|
rs763809932
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs7574865
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our data support that SNP rs7574865 is associated with response to PEG-IFN therapy in Thai patients with CHB, regardless of baseline HBeAg status.
|
31421662 |
2019 |
|
rs7574865
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Validation with all the genetic models revealed that rs7574865 polymorphism of <i>STAT4</i> gene was closely associated with chronic HBV infection (<i>P</i><sub>A</sub><0.01) and chronic hepatitis B (CHB)-related HCC (<i>P</i><sub>A</sub><0.05).
|
31160486 |
2019 |
|
rs7574865
|
|
|
0.060 |
GeneticVariation |
BEFREE |
STAT4 rs7574865 was genotyped in 1085 subjects (830 with CHB and 255 healthy controls).
|
29963713 |
2018 |
|
rs7574865
|
|
|
0.060 |
GeneticVariation |
BEFREE |
STAT4 rs7574865 is a reliable predictor of response to IFNα therapy for HBeAg-positive CHB patients and may be used for optimizing the treatment of CHB.
|
26704347 |
2016 |
|
rs7574865
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Recent studies demonstrated that single nucleotide polymorphisms (SNPs) rs2293152 in signal transducer and activator of transcription 3 (STAT3) and rs7574865 in signal transducer and activator of transcription 4 (STAT4) are associated with chronic hepatitis B (CHB)-related HCC in the Chinese population.
|
26745093 |
2015 |
|
rs7574865
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The STAT4 variant (rs7574865) was marginally associated with HCC susceptibility in CHB carriers in allelic and recessive genetic models (OR=0.84, 95%CI=0.7-0.99, P=0.048 and OR=0.7, 95%CI=0.5-0.99, P=0.047).
|
23748017 |
2013 |
|
rs738409
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Although the PNPLA3 rs738409 G allele has been associated with the risk of steatosis in CHB patients, no association between this polymorphism and the risk of cirrhosis was seen.
|
29218813 |
2018 |
|
rs738409
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The aim of the present study was to evaluate the influence of the PNPLA3 I148M polymorphisms on the clinical, histological, viral, and host parameters in Italian patients with chronic hepatitis B (CHB).
|
25986529 |
2015 |
|
rs738409
|
|
|
0.050 |
GeneticVariation |
BEFREE |
As compared to those with C/C and C/G at rs738409, C/C and C/T at rs3747206, G/G and G/A at rs4823173, and A/A and A/G at rs2072906, patients in the CHB + NAFLD group with G/G at rs738409</span>, T/T at rs3747206, A/A at rs4823173, and G/G at rs2072906 showed significantly lower serum levels of HBV DNA (P < 0.01-0.05).
|
26229402 |
2015 |
|
rs738409
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We aimed to assess the association between the patatin-like phospholipase domain-containing-3 (PNPLA3) I148M polymorphism, liver histology and long-term outcome in chronic hepatitis B (CHB) patients.
|
25284145 |
2015 |
|
rs3077
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The genotype distribution in HBV carriers relative to those who resolved HBV showed that rs3077 and rs9277378 were significantly associated with protective effects against CHB in minor dominant model (OR = 0.45, p<0.001 and OR = 0.47, p<0.001).
|
24465836 |
2014 |
|
rs3077
|
|
|
0.050 |
GeneticVariation |
BEFREE |
There was no significant association between HLA-DP polymorphism (rs3077) and IFN-γ receptor-2 gene polymorphism (rs2284553) with viral activity in HBeAg-negative CHB patients.
|
23980639 |
2014 |
|
rs738409
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate whether PNPLA3 I148M influences steatosis susceptibility in a large series of patients with CHB.
|
23564580 |
2013 |
|
rs3077
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, no significant association was seen for rs3077 with progressive CHB infection versus inactive HBsAg carrier status (OR = 2.7, 95% CI: 0.6-11.1; p = 0.31).
|
22448225 |
2012 |
|
rs3077
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We also found that the HLA-DPA1 and HLA-DPB1 genes were significantly associated with protective effects against chronic hepatitis B (CHB) in Japanese, Korean and other Asian populations, including Chinese and Thai individuals (P(meta) = 4.40×10⁻¹⁹ for rs3077 and P(meta) = 1.28×10⁻¹⁵ for rs9277542).
|
22737229 |
2012 |
|
rs3077
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Association of CHB with SNPs rs2856718 and rs7453920 remains significant even after stratification with rs3077 and rs9277535, indicating independent effect of HLA-DQ variants on CHB susceptibility (P-value of 1.52 × 10(-21)- 2.38 × 10(-30)).
|
21750111 |
2011 |
|
rs12979860
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We concluded that two polymorphisms (rs12979860 and rs8099917) of IFNL3 may play a crucial role in the IFN-based treatment of CHB, especially in HBeAg positive group.
|
31201901 |
2019 |
|
rs8099917
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We concluded that two polymorphisms (rs12979860 and rs8099917) of IFNL3 may play a crucial role in the IFN-based treatment of CHB, especially in HBeAg positive group.
|
31201901 |
2019 |
|
rs2296651
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Intriguingly, ten individuals were identified as S267F homozygotes in population studies of chronic hepatitis B (CHB) patients.
|
30032030 |
2018 |
|
rs9277535
|
|
|
0.040 |
GeneticVariation |
BEFREE |
rs1883832 serves as a valuable predictive factor for CHB patients with HBeAg seroconversion. rs9277535 at HLA-DP might also be a valuable predictive factor for CHB patients with HBeAg-negative, however, further verifications are recommended due to study limitations.
|
29451182 |
2018 |
|
rs2296651
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The frequency of the S267F variant in CHB, cirrhosis and hepatocellular carcinoma (HCC) patients was 3.3%, 0.9%, and 3.5%, respectively.
|
29247233 |
2017 |
|
rs2296651
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The frequency of rs2296651-GA was inversely correlated with CHB, LC or HCC patients [adjusted OR(95%CI)=0.16(0.11-0.23), <i>p</i><0.001; 0.34(0.21-0.55), <i>p</i>=0.001; or 0.46(0.25-0.83), <i>p</i>=0.008], respectively, compared with HCs.
|
29285260 |
2017 |
|
rs2296651
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Together with serum HBV DNA levels, S267F may help to identify patients with CHB with very low risk of HCC.
|
26642861 |
2016 |
|
rs12979860
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In this study, we aimed to evaluate the effect of two single nucleotide polymorphisms (SNPs) of interleukin 28B (IL28B) (rs12979860C/T and rs8099917G/T) on chronic hepatitis B virus (CHB) infection in Thai population.
|
25664396 |
2015 |