The rs9568036 polymorphism in the <i>RB1</i> gene and the allelic variants can be associated with type of response to medical therapy and associated with male sex, while the allelic variant rs1042522 polymorphism in the <i>TP53</i> gene is associated with the unilateral presentation of the disease in a group of Mexican children with RB.
However, the rs1042</span>522 GC genotype showed a protective effect against RB invasion, as demonstrated by event-free survival (HR = 0.53, P = 0.007 for GC versus GG/CC).