rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T polymorphism has been regarded as a risk factor for various vascular diseases.
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30557982 |
2018 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been speculated to be and extensively investigated as a risk factor for various vascular diseases, including intracerebral hemorrhage (ICH).
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26757363 |
2016 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
To investigate the influence of MTHFR polymorphism on vascular disease risks in young Japanese females, we determined dietary intakes, serum folate and tHcy, and examined the influence of MTHFR 677C>T polymorphism in healthy junior and high school students (n=192, 12-18y).
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22507617 |
2012 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The variant methylenetetrahydrofolate reductase (MTHFR) C677T is associated with elevated homocysteine levels, cardiovascular disease and stroke, which supports a causal relationship between hyperhomocysteinemia and vascular disease.
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23285280 |
2012 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Blood samples from 70 patients with vascular disease and 70 healthy controls were analyzed for plasma homocysteine levels (chemiluminescent immunoassay) and for the presence of MTHFR C677T (polymerase chain reaction analysis).
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22375042 |
2012 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
MTHFR 677C/T polymorphism is associated with the risk of vascular diseases due to hyperhomocysteinemia.
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19646848 |
2009 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Homozygosity for the thermolabile variant of 5,10-methylene tetrahydrofolate reductase (C677T) has been suggested to be positively associated with the risk of vascular disease and neural tube defects.
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17010581 |
2007 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Mutations or polymorphisms in the gene of the enzyme methylenetetrahydrofolate reductase (MTHFR), as C677T, A1298C and G1793A, are associated with hyperhomocysteinemia and possibly with elevated risk for vascular diseases.
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17966140 |
2007 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The C677T substitution variant in the methylenetetrahydrofolate reductase (MTHFR) gene has been associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease.
|
16564429 |
2006 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Two common polymorphisms (677C>T and 1298A>C) in the gene coding for MTHFR have been shown to reduce MTHFR enzyme activity and were associated with the susceptibility to different disorders, including vascular disease, neural tube defects and lymphoid malignancies.
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15921520 |
2005 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
To test whether the T variant of the C677T polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) would associate with three distinct forms of vascular disease, abdominal aortic aneurysm (AAA), coronary artery disease (CAD) and peripheral vascular disease (PVD).
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15996600 |
2005 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene, one of the key enzymes catalyzing remethylation of homocysteine, may play a role in the development of not only vascular disease but also diabetic microangiopathies.
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15126006 |
2004 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease.
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15053827 |
2004 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
We found raised median tHcy levels in all patient groups vs. controls (p < 0.05), with odds ratios (95% CI) for vascular disease among patients with HHcy (defined as > 15 micromol/l) of 3.9 (0.6 - 14.3), 4.8 (1.2 - 18.8) and 15.8 (2.8 - 87.3) respectively. tHcy levels were a function of MTHFR C677T genotype, and all patients with tHcy levels > 30 micromol/l had the MTHFR C677T homozygous substitution.
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14698652 |
2003 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
In the present study, the determinants of fasting plasma homocysteine in diabetic subjects were examined; whether plasma homocysteine and vascular disease are related and the influence of the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene on serum and erythrocyte folate, plasma homocysteine and vascular disease.
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12049616 |
2002 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The C677T polymorphism of the 5,10 methylenetetrahydrofolate reductase (MTHFR) gene is associated with decreased MTHFR activity and elevated plasma homocysteine levels with the result of an increased risk for vascular disease.
|
12052604 |
2002 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The prevalences of the C677T and A1298C genotypes did not differ significantly in 772 individuals with documented coronary artery disease (CAD), 137 individuals with deep-vein thrombosis (DVT), and 329 individuals without documented vascular disease.
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11274015 |
2001 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
A common mutation in methylenetetrahydrofolate reductase (MTHFR), 677C-->T, is associated with reduced enzyme activity, a thermolabile enzyme and mild hyperhomocysteinemia, a risk factor for vascular disease.
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11395038 |
2001 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The total homocysteine (tHcy) plasma level, which is partly determined by the MTHFR 677C-->T genotype, may be associated with vascular disease.
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11169021 |
2001 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The thrombotic risk factors decreased levels of activated protein C resistance ratios and protein C, elevated homocysteine and the MTHFR 677 C-->T mutation are likely risk factors for placental vasculopathy.
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10847236 |
2000 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
This study was undertaken to investigate whether the cytosine-to-thymine substitution at nucleotide 677 (C677T) in the 5, 10-methylenetetrahydrofolate reductase gene is a risk factor for placental vasculopathy (abruptio placentae or placental infarction with fetal growth restriction).
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10819868 |
2000 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Further studies are needed to establish whether the C677T and the A1298C mutations have an impact on vascular disease in the Ashkenazi Jewish population.
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10494095 |
1999 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
However, it is still controversial a direct association between C677T homozygosity and the occurrence of vascular disease is still controversial.
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10477457 |
1999 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Lower levels of dietary folate intake and the C677T mutation in MTHFR are important causes of mild hyperhomocysteinemia and may therefore contribute to vascular disease in the community.
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10318658 |
1999 |
rs1799983
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0.050 |
GeneticVariation |
BEFREE |
The endothelial nitric oxide synthase (eNOS) gene single nucleotide polymorphism G894T is associated with thrombotic vascular diseases.
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25917853 |
2015 |