Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs74799832
rs74799832
RET
0.720 GeneticVariation BEFREE In the present study, we investigated whether the oncogenic RET mutants RET2A (C634R) and RET2B (M918T) were regulated by LRIG1, and the possible effects of LRIG1 expression in thyroid cancer were investigated in three different clinical cohorts and in a RET2B-driven mouse model of MTC. 29436694

2018
dbSNP: rs74799832
rs74799832
RET
0.720 GeneticVariation BEFREE In present result, RET rs1799939, rs1800858 and rs74799832 polymorphisms might be the risk factors for TC. 26191299

2015
dbSNP: rs74799832
rs74799832
RET
C 0.720 CausalMutation CLINVAR Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. 22025146

2012
dbSNP: rs74799832
rs74799832
RET
C 0.720 CausalMutation CLINVAR Thyroid cancer cell lines harboring RET/PTC1 (TPC-1), RET M918T (MZ-CRC1) and RET C634W (TT) alterations, as well as TPC-1 xenografts, were treated with JAK inhibitor, AZD1480. 23056499

2012
dbSNP: rs74799832
rs74799832
RET
C 0.720 CausalMutation CLINVAR Targeted therapies for thyroid tumors. 21455200

2011
dbSNP: rs74799832
rs74799832
RET
C 0.720 CausalMutation CLINVAR The effects of four different tyrosine kinase inhibitors on medullary and papillary thyroid cancer cells. 21470995

2011
dbSNP: rs74799832
rs74799832
RET
C 0.720 CausalMutation CLINVAR Phase II study of daily sunitinib in FDG-PET-positive, iodine-refractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation. 20847059

2010
dbSNP: rs74799832
rs74799832
RET
C 0.720 CausalMutation CLINVAR Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. 20065189

2010
dbSNP: rs74799832
rs74799832
RET
C 0.720 CausalMutation CLINVAR Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer. 20368568

2010
dbSNP: rs74799832
rs74799832
RET
C 0.720 CausalMutation CLINVAR Phase II trial of sorafenib in metastatic thyroid cancer. 19255327

2009
dbSNP: rs74799832
rs74799832
RET
C 0.720 CausalMutation CLINVAR Phase II trial of sorafenib in advanced thyroid cancer. 18541894

2008
dbSNP: rs74799832
rs74799832
RET
C 0.720 CausalMutation CLINVAR Molecular biology of the MEN2 gene. 9681850

1998