|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
MTHFR gene polymorphisms, the c. 677C>T and c. 1298A>C have been implicated as risk factors for several types of cancers as the acute leukemia.
|
28374953 |
2018 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism.
|
22706675 |
2012 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The MTHFR C677T and A1298C polymorphisms are not significant risk factors in adult acute leukemia in the Korean population.
|
17970089 |
2007 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We retrospectively analyzed the incidence of MTHFR C677T and the influence of genotype on methotrexate (MTX) toxicity in patients with acute leukemia undergoing maintenance chemotherapy.
|
12453860 |
2002 |
|
rs1045642
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our results suggest that the ABCB1 G2677T and C3435T sequence variations may affect susceptibility to acute leukemia.
|
27706688 |
2016 |
|
rs1045642
|
|
|
0.030 |
GeneticVariation |
BEFREE |
ABCB1 3435C > T polymorphisms may be associated with susceptibility to acute leukemia, and ABCB1 polymorphisms might be a sensitive indicator for predicting efficacy of MTX therapy in the treatment of acute leukemia.
|
25921280 |
2015 |
|
rs77375493
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A high JAK2(V617F) allele burden was correlated with the transformation to myelofibrosis (p<0.0001), but not with the transformation to acute leukemia.
|
22818858 |
2013 |
|
rs77375493
|
|
|
0.030 |
GeneticVariation |
BEFREE |
JAK2 V617F mutation was detected after transformation to CMML in 1 of them; in the other, a novel translocation t(5;12)(p13;q24) was observed at the time of progression to acute leukemia.
|
21658659 |
2011 |
|
rs1045642
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Association of an MDR1 gene (C3435T) polymorphism with acute leukemia in India.
|
21133625 |
2010 |
|
rs77375493
|
|
|
0.030 |
GeneticVariation |
BEFREE |
JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia.
|
16037387 |
2005 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism.
|
22706675 |
2012 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The MTHFR C677T and A1298C polymorphisms are not significant risk factors in adult acute leukemia in the Korean population.
|
17970089 |
2007 |
|
rs1799929
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between rs1799929 and decreased AL risk was found in the co-dominant (OR 0.82, 95% CI 0.70-0.97), homozygous (OR 0.65, 95% CI 0.46-0.93), heterozygous (OR 0.71, 95% CI 0.51-1.00), and the recessive model (OR 0.68, 95% CI 0.49-0.94) in the Caucasian group.
|
30896661 |
2019 |
|
rs1801280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs1801280 and the slow acetylator phenotype are risk factors for AL.
|
30896661 |
2019 |
|
rs231775
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eighty-eight children with acute leukemia and their donors were genotyped of CTLA-4 gene for rs231775.
|
30465728 |
2019 |
|
rs8073069
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In survivin, rs8073069C/G may have no correlation with the risk of acute leukemia.
|
29456699 |
2018 |
|
rs9904341
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the SNP of rs9904341C/G in survivin may be correlated with the risk of acute leukemia, and compared with C/C genotype, patients with C/G or G/G may have a decreased risk of acute leukemia.
|
29456699 |
2018 |
|
rs559063155
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patient samples showed SF3B1 K700E mutations within the ptDNA of 4 patients with acute leukemia and 3 with myelodysplastic syndrome who were known to harbor this mutation.
|
28615231 |
2017 |
|
rs62527607
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evaluation of rs62527607 [GT] single nucleotide polymorphism located in BAALC gene in children with acute leukemia using mismatch PCR-RFLP.
|
27372260 |
2017 |
|
rs1057519766
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three out of 14 (21.4 %) C57BL/6J mice transplanted with FLT3-N676K</span>-transduced primary hematopoietic progenitor cells developed acute leukemia (latency of 68, 77, and 273 days), while no hematological malignancy was observed in the control groups including FLT3-ITD.
|
26891877 |
2016 |
|
rs2032582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the ABCB1 G2677T and C3435T sequence variations may affect susceptibility to acute leukemia.
|
27706688 |
2016 |
|
rs2228570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, TT carriers of rs2228570 were closely associated with a poor response to treatment and a higher risk of myelodysplastic syndrome/acute leukemia transformation, while CT carriers more easily evolved to overt paroxysmal nocturnal hemoglobinuria.
|
27018192 |
2016 |
|
rs2295080
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratifying analyses by cancer type, we found that the rs2295080 G allele was associated with a significantly higher risk of acute leukemia in the recessive model (GG versus GT/TT: fixed-effects OR=2.08, 95% CI 1.34-3.22) and a lower risk of genitourinary cancers in the dominant model (TG/GG versus TT: fixed-effects OR=0.77, 95% CI 0.68-0.86).
|
27462867 |
2016 |
|
rs767464424
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three out of 14 (21.4 %) C57BL/6J mice transplanted with FLT3-N676K</span>-transduced primary hematopoietic progenitor cells developed acute leukemia (latency of 68, 77, and 273 days), while no hematological malignancy was observed in the control groups including FLT3-ITD.
|
26891877 |
2016 |
|
rs777017502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three out of 14 (21.4 %) C57BL/6J mice transplanted with FLT3-N676K</span>-transduced primary hematopoietic progenitor cells developed acute leukemia (latency of 68, 77, and 273 days), while no hematological malignancy was observed in the control groups including FLT3-ITD.
|
26891877 |
2016 |