Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2004640
rs2004640
0.020 GeneticVariation BEFREE SSc patients of Han Chinese showed increased homozygous TT genotype of the rs2004640 (p = 0.027, odds ratio (OR) = 1.4, CI =1.03-1.93), which was significantly associated with pulmonary fibrosis of SSc and ATA-positive SSc of Han Chinese. 25572744

2015

dbSNP: rs35705950
rs35705950
0.020 GeneticVariation BEFREE After adjustment for covariates, for each copy of the minor rs35705950 allele, the odds of interstitial lung abnormalities were 2.8 times greater (95% confidence interval [CI], 2.0 to 3.9; P<0.001), and the odds of definite CT evidence of pulmonary fibrosis were 6.3 times greater (95% CI, 3.1 to 12.7; P<0.001). 23692170

2013

dbSNP: rs35705950
rs35705950
0.020 GeneticVariation BEFREE To determine whether the MUC5B promoter polymorphism (rs35705950), previously reported to be associated with the development of pulmonary fibrosis, is associated with survival in IPF. 23695349

2013

dbSNP: rs2004640
rs2004640
0.020 GeneticVariation BEFREE Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis. 19116937

2009

dbSNP: rs2609255
rs2609255
0.010 GeneticVariation BEFREE Two recent genome-wide association studies (GWASs) reported that the FAM13A gene at the 4q22 locus associated with pulmonary fibrosis (defined by rs2609255) overlapping with COPD (defined by rs6837671). 29621588

2018

dbSNP: rs6837671
rs6837671
0.010 GeneticVariation BEFREE Two recent genome-wide association studies (GWASs) reported that the FAM13A gene at the 4q22 locus associated with pulmonary fibrosis (defined by rs2609255) overlapping with COPD (defined by rs6837671). 29621588

2018

dbSNP: rs2034650
rs2034650
IVD
0.010 GeneticVariation BEFREE The SNP in IVD (chromosome15, rs2034650) was significantly associated with pulmonary fibrosis in both the Mexican (OR = 0.40, P = .01) and Korean (OR = 0.13, P = .0008) cohorts. 25275363

2015

dbSNP: rs1059702
rs1059702
0.010 GeneticVariation BEFREE On the other hand, IRAK1 rs1059702 was consistently associated with presence of pulmonary fibrosis (PF), because statistical significance was observed when comparing SSc patients PF+ versus controls (PFDR=0.039, OR=1.30, 95% CI 1.07 to 1.58) and SSc patients PF+ versus SSc patients PF- (p=0.025, OR=1.26, 95% CI 1.03 to 1.55). 23444193

2014

dbSNP: rs10168266
rs10168266
0.010 GeneticVariation BEFREE The T-allele carriers of rs7574865 and rs10168266 were strongly associated with the presence of anti-topoisomerase I (ATA) and pulmonary fibrosis in SSc patients, as well as with diffuse cutaneous SSc (dcSSc). 23755762

2013

dbSNP: rs34794968
rs34794968
0.010 GeneticVariation BEFREE However, haplotype block analysis revealed a significant association for the TCG haplotype (SNP order: rs763361, rs34794968, rs727088) with lung fibrosis positive patients (PBonf = 3.18E-02 OR 1.27 (1.05 to 1.54)). 22531499

2013

dbSNP: rs727088
rs727088
0.010 GeneticVariation BEFREE However, haplotype block analysis revealed a significant association for the TCG haplotype (SNP order: rs763361, rs34794968, rs727088) with lung fibrosis positive patients (PBonf = 3.18E-02 OR 1.27 (1.05 to 1.54)). 22531499

2013

dbSNP: rs7574865
rs7574865
0.010 GeneticVariation BEFREE The T-allele carriers of rs7574865 and rs10168266 were strongly associated with the presence of anti-topoisomerase I (ATA) and pulmonary fibrosis in SSc patients, as well as with diffuse cutaneous SSc (dcSSc). 23755762

2013

dbSNP: rs3917200
rs3917200
0.010 GeneticVariation BEFREE Moreover, there is evidence that rs3917200 is involved in the development of lung fibrosis in sarcoidosis. 21148227

2012

dbSNP: rs11575937
rs11575937
0.010 GeneticVariation BEFREE A clinical picture related to the LMNA Arg482Gln mutation may be more diversified than it was previously considered and include low BMI and pulmonary fibrosis. 19859838

2011

dbSNP: rs2276109
rs2276109
0.010 GeneticVariation BEFREE The MMP-12 rs2276109 gene polymorphism may contribute to susceptibility to SSc, and in particular to dcSSc and pulmonary fibrosis. 20595276

2011