Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs429358
rs429358
0.020 GeneticVariation BEFREE After taking into account confounding factors and correcting for multiple comparisons only APOE rs429358 and rs7412 variants remained significantly associated with risk of dyslipidemia. 26043189

2015

dbSNP: rs429358
rs429358
0.020 GeneticVariation BEFREE ApoE4 which differs from apoE3 by the single amino acid substitution Cys112Arg is also associated with dyslipidemia although binding of this isoform to the LDLR is unaffected. 25328986

2014

dbSNP: rs7412
rs7412
0.010 GeneticVariation BEFREE After taking into account confounding factors and correcting for multiple comparisons only APOE rs429358 and rs7412 variants remained significantly associated with risk of dyslipidemia. 26043189

2015

dbSNP: rs573658040
rs573658040
0.010 GeneticVariation BEFREE Prevalence of the apolipoprotein E Arg145Cys dyslipidemia at-risk polymorphism in African-derived populations. 24239320

2014

dbSNP: rs769455
rs769455
0.010 GeneticVariation BEFREE Prevalence of the apolipoprotein E Arg145Cys dyslipidemia at-risk polymorphism in African-derived populations. 24239320

2014

dbSNP: rs387906567
rs387906567
0.010 GeneticVariation BEFREE The prevention of apoE4[R142C]-induced dyslipidemia by deletion of the 203-299 residues suggests that, in the full-length protein, the R142C substitution may have altered the conformation of apoE bound to VLDL/IDL/LDL in ways that prevent triglyceride hydrolysis, cholesterol esterification, and receptor-mediated clearance in vivo. 20861163

2011

dbSNP: rs11542035
rs11542035
0.010 GeneticVariation BEFREE Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3' (Arg136-->His): association with mild dyslipidemia and double pre-beta very low density lipoproteins. 7706948

1995