Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs201278114
rs201278114
G 0.700 CausalMutation CLINVAR Postmortem genetic screening for the identification, verification, and reporting of genetic variants contributing to the sudden death of the young. 27435932

2016

dbSNP: rs10500279
rs10500279
0.700 GeneticVariation GWASDB Common variants in RYR1 are associated with left ventricular hypertrophy assessed by electrocardiogram. 21828061

2012

dbSNP: rs2071090
rs2071090
0.700 GeneticVariation GWASDB Common variants in RYR1 are associated with left ventricular hypertrophy assessed by electrocardiogram. 21828061

2012

dbSNP: rs2960321
rs2960321
0.700 GeneticVariation GWASDB Common variants in RYR1 are associated with left ventricular hypertrophy assessed by electrocardiogram. 21828061

2012

dbSNP: rs1436109
rs1436109
0.700 GeneticVariation GWASCAT Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families. 21212386

2011

dbSNP: rs121908596
rs121908596
T 0.700 GeneticVariation CLINVAR Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome. 18042262

2008

dbSNP: rs1060501439
rs1060501439
A 0.700 GeneticVariation CLINVAR

dbSNP: rs397516037
rs397516037
A 0.700 CausalMutation CLINVAR

dbSNP: rs768079285
rs768079285
A 0.700 GeneticVariation CLINVAR

dbSNP: rs869312687
rs869312687
G 0.700 CausalMutation CLINVAR

dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE Angiotensinogen M235T and T174M polymorphisms have individually been associated with elevated levels of plasma angiotensinogen, hypertension, and left ventricular hypertrophy. 17145981

2007

dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE Polymorphism of the AGT M235T gene but not ACE I/D gene is associated with greater LVMi and relative wall thickness, indicating more concentric LVH, in Chinese peritoneal dialysis patients. 12675870

2003

dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE The angiotensinogen T174M and M235T and the AT1-receptor A1166C polymorphisms were related to the change in LVH during antihypertensive treatment with an AT1-receptor antagonist; of these angiotensinogen T174M was the most powerful. 11910301

2002

dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE These results suggest an association of combined angiotensin I-converting enzyme gene I/D polymorphism genotypes, and angiotensinogen gene M235T polymorphism genotypes with left ventricular hypertrophy due to long-term athletic training. 11737220

2001

dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE There are controversies concerning the association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism with left ventricular hypertrophy (LVH), and the unclear association between angiotensinogen (ATG) M235T polymorphism and LVH. 10646957

2000

dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE Angiotensinogen gene M235T polymorphism is associated with the variability in left ventricular hypertrophy induced by endurance training, with athletes homozygous for the T allele having the largest hearts. 10440164

1999

dbSNP: rs1267969615
rs1267969615
ACE
0.050 GeneticVariation BEFREE Polymorphism of the AGT M235T gene but not ACE I/D gene is associated with greater LVMi and relative wall thickness, indicating more concentric LVH, in Chinese peritoneal dialysis patients. 12675870

2003

dbSNP: rs1267969615
rs1267969615
ACE
0.050 GeneticVariation BEFREE The angiotensinogen T174M and M235T and the AT1-receptor A1166C polymorphisms were related to the change in LVH during antihypertensive treatment with an AT1-receptor antagonist; of these angiotensinogen T174M was the most powerful. 11910301

2002

dbSNP: rs1267969615
rs1267969615
ACE
0.050 GeneticVariation BEFREE These results suggest an association of combined angiotensin I-converting enzyme gene I/D polymorphism genotypes, and angiotensinogen gene M235T polymorphism genotypes with left ventricular hypertrophy due to long-term athletic training. 11737220

2001

dbSNP: rs1267969615
rs1267969615
ACE
0.050 GeneticVariation BEFREE There are controversies concerning the association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism with left ventricular hypertrophy (LVH), and the unclear association between angiotensinogen (ATG) M235T polymorphism and LVH. 10646957

2000

dbSNP: rs1267969615
rs1267969615
ACE
0.050 GeneticVariation BEFREE Angiotensinogen gene M235T polymorphism is associated with the variability in left ventricular hypertrophy induced by endurance training, with athletes homozygous for the T allele having the largest hearts. 10440164

1999

dbSNP: rs397516005
rs397516005
0.040 GeneticVariation BEFREE We studied 140 carriers (G+) of the TPM1-Asp175Asn or MYBPC3-Gln1061X pathogenic variants for HCM: The G+/LVH+ group (n = 98) consisted of mutation carriers with LVH and the G+/LVH- group (n = 42) without LVH. 30497761

2019

dbSNP: rs397516005
rs397516005
0.040 GeneticVariation BEFREE Septal convexity was significantly increased in subjects with the MYBPC3-Q1061X mutation and LVH (n = 32) compared to controls (11.4 ± 4.3 vs 2.7 ± 3.2 mm, P < 0.001). 30976029

2019

dbSNP: rs397516005
rs397516005
0.040 GeneticVariation BEFREE Our objective was to measure the length of mitral valve leaflets by cardiovascular magnetic resonance (CMR) in subjects with HCM caused by a Finnish founder mutation in the myosin-binding protein C gene (MYBPC3-Q1061X), carriers of the same mutation without left ventricular hypertrophy, as well as in unselected consecutive patients with HCM, and respective controls. 27259862

2016

dbSNP: rs397516005
rs397516005
0.040 GeneticVariation BEFREE Concentrations of branched chain amino acids, triglycerides and ether phospholipids were increased in mutation carriers with hypertrophy as compared to controls and non-hypertrophic mutation carriers, and correlated with echocardiographic LVH and signs of diastolic and systolic dysfunction in subjects with the MYBPC3-Q1061X mutation. 26267065

2015