|
rs1512268
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genome-wide association studies (GWAS) identified multiple susceptible loci for prostate cancer (PC), and recent GWAS implicated that a common variant rs1512268 on chromosome 8p21 is associated with PC susceptibility, which is located at 14 kb downstream of a prostate tumor suppressor gene NKX3.1.
|
20716579 |
2010 |
|
rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the course of modeling malignant melanoma in a tyrosinase promoter transgenic system, we developed a genetically-engineered mouse (GEM) model of invasive prostate cancers, whereby an activating mutation of BRAF(V6</span>00E)--a mutation found in approximately 10% of human prostate tumors--was targeted to the epithelial compartment of the prostate gland on the background of Ink4a/Arf deficiency.
|
19079609 |
2008 |
|
rs121913377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the course of modeling malignant melanoma in a tyrosinase promoter transgenic system, we developed a genetically-engineered mouse (GEM) model of invasive prostate cancers, whereby an activating mutation of BRAF(V6</span>00E)--a mutation found in approximately 10% of human prostate tumors--was targeted to the epithelial compartment of the prostate gland on the background of Ink4a/Arf deficiency.
|
19079609 |
2008 |
|
rs976306779
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In our study, we evaluated the functional significance of S100P expression on prostate tumor growth in vitro and in vivo.
|
18452169 |
2008 |
|
rs1571801
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of the distribution of these SNPs among 1032 prostate cancer patients and 571 control subjects of European descent indicated that one, rs1571801, located in the DAB2IP gene, which encodes a novel Ras GTPase-activating protein and putative prostate tumor suppressor, was associated with aggressive prostate cancer (one-sided P value = .004).
|
18073375 |
2007 |
|
rs28909982
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we have identified two novel somatic CHEK2 mutations, c.349A > G (p.R117G) and c.967A > C (p.E321K), in prostate tumor specimens and investigated the functions of these mutants in vivo.
|
16835864 |
2006 |
|
rs587782480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we have identified two novel somatic CHEK2 mutations, c.349A > G (p.R117G) and c.967A > C (p.E321K), in prostate tumor specimens and investigated the functions of these mutants in vivo.
|
16835864 |
2006 |
|
rs786202601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we have identified two novel somatic CHEK2 mutations, c.349A > G (p.R117G) and c.967A > C (p.E321K), in prostate tumor specimens and investigated the functions of these mutants in vivo.
|
16835864 |
2006 |
|
rs137852581
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CWR22Rv1 (22Rv1) is an androgen-responsive human prostate carcinoma cell line derived from a primary prostate tumor that expresses mutant (H874Y) androgen receptors (AR) and secretes low levels of prostate specific antigen (PSA).
|
15249132 |
2004 |