|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We found no significant association for either the polymorphism rs4986790 or rs4986791 with sepsis susceptibility in total analysis under any genetic models.
|
27958344 |
2016 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis.
|
25454804 |
2015 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively).
|
25427560 |
2015 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis.
|
21968286 |
2012 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The odds ratio for the association of Asp299Gly polymorphism with sepsis</span> risk was 1.22 (95% CI: 0.90-1.65, P=0.21), and the association of Thr399Ile polymorphism was 1.16 (95%CI: 0.70-1.91, P=0.57).
|
22537674 |
2012 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Six haplotype-tagging SNPs in the TLR4 gene were subsequently examined to analyze their influence on TLR4 A896G SNPs relationship to sepsis severity.
|
19131814 |
2009 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease.
|
18034244 |
2008 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To investigate whether the presence of the TLR4(D299G) mutation may correlate with the development or outcome of sepsis following major visceral surgery the presence of TLR4(D299G) mutation was analysed in 307 Caucasian patients (154 without and 153 with sepsis).
|
12807489 |
2003 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis.
|
12404174 |
2002 |