rs121917737
|
|
|
0.010 |
GeneticVariation |
BEFREE |
G231V and F198S mutations in surfactant protein A2 (SP-A2) are associated with familial pulmonary fibrosis.
|
30293573 |
2018 |
rs11575937
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A clinical picture related to the LMNA Arg482Gln mutation may be more diversified than it was previously considered and include low BMI and pulmonary fibrosis.
|
19859838 |
2009 |
rs2241718
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A functional polymorphism (Q705K; rs35829419) in the NLRP3 gene was associated with interstitial lung fibrosis (p=0.013), and the TGFB1 rs2241718 SNP with visceral pleural fibrosis (VPF) (p=0.044).
|
24142982 |
2014 |
rs35705950
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism (rs35705950) in the mucin 5B (<i>MUC5B</i>) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects.
|
29440587 |
2018 |
rs35705950
|
|
|
0.050 |
GeneticVariation |
BEFREE |
After adjustment for covariates, for each copy of the minor rs35705950 allele, the odds of interstitial lung abnormalities were 2.8 times greater (95% confidence interval [CI], 2.0 to 3.9; P<0.001), and the odds of definite CT evidence of pulmonary fibrosis were 6.3 times greater (95% CI, 3.1 to 12.7; P<0.001).
|
23692170 |
2013 |
rs2004640
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among eight SSc-associated susceptibility polymorphisms which were applied for meta-analysis, IRF5 rs2004640 polymorphism (OR 1.12; 95% CI 1.02-1.22, P = 1.39 × 10<sup>-2</sup>), STAT4 rs7574865 polymorphism (OR 1.25; 95% CI 1.07-1.47, P = 5.3 × 10<sup>-3</sup>), IRAK1 rs1059702 polymorphism (OR 1.20; 95% CI 1.05-1.37, P = 0.007), and CTGF G-945C polymorphism (OR 1.42; 95% CI 1.18-1.71, P = 0.002) are associated with PF status in SSc, while TNFAIP3 rs5029939, CD226 rs763361, CD247 rs2056626, and IRF5 rs10488631 polymorphisms are not.
|
28434122 |
2017 |
rs7574865
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among eight SSc-associated susceptibility polymorphisms which were applied for meta-analysis, IRF5 rs2004640 polymorphism (OR 1.12; 95% CI 1.02-1.22, P = 1.39 × 10<sup>-2</sup>), STAT4 rs7574865 polymorphism (OR 1.25; 95% CI 1.07-1.47, P = 5.3 × 10<sup>-3</sup>), IRAK1 rs1059702 polymorphism (OR 1.20; 95% CI 1.05-1.37, P = 0.007), and CTGF G-945C polymorphism (OR 1.42; 95% CI 1.18-1.71, P = 0.002) are associated with PF status in SSc, while TNFAIP3 rs5029939, CD226 rs763361, CD247 rs2056626, and IRF5 rs10488631 polymorphisms are not.
|
28434122 |
2017 |
rs1059702
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among eight SSc-associated susceptibility polymorphisms which were applied for meta-analysis, IRF5 rs2004640 polymorphism (OR 1.12; 95% CI 1.02-1.22, P = 1.39 × 10<sup>-2</sup>), STAT4 rs7574865 polymorphism (OR 1.25; 95% CI 1.07-1.47, P = 5.3 × 10<sup>-3</sup>), IRAK1 rs1059702 polymorphism (OR 1.20; 95% CI 1.05-1.37, P = 0.007), and CTGF G-945C polymorphism (OR 1.42; 95% CI 1.18-1.71, P = 0.002) are associated with PF status in SSc, while TNFAIP3 rs5029939, CD226 rs763361, CD247 rs2056626, and IRF5 rs10488631 polymorphisms are not.
|
28434122 |
2017 |
rs2004640
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis.
|
19116937 |
2009 |
rs121917738
|
|
|
0.010 |
GeneticVariation |
BEFREE |
G231V and F198S mutations in surfactant protein A2 (SP-A2) are associated with familial pulmonary fibrosis.
|
30293573 |
2018 |
rs34794968
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, haplotype block analysis revealed a significant association for the TCG haplotype (SNP order: rs763361, rs34794968, rs727088) with lung fibrosis positive patients (PBonf = 3.18E-02 OR 1.27 (1.05 to 1.54)).
|
22531499 |
2012 |
rs727088
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, haplotype block analysis revealed a significant association for the TCG haplotype (SNP order: rs763361, rs34794968, rs727088) with lung fibrosis positive patients (PBonf = 3.18E-02 OR 1.27 (1.05 to 1.54)).
|
22531499 |
2012 |
rs1800470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In subgroup analyses by ethnicity or original disease, no statistically significant association between TGF-β1 rs1800470 polymorphisms and PF was demonstrated.This meta-analysis revealed that TGF-β1 rs1800470 polymorphism was not associated with susceptibility to PF development.
|
30212926 |
2018 |
rs3917200
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, there is evidence that rs3917200 is involved in the development of lung </span>fibrosis</span> in sarcoidosis.
|
21148227 |
2011 |
rs1059702
|
|
|
0.020 |
GeneticVariation |
BEFREE |
On the other hand, IRAK1 rs1059702 was consistently associated with presence of pulmonary fibrosis (PF), because statistical significance was observed when comparing SSc patients PF+ versus controls (PFDR=0.039, OR=1.30, 95% CI 1.07 to 1.58) and SSc patients PF+ versus SSc patients PF- (p=0.025, OR=1.26, 95% CI 1.03 to 1.55).
|
23444193 |
2013 |
rs2910164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results also suggested that miR-146a rs2910164 CC genotype may be predisposing factor for development lung fibrosis and more progressive form of SSc.
|
30308218 |
2018 |
rs35829419
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results support the hypothesis that the NLRP3 inflammasome is important in the development of fibrotic lung disease by associating the NLRP3 rs35829419 variant allele with increased risk of asbestos-related interstitial lung fibrosis, and the TGFB1 rs2241718 variant allele with decreased risk of asbestos-related VPF.
|
24142982 |
2014 |
rs1433372015
|
|
|
0.010 |
GeneticVariation |
BEFREE |
STING N153S mice were highly vulnerable to infection and developed pulmonary fibrosis after infection.
|
30463976 |
2019 |
rs587777609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
STING N153S mice were highly vulnerable to infection and developed pulmonary fibrosis after infection.
|
30463976 |
2019 |
rs2276109
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The MMP-12 rs2276109 gene polymorphism may contribute to susceptibility to SSc, and in particular to dcSSc and pulmonary fibrosis.
|
20595276 |
2010 |
rs2034650
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP in IVD (chromosome15, rs2034650) was significantly associated with pulmonary fibrosis in both the Mexican (OR = 0.40, P = .01) and Korean (OR = 0.13, P = .0008) cohorts.
|
25275363 |
2015 |
rs7574865
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The T-allele carriers of rs7574865 and rs10168266 were strongly associated with the presence of anti-topoisomerase I (ATA) and pulmonary fibrosis in SSc patients, as well as with diffuse cutaneous SSc (dcSSc).
|
23755762 |
2013 |
rs10168266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T-allele carriers of rs7574865 and rs10168266 were strongly associated with the presence of anti-topoisomerase I (ATA) and pulmonary fibrosis in SSc patients, as well as with diffuse cutaneous SSc (dcSSc).
|
23755762 |
2013 |
rs652438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no association of MMP-9(-1562T) and MMP-12(Asn357Ser) polymorphisms with lung fibrosis.
|
20392358 |
2010 |
rs35705950
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To determine the effect of the MUC5B promoter polymorphism (rs35705950) on the CT imaging appearance of pulmonary fibrosis.
|
26836909 |
2016 |