Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE MTHFR C677T polymorphism has been regarded as a risk factor for various vascular diseases. 30557982

2018

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been speculated to be and extensively investigated as a risk factor for various vascular diseases, including intracerebral hemorrhage (ICH). 26757363

2016

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE To investigate the influence of MTHFR polymorphism on vascular disease risks in young Japanese females, we determined dietary intakes, serum folate and tHcy, and examined the influence of MTHFR 677C>T polymorphism in healthy junior and high school students (n=192, 12-18y). 22507617

2012

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The variant methylenetetrahydrofolate reductase (MTHFR) C677T is associated with elevated homocysteine levels, cardiovascular disease and stroke, which supports a causal relationship between hyperhomocysteinemia and vascular disease. 23285280

2012

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Blood samples from 70 patients with vascular disease and 70 healthy controls were analyzed for plasma homocysteine levels (chemiluminescent immunoassay) and for the presence of MTHFR C677T (polymerase chain reaction analysis). 22375042

2012

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE MTHFR 677C/T polymorphism is associated with the risk of vascular diseases due to hyperhomocysteinemia. 19646848

2009

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Homozygosity for the thermolabile variant of 5,10-methylene tetrahydrofolate reductase (C677T) has been suggested to be positively associated with the risk of vascular disease and neural tube defects. 17010581

2007

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Mutations or polymorphisms in the gene of the enzyme methylenetetrahydrofolate reductase (MTHFR), as C677T, A1298C and G1793A, are associated with hyperhomocysteinemia and possibly with elevated risk for vascular diseases. 17966140

2007

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The C677T substitution variant in the methylenetetrahydrofolate reductase (MTHFR) gene has been associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease. 16564429

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Two common polymorphisms (677C>T and 1298A>C) in the gene coding for MTHFR have been shown to reduce MTHFR enzyme activity and were associated with the susceptibility to different disorders, including vascular disease, neural tube defects and lymphoid malignancies. 15921520

2005

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE To test whether the T variant of the C677T polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) would associate with three distinct forms of vascular disease, abdominal aortic aneurysm (AAA), coronary artery disease (CAD) and peripheral vascular disease (PVD). 15996600

2005

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene, one of the key enzymes catalyzing remethylation of homocysteine, may play a role in the development of not only vascular disease but also diabetic microangiopathies. 15126006

2004

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease. 15053827

2004

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We found raised median tHcy levels in all patient groups vs. controls (p < 0.05), with odds ratios (95% CI) for vascular disease among patients with HHcy (defined as > 15 micromol/l) of 3.9 (0.6 - 14.3), 4.8 (1.2 - 18.8) and 15.8 (2.8 - 87.3) respectively. tHcy levels were a function of MTHFR C677T genotype, and all patients with tHcy levels > 30 micromol/l had the MTHFR C677T homozygous substitution. 14698652

2003

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In the present study, the determinants of fasting plasma homocysteine in diabetic subjects were examined; whether plasma homocysteine and vascular disease are related and the influence of the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene on serum and erythrocyte folate, plasma homocysteine and vascular disease. 12049616

2002

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The C677T polymorphism of the 5,10 methylenetetrahydrofolate reductase (MTHFR) gene is associated with decreased MTHFR activity and elevated plasma homocysteine levels with the result of an increased risk for vascular disease. 12052604

2002

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The prevalences of the C677T and A1298C genotypes did not differ significantly in 772 individuals with documented coronary artery disease (CAD), 137 individuals with deep-vein thrombosis (DVT), and 329 individuals without documented vascular disease. 11274015

2001

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE A common mutation in methylenetetrahydrofolate reductase (MTHFR), 677C-->T, is associated with reduced enzyme activity, a thermolabile enzyme and mild hyperhomocysteinemia, a risk factor for vascular disease. 11395038

2001

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The total homocysteine (tHcy) plasma level, which is partly determined by the MTHFR 677C-->T genotype, may be associated with vascular disease. 11169021

2001

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The thrombotic risk factors decreased levels of activated protein C resistance ratios and protein C, elevated homocysteine and the MTHFR 677 C-->T mutation are likely risk factors for placental vasculopathy. 10847236

2000

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE This study was undertaken to investigate whether the cytosine-to-thymine substitution at nucleotide 677 (C677T) in the 5, 10-methylenetetrahydrofolate reductase gene is a risk factor for placental vasculopathy (abruptio placentae or placental infarction with fetal growth restriction). 10819868

2000

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Further studies are needed to establish whether the C677T and the A1298C mutations have an impact on vascular disease in the Ashkenazi Jewish population. 10494095

1999

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE However, it is still controversial a direct association between C677T homozygosity and the occurrence of vascular disease is still controversial. 10477457

1999

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Lower levels of dietary folate intake and the C677T mutation in MTHFR are important causes of mild hyperhomocysteinemia and may therefore contribute to vascular disease in the community. 10318658

1999

dbSNP: rs1799983
rs1799983
0.050 GeneticVariation BEFREE The endothelial nitric oxide synthase (eNOS) gene single nucleotide polymorphism G894T is associated with thrombotic vascular diseases. 25917853

2015