rs965513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The functional variants rs965513 and rs1867277 independently contribute to genetic predisposition to PTC, while a contributing role of the FOXE1 poly-Ala polymorphism could not be confirmed.
|
27824288 |
2017 |
rs965513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There were significant associations of all SNPs with PTC (rs965513 odds ratio [OR] = 1.72, p = 8 × 10-7; rs1867277 OR = 1.59, p = 1 × 10-6; rs1443434 OR = 1.53, p = 1 × 10-5; rs944289 OR = 1.52, p = 4 × 10-5).
|
28660995 |
2017 |
rs965513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We propose that the interaction between the lncRNA, its binding protein MYH9, and the coding gene FOXE1 underlies the predisposition to PTC triggered by rs965513.
|
28049826 |
2017 |
rs965513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association between rs965513 and PTC in different ethnicities and countries, we conducted a meta-analysis using relatively large-scale samples from 23 studies (N = 163,136; 20,736 cases and 142,400 controls) by searching the PubMed and Google Scholar databases.
|
27191655 |
2016 |
rs965513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped rs965513 from PTC patients and measured gene expression levels by real-time RT-PCR in unaffected thyroid tissue and matched tumor.
|
25303483 |
2015 |
rs965513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Four GWAS-identified SNPs of papillary thyroid cancer (PTC), rs965513, rs944289, rs966423 and rs2439302, were genotyped in a case-control study of 838 patients with PTC and 501 patients with benign thyroid tumor (BTT) from the Chinese Han population.
|
25746573 |
2015 |
rs965513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The [A] allele of SNP rs965513 in 9q22 has been consistently shown to be highly associated with increased papillary thyroid cancer (PTC</span>) risk with an odds ratio of ∼1.8 as determined by genome-wide association studies, yet the molecular mechanisms remain poorly understood.
|
25918370 |
2015 |
rs965513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Similarly, the rs965513 on the TTF2 can also elevate the risk of PTC significantly (GA vs GG, OR = 1.67, 95% CI = 1.07-2.59; AA+GA vs AA, OR = 1.37, 95% CI = 1.09-1.82; A vs G, OR = 1.29, 95% CI = 1.05-1.59).
|
26356687 |
2015 |
rs965513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results showed significant associations of rs965513/rs944289 with PTC risk existed in overall population (for rs965513, A vs. G: OR 1.71 (1.56-1.86); for rs944289, T vs. C: OR 1.29 (1.23-1.37)).
|
24723258 |
2014 |
rs965513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Four candidate loci, rs965513 (9q22.33), rs944289 (14q13.3), rs966423 (2q35) and rs2439302 (8p12), identified by GWAS for PTC risk were confirmed in a Chinese population.
|
23847140 |
2013 |
rs965513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A genome-wide association study of papillary thyroid carcinoma (PTC) pinpointed two independent SNPs (rs944289 and rs965513) located in regions containing no annotated genes (14q13.3 and 9q22.33, respectively).
|
22586128 |
2012 |
rs965513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association of both rs965513 (p=1.27×10(-4), OR=1.69, 95% CI 1.29 to 2.21) and rs944289 (p=0.0121, OR=1.21, 95% CI 1.04 to 1.39) with the risk of sporadic PTC was confirmed.
|
21730105 |
2011 |