Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.020 | GeneticVariation | BEFREE | After taking into account confounding factors and correcting for multiple comparisons only APOE rs429358 and rs7412 variants remained significantly associated with risk of dyslipidemia. | 26043189 | 2015 |
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0.020 | GeneticVariation | BEFREE | ApoE4 which differs from apoE3 by the single amino acid substitution Cys112Arg is also associated with dyslipidemia although binding of this isoform to the LDLR is unaffected. | 25328986 | 2014 |
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0.010 | GeneticVariation | BEFREE | After taking into account confounding factors and correcting for multiple comparisons only APOE rs429358 and rs7412 variants remained significantly associated with risk of dyslipidemia. | 26043189 | 2015 |
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0.010 | GeneticVariation | BEFREE | Prevalence of the apolipoprotein E Arg145Cys dyslipidemia at-risk polymorphism in African-derived populations. | 24239320 | 2014 |
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0.010 | GeneticVariation | BEFREE | Prevalence of the apolipoprotein E Arg145Cys dyslipidemia at-risk polymorphism in African-derived populations. | 24239320 | 2014 |
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0.010 | GeneticVariation | BEFREE | The prevention of apoE4[R142C]-induced dyslipidemia by deletion of the 203-299 residues suggests that, in the full-length protein, the R142C substitution may have altered the conformation of apoE bound to VLDL/IDL/LDL in ways that prevent triglyceride hydrolysis, cholesterol esterification, and receptor-mediated clearance in vivo. | 20861163 | 2011 |
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0.010 | GeneticVariation | BEFREE | Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3' (Arg136-->His): association with mild dyslipidemia and double pre-beta very low density lipoproteins. | 7706948 | 1995 |