Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799939
rs1799939
RET
0.070 GeneticVariation BEFREE (3) The single-nucleotide polymorphisms (SNP) G691S in exon 11 (rs1799939), S904S in exon 15 (rs1800863), and rs2075912 and rs2565200 in the 3'-untranslated region of the RET proto-oncogene are in complete linkage disequilibrium (D' = 1, r2 = 1); no correlation of these SNP and MTC was observed in this pedigree. 27798940

2017

dbSNP: rs1799939
rs1799939
RET
0.070 GeneticVariation BEFREE The modifier role of RET-G691S polymorphism in hereditary medullary thyroid carcinoma: functional characterization and expression/penetrance studies. 25887804

2015

dbSNP: rs1799939
rs1799939
RET
0.070 GeneticVariation BEFREE In silico analyses on G691S confirmed a change of the phosphorylation pattern that might account for the enhanced signaling transduction previously reported for G691S in several cancers, thus also explaining its overrepresentation in MTCs. 23180660

2013

dbSNP: rs1799939
rs1799939
RET
0.070 GeneticVariation BEFREE Here, we investigated the influence of multiple RET variants (G691S, L769L, S836S, and S904S) on the risk of MTC and tumor behavior. 22345297

2012

dbSNP: rs1799939
rs1799939
RET
0.070 GeneticVariation BEFREE Clinical relevance of RET variants G691S, L769L, S836S and S904S to sporadic medullary thyroid cancer. 22111543

2012

dbSNP: rs1799939
rs1799939
RET
0.070 GeneticVariation BEFREE SNPs in exon 11 (G691S) and exon 15 (S904S) appear to influence the development of MTC. 21134561

2010

dbSNP: rs1799939
rs1799939
RET
0.070 GeneticVariation BEFREE The prevalence of the RET polymorphism G691S of exon 11 is higher in patients with medullary thyroid carcinoma (MTC) as compared to the general population. 19411807

2009