|
rs671
|
|
|
0.080 |
GeneticVariation |
BEFREE |
However, the results remain inconclusive.We conducted a comprehensive meta-analysis including 63 articles with 66 studies containing 25,682 cases and 47,455 controls retrieved by searching PubMed and Embase electronic databases up to March 5, 2018.Pooled results indicated that ALDH2 gene rs671 polymorphism was significantly associated with the overall cancer risk in Asians (homozygous model: odds ratio [OR] = 0.85, 95% confidence interval [CI] = 0.72-0.99, P = .042; heterozygous model: OR = 1.32, 95% CI = 1.14-1.52, P < .001; recessive model: OR = 0.73, 95% CI = 0.60-0.88, P = .001; dominant model: OR = 1.32, 95% CI = 1.16-1.51, P < .001; and allele comparison model: OR = 1.11, 95% CI = 1.03-1.19, P = .004), especially in esophageal cancer and among the Chinese and the Japanese.Our results suggest that ALDH2 rs671 polymorphism is associated with the overall cancer risk in Asians.
|
30921184 |
2019 |
|
rs671
|
|
|
0.080 |
GeneticVariation |
BEFREE |
This study aims to investigate the relationship between ALDH2 rs671 and c12orf30 rs4767364 polymorphisms in the chromosome 12q24 gene, and risk and prognosis of individuals developing esophageal cancer (ESCC) in Xinjiang Kazak and Han populations.
|
28464297 |
2018 |
|
rs671
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Among male daily consumers, the HRs (95% CIs) for EC associated with 15g/d of alcohol were 1.28 (1.15, 1.44) for "soon" response [vs. other responses: 1.12 (1.09, 1.15); p<sub>interaction</sub> = 0.047; n = 36,401, 425 EC cases] and 1.41 (1.08, 1.82) for rs671 GA [vs. GG: 1.16 (1.06, 1.27); p<sub>interaction</sub> = 0.493; n = 6,607, 80 EC cases].
|
29707772 |
2018 |
|
rs671
|
|
|
0.080 |
GeneticVariation |
BEFREE |
This meta-analysis concluded that there was a strong association between ALDH2 Glu487Lys</span> polymorphism and the risk of esophageal cancer.
|
28422823 |
2017 |
|
rs671
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our results indicated that the ALDH2 Glu504Lys polymorphism is a susceptible loci associated with overall cancers, especially esophageal cancer and among Japanese population.
|
25680115 |
2015 |
|
rs671
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In conclusion, our findings indicated that ADH1B (rs1229984) was associated with EC independent of alcohol drinking and tobacco smoking status and alcohol drinking interacted with ALDH2 (rs671) on EC susceptibility in this high-risk Chinese population.
|
22930414 |
2013 |
|
rs671
|
|
|
0.080 |
GeneticVariation |
BEFREE |
To assess the actual influence of ADH2 Arg47His, ALDH2 Glu487Lys and CYP2E1 variant c2 allele polymorphisms on esophageal cancer risk with conjunction with alcoholic consumption, the present 1:3 matched case-control study was conducted.
|
16235983 |
2005 |
|
rs671
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Its encoding gene ALDH2 has a functional polymorphism: ALDH2 Glu487LYS: An association between this polymorphism and esophageal cancer among alcoholics has been reported.
|
11375898 |
2001 |