Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs587781525
rs587781525
A 0.700 CausalMutation CLINVAR Germline TP53 mutations is common in patients with two early-onset primary malignancies. 25293557

2015

dbSNP: rs587781525
rs587781525
C 0.700 CausalMutation CLINVAR Germline TP53 mutations is common in patients with two early-onset primary malignancies. 25293557

2015

dbSNP: rs587781525
rs587781525
C 0.700 CausalMutation CLINVAR High frequency of germline TP53 mutations in a prospective adult-onset sarcoma cohort. 23894400

2013

dbSNP: rs587781525
rs587781525
C 0.700 CausalMutation CLINVAR Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome. 21305319

2011

dbSNP: rs587781525
rs587781525
C 0.700 CausalMutation CLINVAR Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes. 21343334

2011

dbSNP: rs587781525
rs587781525
C 0.700 CausalMutation CLINVAR Oncogenic mutation of the p53 gene derived from head and neck cancer prevents cells from undergoing apoptosis after DNA damage. 17390010

2007

dbSNP: rs587781525
rs587781525
C 0.700 CausalMutation CLINVAR Rapid development of post-radiotherapy sarcoma and breast cancer in a patient with a novel germline 'de-novo' TP53 mutation. 17572079

2007

dbSNP: rs587781525
rs587781525
C 0.700 CausalMutation CLINVAR Identification of five new families strengthens the link between childhood choroid plexus carcinoma and germline TP53 mutations. 15925506

2005

dbSNP: rs587781525
rs587781525
A 0.700 CausalMutation CLINVAR Identification of five new families strengthens the link between childhood choroid plexus carcinoma and germline TP53 mutations. 15925506

2005

dbSNP: rs587781525
rs587781525
A 0.700 CausalMutation CLINVAR Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. 12826609

2003

dbSNP: rs587781525
rs587781525
C 0.700 CausalMutation CLINVAR Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. 12826609

2003

dbSNP: rs587781525
rs587781525
C 0.700 CausalMutation CLINVAR P53 germline mutations in childhood cancers and cancer risk for carrier individuals. 10864200

2000

dbSNP: rs587781525
rs587781525
A 0.700 CausalMutation CLINVAR P53 germline mutations in childhood cancers and cancer risk for carrier individuals. 10864200

2000

dbSNP: rs587781525
rs587781525
C 0.700 CausalMutation CLINVAR p53 mutants without a functional tetramerisation domain are not oncogenic. 10064694

1999