Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs113488022
rs113488022
0.050 GeneticVariation BEFREE These findings suggest that the BRAF(V600E) mutation can be detected using a PNA clamp real-time PCR in the blood of PTC patients with lung metastasis. 25837167

2015

dbSNP: rs121913377
rs121913377
0.050 GeneticVariation BEFREE These findings suggest that the BRAF(V600E) mutation can be detected using a PNA clamp real-time PCR in the blood of PTC patients with lung metastasis. 25837167

2015

dbSNP: rs113488022
rs113488022
0.050 GeneticVariation BEFREE NK cell frequencies were significantly enhanced by PLX4720 specifically in the lungs of mice with BRAF(V600E) lung metastases. 25351955

2014

dbSNP: rs121913377
rs121913377
0.050 GeneticVariation BEFREE NK cell frequencies were significantly enhanced by PLX4720 specifically in the lungs of mice with BRAF(V600E) lung metastases. 25351955

2014

dbSNP: rs113488022
rs113488022
0.050 GeneticVariation BEFREE B-Raf(V600E) cells in which either B-Raf(V600E) or TSP-1 were knocked down were implanted orthotopically into the thyroids of immunocompromised mice, resulting in significant reduction in tumor size and fewer pulmonary metastases from the primary carcinoma as compared with the control cells. 20498063

2010

dbSNP: rs121913377
rs121913377
0.050 GeneticVariation BEFREE B-Raf(V600E) cells in which either B-Raf(V600E) or TSP-1 were knocked down were implanted orthotopically into the thyroids of immunocompromised mice, resulting in significant reduction in tumor size and fewer pulmonary metastases from the primary carcinoma as compared with the control cells. 20498063

2010

dbSNP: rs113488022
rs113488022
0.050 GeneticVariation BEFREE Results indicated that knockdown of mutant (V600E)B-Raf inhibited melanoma cell extravasation in vitro and subsequent lung metastasis development in vivo. 17575149

2007

dbSNP: rs121913377
rs121913377
0.050 GeneticVariation BEFREE Results indicated that knockdown of mutant (V600E)B-Raf inhibited melanoma cell extravasation in vitro and subsequent lung metastasis development in vivo. 17575149

2007

dbSNP: rs113488022
rs113488022
0.050 GeneticVariation BEFREE Here, we investigated the role played by (V600E)B-Raf in melanoma metastasis and showed that targeting this signaling cascade significantly reduces lung metastases. 16912199

2006

dbSNP: rs121913377
rs121913377
0.050 GeneticVariation BEFREE Here, we investigated the role played by (V600E)B-Raf in melanoma metastasis and showed that targeting this signaling cascade significantly reduces lung metastases. 16912199

2006

dbSNP: rs1057519847
rs1057519847
0.020 GeneticVariation BEFREE Oncogenic L858R mutation of human epidermal growth factor receptor (EGFR) confers constitutive activation to the kinase and is frequently observed in the pathological process of metastatic lung cancer. 27643705

2016

dbSNP: rs1057519848
rs1057519848
0.020 GeneticVariation BEFREE Oncogenic L858R mutation of human epidermal growth factor receptor (EGFR) confers constitutive activation to the kinase and is frequently observed in the pathological process of metastatic lung cancer. 27643705

2016

dbSNP: rs121434568
rs121434568
0.020 GeneticVariation BEFREE Oncogenic L858R mutation of human epidermal growth factor receptor (EGFR) confers constitutive activation to the kinase and is frequently observed in the pathological process of metastatic lung cancer. 27643705

2016

dbSNP: rs1057519847
rs1057519847
0.020 GeneticVariation BEFREE There was a significant difference in newly development of lung metastasis between patients with exon 19 deletion and those with L858R mutation (41.4% vs. 6.3%, p=0.02).PPS was 8.9 months (95% CI, 7.4-10.4). 24309368

2014

dbSNP: rs1057519848
rs1057519848
0.020 GeneticVariation BEFREE There was a significant difference in newly development of lung metastasis between patients with exon 19 deletion and those with L858R mutation (41.4% vs. 6.3%, p=0.02).PPS was 8.9 months (95% CI, 7.4-10.4). 24309368

2014

dbSNP: rs121434568
rs121434568
0.020 GeneticVariation BEFREE There was a significant difference in newly development of lung metastasis between patients with exon 19 deletion and those with L858R mutation (41.4% vs. 6.3%, p=0.02).PPS was 8.9 months (95% CI, 7.4-10.4). 24309368

2014

dbSNP: rs121434569
rs121434569
0.010 GeneticVariation BEFREE T790M detection was associated with higher number of new progressing sites (P = .04), liver progression (P = .002), and a lower frequency of lung metastases (P = .027). 31601525

2020

dbSNP: rs3217992
rs3217992
0.010 GeneticVariation BEFREE In addition, the GA and AA genotypes of rs3217992 in CDKN2A might indicate higher stage and increased risk of lung metastasis of osteosarcoma, resulting in worse prognosis. 30774116

2019

dbSNP: rs201701502
rs201701502
0.010 GeneticVariation BEFREE Although Forced expression of DDR2 and its mutant (T681I) led to induce SQCC cell invasion in vitro, only wild type DDR2 enhanced lung metastasis in an animal model. 28676216

2017

dbSNP: rs121909222
rs121909222
0.010 GeneticVariation BEFREE Accordingly, following tail vein injection, both Pten(∆):p53(R270H) spindle and PDA tumor cells induced lung metastases and morbidity significantly faster than Pten(∆):p53(∆) double-deletion cells, and this was associated with the ability of Pten(∆):p53(R270H) tumor cells to upregulate E-cadherin expression in lung metastases. 26781438

2016

dbSNP: rs1989839
rs1989839
0.010 GeneticVariation BEFREE Furthermore, rs1989839C/T is also associated with the Enneking stage of osteosarcoma and risk of lung metastasis. 27880743

2016

dbSNP: rs754533102
rs754533102
0.010 GeneticVariation BEFREE By introduction of gene Msurvivin T34A in combination with chemotherapies in the treatment of lung metastasis tumor, it could greatly reduce systemic toxicity as well as improved the anti-tumor efficiency. 24582554

2014

dbSNP: rs1430452530
rs1430452530
0.010 GeneticVariation BEFREE We show that loss of HIF-1α or PLOD2 expression disrupts collagen modification, cell migration, and pulmonary metastasis (but not primary tumor growth) in allograft and autochthonous LSL-Kras(G12D/+); Trp53(fl/fl) murine sarcoma models. 23906982

2013

dbSNP: rs762846821
rs762846821
0.010 GeneticVariation BEFREE We show that loss of HIF-1α or PLOD2 expression disrupts collagen modification, cell migration, and pulmonary metastasis (but not primary tumor growth) in allograft and autochthonous LSL-Kras(G12D/+); Trp53(fl/fl) murine sarcoma models. 23906982

2013

dbSNP: rs762959475
rs762959475
0.010 GeneticVariation BEFREE We show that loss of HIF-1α or PLOD2 expression disrupts collagen modification, cell migration, and pulmonary metastasis (but not primary tumor growth) in allograft and autochthonous LSL-Kras(G12D/+); Trp53(fl/fl) murine sarcoma models. 23906982

2013