Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
MTHFR
0.050 GeneticVariation BEFREE CONCLUSION: Although MTHFR C677T and A1298C are significantly associated with some types of congenital defects and adverse pregnancy outcomes, the impact of these polymorphisms is moderate. 30474229

2019
dbSNP: rs1217691063
rs1217691063
MTHFR
0.050 GeneticVariation BEFREE The MTHFR C677T polymorphism was significantly associated with 42 clinical disorders (p < 0.05), mostly relating to the diseases of circulatory system, birth defects and cancers. 27888505

2017
dbSNP: rs1217691063
rs1217691063
MTHFR
0.050 GeneticVariation BEFREE C677T polymorphism of MTHFR gene was reported as risk factor for congenital defects, metabolic and neuropsychiatric disorders. 27025471

2016
dbSNP: rs1217691063
rs1217691063
MTHFR
0.050 GeneticVariation BEFREE The MTHFR 677C > T polymorphism in conjunction with reduced folate- and/or cobalamin status may increase the risk of complex birth defects. 18435414

2008
dbSNP: rs1217691063
rs1217691063
MTHFR
0.050 GeneticVariation BEFREE We studied whether two polymorphisms in the MTHFR gene (677C-->T and 1298A-->C) are associated with pregnancy complications, adverse outcomes, and birth defects. 15210385

2004
dbSNP: rs397507444
rs397507444
MTHFR
0.020 GeneticVariation BEFREE CONCLUSION: Although MTHFR C677T and A1298C are significantly associated with some types of congenital defects and adverse pregnancy outcomes, the impact of these polymorphisms is moderate. 30474229

2019
dbSNP: rs397507444
rs397507444
MTHFR
0.020 GeneticVariation BEFREE We studied whether two polymorphisms in the MTHFR gene (677C-->T and 1298A-->C) are associated with pregnancy complications, adverse outcomes, and birth defects. 15210385

2004
dbSNP: rs4988235
rs4988235
MCM6
0.010 GeneticVariation BEFREE Maternal Lactase Polymorphism (rs4988235) Is Associated with Neural Tube Defects in Offspring in the National Birth Defects Prevention Study. 30689919

2019
dbSNP: rs2236225
rs2236225
MTHFD1
0.010 GeneticVariation BEFREE In people, a single nucleotide polymorphism of this gene (1958G>A; rs2236225) is associated with increased risk for bipolar disorder and schizophrenia, neural tube and other birth defects. 28559181

2017
dbSNP: rs368705607
rs368705607
MIXL1
0.010 GeneticVariation BEFREE C677T polymorphism of MTHFR gene was reported as risk factor for congenital defects, metabolic and neuropsychiatric disorders. 27025471

2016
dbSNP: rs1799983
rs1799983
NOS3
0.010 GeneticVariation BEFREE In humans, a single nucleotide polymorphism in the gene coding for eNOS (894G>T) is associated with birth defects. 18844489

2008