|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Case-control analysis revealed an association of IL12B rs3212227 and IL23R rs11209026 minor allele carrier status with reduced odds for psoriasis (OR = 0.66, 95%CI: 0.50-0.87, and OR = 0.41, 95%CI: 0.26-0.67, respectively), while HLA-C*06 allele carriers were more frequent in patients group (OR = 4.56, 95%CI: 3.41-6.10).
|
29454820 |
2018 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Although there was no significant association found between rs610604 (IL12B) and rs11209026 (IL23R) in this population, the interaction of these two genes showed a significant association with psoriasis (P-value: 0.025).
|
25406098 |
2015 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
|
25574825 |
2015 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This study aims to assess whether the association between the non-susceptibility allelic variants of IL12B single-nucleotide polymorphism (SNPs) rs3212227 and rs6887695, IL23R SNPs rs11209026 and rs7530511, IL6 SNP rs1800795 and HLA-Cw6 could be correlated with decreased risk for psoriasis.
|
24140476 |
2014 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study showed significant associations between psoriasis and both IL12B gene SNPs, rs3212227 (odds ratio (OR) = 1.35, P = 4.94E-04) and rs6887695 (OR = 1.32, P = 2.00E-03), but no significant association between psoriasis and the IL23R SNP, rs11209026.
|
23955419 |
2013 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We and others have shown that the minor, nonconserved allele Gln381 of the Arg381Gln single-nucleotide polymorphism (rs11209026G>A) of the IL-23 receptor gene (IL23R) protects against psoriasis.
|
23563201 |
2013 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis showed that the IL-23 R (rs11209026 and rs7530511) polymorphisms are associated with psoriasis risk in Europeans and that the IL-12B (rs6887695 and rs3212227) polymorphisms are associated with susceptibility to psoriasis in Europeans.
|
23844553 |
2013 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We and others have shown that the minor, nonconserved allele Gln381 of the Arg381Gln single-nucleotide polymorphism (rs11209026G>A) of the IL-23 receptor gene (IL23R) protects against psoriasis.
|
23563201 |
2013 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For rs11209026, the odds ratios (ORs) of minor alleles for psoriasis and PsA were 0.616 [95 % confidence interval (CI) 0.563-0.674] and 0.630 (95 % CI 0.524-0.757), respectively.
|
22706445 |
2012 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ankylosing spondylitis.
|
21364948 |
2011 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rare allele of a non-synonymous interleukin 23 receptor (IL23R) single nucleotide polymorphism (SNP) rs11209026 (p.Arg381Gln) confers strong protection against Crohn disease (CD) and psoriasis.
|
18647855 |
2009 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We replicated the previously reported association with interleukin 23 receptor and interleukin 12B (IL12B) polymorphisms in PS and PSA cohorts (IL23R: rs11209026, U.S. PS, P = 1.4x10(-4); U.K. PSA: P = 8.0x10(-4); IL12B:rs6887695, U.S. PS, P = 5x10(-5) and U.K. PSA, P = 1.3x10(-3)) and detected an independent association in the IL23R region with a SNP 4 kb upstream from IL12RB2 (P = 0.001).
|
18369459 |
2008 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A recent study reported that psoriasis was associated with the IL12B haplotype rs3212227 (3'-untranslated region)-rs6887695 (60 kb, 5') and the IL23R haplotype rs7530511 (L310P)-rs11209026 (Q381R).
|
18219280 |
2008 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent studies have shown that a nonsynonymous single-nucleotide polymorphism (SNP) (Arg381Gln; rs11209026) in the interleukin-23 receptor (IL-23R) gene on chromosome 1p31 is associated with Crohn's disease and psoriasis.
|
18383363 |
2008 |
|
rs20541
|
|
|
0.860 |
GeneticVariation |
BEFREE |
In contrast, the lack of any association between rs20541 (IL13) and psoriasis in our Egyptian cohort suggests the existence of important inter-ethnic genetic differences in psoriasis susceptibility.
|
25406098 |
2015 |
|
rs20541
|
|
G |
0.860 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.
|
25903422 |
2015 |
|
rs20541
|
|
G |
0.860 |
GeneticVariation |
GWASCAT |
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
|
26626624 |
2015 |
|
rs610604
|
|
|
0.860 |
GeneticVariation |
BEFREE |
The results demonstrated that the SNPs rs610604 and rs17728338 of the TNFAIP3 and TNIP1 genes, respectively, were associated with psoriasis in our population at both allelic and genotypic levels.
|
26738398 |
2015 |
|
rs610604
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Genome-wide association studies in white and Chinese Han populations have found that the single-nucleotide polymorphism (SNP) rs610604, at the tumour necrosis factor (TNF)-α-induced protein 3 (TNFAIP3) locus, is associated with psoriasis, and is also associated with response to TNF blockade in psoriasis.
|
25496073 |
2015 |
|
rs610604
|
|
G |
0.860 |
GeneticVariation |
GWASCAT |
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
|
26626624 |
2015 |
|
rs610604
|
|
|
0.860 |
GeneticVariation |
BEFREE |
We found a significant association between psoriasis and the single-nucleotide polymorphism rs610604, within the TNFAIP3 gene.
|
25406098 |
2015 |
|
rs610604
|
|
|
0.860 |
GeneticVariation |
BEFREE |
The results demonstrated that SNPs rs2395029, rs17728338 and rs610604 from the HCP5, TNIP1 and TNFAIP3 genes, respectively, were associated with psoriasis in the studied population at both genotype level and allelic level (P < 0.05).
|
25264125 |
2014 |
|
rs20541
|
|
|
0.860 |
GeneticVariation |
BEFREE |
In subgroup analyses, the two SNPs were significantly associated (P < 0.05) with type I psoriasis, Rs495337 showed statistically difference between positive family history of psoriasis patients and controls whereas rs20541 might preferentially associated with negative family history psoriasis patients.
|
23617596 |
2013 |