Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2070600
rs2070600
0.020 GeneticVariation BEFREE The rs2070600 SNP may be associated with the development of human autoimmune disease, diabetes complications, cancer, and lung diseases such as chronic obstructive pulmonary disease and acute respiratory distress syndrome. 30863465

2019

dbSNP: rs2070600
rs2070600
0.020 GeneticVariation BEFREE AGER SNP rs2070600 (Ser/Ser) was associated with increased ARDS risk and higher plasma sRAGE in this cohort, although confirmatory studies are needed to assess the role of AGER SNPs in ARDS prediction. 29422518

2018

dbSNP: rs2664581
rs2664581
PI3
0.020 GeneticVariation BEFREE Our results confirm the association between SNP rs2664581 and enhanced risk of ARDS, further supporting the role of PI3 in ARDS development. 24617927

2014

dbSNP: rs315952
rs315952
0.020 GeneticVariation BEFREE We hypothesized that a synonymous coding variant in the IL-1 receptor antagonist gene (IL1RN), rs315952, previously associated with reduced risk for acute respiratory distress syndrome, would be functional and associate with improved survival in septic shock. 25089931

2014

dbSNP: rs315952
rs315952
0.020 GeneticVariation BEFREE A total of 12 SNPs met the stage I threshold for an association with ARDS. rs315952 in the IL1RN gene encoding IL-1 receptor antagonist (IL1RA) replicated its association with reduced ARDS risk in stages II (P < 0.004) and III (P < 0.02), and was robust to clinical adjustment (combined odds ratio = 0.81; P = 4.2 × 10(-5)). 23449693

2013

dbSNP: rs2664581
rs2664581
PI3
0.020 GeneticVariation BEFREE We found that the variant allele of rs2664581 (T34P) was significantly associated with increased ARDS risk (odds ratio [OR], 1.35; 95% confidence interval [CI], 1.09-1.67; P = 0.006; false discovery rate adjusted P = 0.018). 19251943

2009

dbSNP: rs2664581
rs2664581
PI3
0.020 GeneticVariation BEFREE Patients with ARDS homozygous for the wild-type A allele of rs2664581</span> showed significant lower PI3 plasma level (P = 0.019) at ARDS onset as compared with those homozygous or heterozygous for the variant C allele. 19251943

2009

dbSNP: rs11362
rs11362
0.010 GeneticVariation BEFREE HBD-1 gene rs1799946 and rs11362 gene mutations were not risk factors for ARDS (P > .05). 30702566

2019

dbSNP: rs121434431
rs121434431
0.010 GeneticVariation BEFREE We report three unrelated children with influenza A virus (IAV) infection manifesting as acute respiratory distress syndrome (IAV-ARDS), heterozygous for rare <i>TLR3</i> variants (P554S in two patients and P680L in the third) causing autosomal dominant (AD) TLR3 deficiency. 31217193

2019

dbSNP: rs1799946
rs1799946
0.010 GeneticVariation BEFREE HBD-1 gene rs1799946 and rs11362 gene mutations were not risk factors for ARDS (P > .05). 30702566

2019

dbSNP: rs1800629
rs1800629
TNF
0.010 GeneticVariation BEFREE The TNF-α rs1800629 locus A allele and the IL-6 rs1800796 locus G allele were found to be risk factors for ARDS (adjusted OR = 1.452, 95% CI: 1.211-1.689, P < .001 and adjusted OR = 1.205, 95% CI: 1.058-1.358, P = .005, respectively). 31261506

2019

dbSNP: rs1800796
rs1800796
0.010 GeneticVariation BEFREE The TNF-α rs1800629 locus A allele and the IL-6 rs1800796 locus G allele were found to be risk factors for ARDS (adjusted OR = 1.452, 95% CI: 1.211-1.689, P < .001 and adjusted OR = 1.205, 95% CI: 1.058-1.358, P = .005, respectively). 31261506

2019

dbSNP: rs1800972
rs1800972
0.010 GeneticVariation BEFREE The rs1800972</span> locus G allele carriers are more likely to develop ARDS and have a poor prognosis. 30702566

2019

dbSNP: rs2275913
rs2275913
0.010 GeneticVariation BEFREE Our results suggested that two functional polymorphisms of IL-17, rs2275913 and rs8193036 were associated with ARDS risk and prognosis, indicating that the two genetic variants might act as possible markers for the prediction of ARDS risk and development. 30655311

2019

dbSNP: rs3774934
rs3774934
0.010 GeneticVariation BEFREE The IL-17 rs763780 and NF-κB1 rs3774934 SNPs had no impact on ARDS risk and prognosis of ARDS (<i>P</i>>0.05). 30655311

2019

dbSNP: rs763780
rs763780
0.010 GeneticVariation BEFREE The IL-17 rs763780 and NF-κB1 rs3774934 SNPs had no impact on ARDS risk and prognosis of ARDS (<i>P</i>>0.05). 30655311

2019

dbSNP: rs7744
rs7744
0.010 GeneticVariation BEFREE The G allele at MyD88 rs7744 locus was a protective factor against ARDS (adjusted OR = 0.748, 95% CI: 0.631-0.876, P < .001). 31261506

2019

dbSNP: rs8193036
rs8193036
0.010 GeneticVariation BEFREE Our results suggested that two functional polymorphisms of IL-17, rs2275913 and rs8193036 were associated with ARDS</span> risk and prognosis, indicating that the two genetic variants might act as possible markers for the prediction of ARDS risk and development. 30655311

2019

dbSNP: rs151139112
rs151139112
0.010 GeneticVariation BEFREE In silico investigation of the molecular effects caused by R123H variant in secretory phospholipase A2-IIA associated with ARDS. 29529495

2018

dbSNP: rs34568801
rs34568801
0.010 GeneticVariation BEFREE In silico investigation of the molecular effects caused by R123H variant in secretory phospholipase A2-IIA associated with ARDS. 29529495

2018

dbSNP: rs832582
rs832582
0.010 GeneticVariation BEFREE Our findings show a robust association between the variant allele of rs832582 (MAP3K1<sub>906Val</sub>) and decreased VFDs in patients with ARDS and suggest that this variant may predispose individuals to a greater inflammatory response. 28858533

2018

dbSNP: rs4957796
rs4957796
FER
0.010 GeneticVariation BEFREE In conclusion, FER rs4957796 might act as a prognostic variable for survival in patients with severe ARDS due to pneumonia. 28851893

2017

dbSNP: rs516651
rs516651
0.010 GeneticVariation BEFREE <i>PHD2</i> rs516651 TT-genotype in ARDS was independently associated with a 3.34 times greater mortality risk (OR 3.34, CI 1.09-10.22; <i>p</i> = 0.034) within 30-days, whereas the other SNPs had no significant impact (<i>p</i> = ns). 28613249

2017

dbSNP: rs10905928
rs10905928
0.010 GeneticVariation BEFREE In the African American group multivariable analysis indicated that three variants in CELF2, rs7068124 (p = 0.004), rs3814634 (p = 0.032) and rs10905928 (p = 0.044), and two in TIA1, rs2592178 (p = 0.005) and rs13402990 (p = 0.018) were independently associated with ARDS. 27596159

2016

dbSNP: rs117603931
rs117603931
0.010 GeneticVariation BEFREE Our objective was to functionally characterize two ABCA3 mutations (p.R288K and p.R1474W) identified among term and late-preterm infants with respiratory distress syndrome with unclear pathogenicity in a genetically versatile model system. 27374344

2016