Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.030 | GeneticVariation | BEFREE | Identification of a novel HER3 activating mutation homologous to EGFR-L858R in lung cancer. | 26689995 | 2016 |
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0.030 | GeneticVariation | BEFREE | In preclinical studies, afatinib not only inhibited the growth of models with common activating EGFR mutations, but was also active in lung cancer models harboring wild-type EGFR or the EGFR L858R/T790M double mutant. | 23664448 | 2013 |
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0.030 | GeneticVariation | BEFREE | EGFR mutations (CTG-->CGG; L858R) were found from 14 of 95 lung cancer patients. | 16003726 | 2006 |
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0.010 | GeneticVariation | BEFREE | Consistent with this, a G660D germline mutant lung cancer patient showed remarkable clinical response to HER2 blockade. | 30449325 | 2018 |
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0.010 | GeneticVariation | BEFREE | Atomistic insights into the lung cancer-associated L755P mutation in HER2 resistance to lapatinib: a molecular dynamics study. | 25620423 | 2015 |
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0.010 | GeneticVariation | BEFREE | Atomistic insights into the lung cancer-associated L755P mutation in HER2 resistance to lapatinib: a molecular dynamics study. | 25620423 | 2015 |
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0.010 | GeneticVariation | BEFREE | The AKT1 (E17K) mutation has been reported in some tumour types (breast, colorectal, ovarian and lung cancers), and it is of interest which tumour types other than those possess the E17K mutation. | 19491896 | 2009 |
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0.010 | GeneticVariation | BEFREE | In this study, we investigated whether the four polymorphisms (-3444C>T, -1985 G>T, I655A A>G and P1170A C>G) of the HER-2 gene are associated with the risk of lung cancer in Korean populations. | 19055823 | 2008 |