rs2070600
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs2070600 SNP may be associated with the development of human autoimmune disease, diabetes complications, cancer, and lung diseases such as chronic obstructive pulmonary disease and acute respiratory distress syndrome.
|
30863465 |
2019 |
rs2070600
|
|
|
0.020 |
GeneticVariation |
BEFREE |
AGER SNP rs2070600 (Ser/Ser) was associated with increased ARDS risk and higher plasma sRAGE in this cohort, although confirmatory studies are needed to assess the role of AGER SNPs in ARDS prediction.
|
29422518 |
2018 |
rs2664581
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results confirm the association between SNP rs2664581 and enhanced risk of ARDS, further supporting the role of PI3 in ARDS development.
|
24617927 |
2014 |
rs315952
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We hypothesized that a synonymous coding variant in the IL-1 receptor antagonist gene (IL1RN), rs315952, previously associated with reduced risk for acute respiratory distress syndrome, would be functional and associate with improved survival in septic shock.
|
25089931 |
2014 |
rs315952
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A total of 12 SNPs met the stage I threshold for an association with ARDS. rs315952 in the IL1RN gene encoding IL-1 receptor antagonist (IL1RA) replicated its association with reduced ARDS risk in stages II (P < 0.004) and III (P < 0.02), and was robust to clinical adjustment (combined odds ratio = 0.81; P = 4.2 × 10(-5)).
|
23449693 |
2013 |
rs2664581
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that the variant allele of rs2664581 (T34P) was significantly associated with increased ARDS risk (odds ratio [OR], 1.35; 95% confidence interval [CI], 1.09-1.67; P = 0.006; false discovery rate adjusted P = 0.018).
|
19251943 |
2009 |
rs2664581
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Patients with ARDS homozygous for the wild-type A allele of rs2664581</span> showed significant lower PI3 plasma level (P = 0.019) at ARDS onset as compared with those homozygous or heterozygous for the variant C allele.
|
19251943 |
2009 |
rs11362
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HBD-1 gene rs1799946 and rs11362 gene mutations were not risk factors for ARDS (P > .05).
|
30702566 |
2019 |
rs121434431
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report three unrelated children with influenza A virus (IAV) infection manifesting as acute respiratory distress syndrome (IAV-ARDS), heterozygous for rare <i>TLR3</i> variants (P554S in two patients and P680L in the third) causing autosomal dominant (AD) TLR3 deficiency.
|
31217193 |
2019 |
rs1799946
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HBD-1 gene rs1799946 and rs11362 gene mutations were not risk factors for ARDS (P > .05).
|
30702566 |
2019 |
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TNF-α rs1800629 locus A allele and the IL-6 rs1800796 locus G allele were found to be risk factors for ARDS (adjusted OR = 1.452, 95% CI: 1.211-1.689, P < .001 and adjusted OR = 1.205, 95% CI: 1.058-1.358, P = .005, respectively).
|
31261506 |
2019 |
rs1800796
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TNF-α rs1800629 locus A allele and the IL-6 rs1800796 locus G allele were found to be risk factors for ARDS (adjusted OR = 1.452, 95% CI: 1.211-1.689, P < .001 and adjusted OR = 1.205, 95% CI: 1.058-1.358, P = .005, respectively).
|
31261506 |
2019 |
rs1800972
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1800972</span> locus G allele carriers are more likely to develop ARDS and have a poor prognosis.
|
30702566 |
2019 |
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggested that two functional polymorphisms of IL-17, rs2275913 and rs8193036 were associated with ARDS risk and prognosis, indicating that the two genetic variants might act as possible markers for the prediction of ARDS risk and development.
|
30655311 |
2019 |
rs3774934
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The IL-17 rs763780 and NF-κB1 rs3774934 SNPs had no impact on ARDS risk and prognosis of ARDS (<i>P</i>>0.05).
|
30655311 |
2019 |
rs763780
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The IL-17 rs763780 and NF-κB1 rs3774934 SNPs had no impact on ARDS risk and prognosis of ARDS (<i>P</i>>0.05).
|
30655311 |
2019 |
rs7744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele at MyD88 rs7744 locus was a protective factor against ARDS (adjusted OR = 0.748, 95% CI: 0.631-0.876, P < .001).
|
31261506 |
2019 |
rs8193036
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggested that two functional polymorphisms of IL-17, rs2275913 and rs8193036 were associated with ARDS</span> risk and prognosis, indicating that the two genetic variants might act as possible markers for the prediction of ARDS risk and development.
|
30655311 |
2019 |
rs151139112
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In silico investigation of the molecular effects caused by R123H variant in secretory phospholipase A2-IIA associated with ARDS.
|
29529495 |
2018 |
rs34568801
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In silico investigation of the molecular effects caused by R123H variant in secretory phospholipase A2-IIA associated with ARDS.
|
29529495 |
2018 |
rs832582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings show a robust association between the variant allele of rs832582 (MAP3K1<sub>906Val</sub>) and decreased VFDs in patients with ARDS and suggest that this variant may predispose individuals to a greater inflammatory response.
|
28858533 |
2018 |
rs4957796
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, FER rs4957796 might act as a prognostic variable for survival in patients with severe ARDS due to pneumonia.
|
28851893 |
2017 |
rs516651
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>PHD2</i> rs516651 TT-genotype in ARDS was independently associated with a 3.34 times greater mortality risk (OR 3.34, CI 1.09-10.22; <i>p</i> = 0.034) within 30-days, whereas the other SNPs had no significant impact (<i>p</i> = ns).
|
28613249 |
2017 |
rs10905928
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the African American group multivariable analysis indicated that three variants in CELF2, rs7068124 (p = 0.004), rs3814634 (p = 0.032) and rs10905928 (p = 0.044), and two in TIA1, rs2592178 (p = 0.005) and rs13402990 (p = 0.018) were independently associated with ARDS.
|
27596159 |
2016 |
rs117603931
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our objective was to functionally characterize two ABCA3 mutations (p.R288K and p.R1474W) identified among term and late-preterm infants with respiratory distress syndrome with unclear pathogenicity in a genetically versatile model system.
|
27374344 |
2016 |