Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11540654
rs11540654
0.100 GeneticVariation BEFREE We conclude that not Pro47Ser SNP but Arg72Pro SNP is involved in susceptibility to developing lung cancer, at least in Bangladeshi population. 25034526

2015

dbSNP: rs11540654
rs11540654
0.100 GeneticVariation BEFREE Present report evaluated the association of polymorphism in exon 4 Arg72Pro (G>C) of the p53 gene with lung cancer susceptibility using 175 cancer cases and 202 controls from the North Indian population. 23317414

2013

dbSNP: rs11540654
rs11540654
0.100 GeneticVariation BEFREE P53 codon 72 Arg/Pro polymorphism and lung cancer risk in Asians: an updated meta-analysis. 23812725

2013

dbSNP: rs11540654
rs11540654
0.100 GeneticVariation BEFREE TP53 Arg72Pro polymorphism and lung cancer risk: a meta-analysis. 19623649

2009

dbSNP: rs11540654
rs11540654
0.100 GeneticVariation BEFREE The TP53 Arg72Pro polymorphism and lung cancer risk in a population of Northern Spain. 18336951

2009

dbSNP: rs11540654
rs11540654
0.100 GeneticVariation BEFREE Four of the variants were found to be weakly associated with lung cancer risk with borderline significance: these were XRCC3 T241M [heterozygote odds ratio (OR), 0.89; 95% confidence interval (95% CI), 0.79-0.99 and homozygote OR, 0.84; 95% CI, 0.71-1.00] based on 3,467 cases and 5,021 controls from 8 studies, XPD K751Q (heterozygote OR, 0.99; 95% CI, 0.89-1.10 and homozygote OR, 1.19; 95% CI, 1.02-1.39) based on 6,463 cases and 6,603 controls from 9 studies, and TP53 R72P (heterozygote OR, 1.14; 95% CI, 1.00-1.29 and homozygote OR, 1.20; 95% CI, 1.02-1.42) based on 3,610 cases and 5,293 controls from 6 studies. 18990748

2009

dbSNP: rs11540654
rs11540654
0.100 GeneticVariation BEFREE Therefore, we hypothesized that the genetic variants in these three genes influence the predisposition of lung cancer (i.e., CCND1 G870A, CDKN2A Ala(148)Thr, TP53 Arg(72)Pro, and 16-bp repeat in intron 3) and that the effect of X-ray on lung cancer risk can be modified by the presence of these genetic variations. 16912209

2007

dbSNP: rs11540654
rs11540654
0.100 GeneticVariation BEFREE Lack of evidence that p53 Arg72Pro influences lung cancer prognosis: an analysis of survival in 619 female patients. 17400332

2007

dbSNP: rs11540654
rs11540654
0.100 GeneticVariation BEFREE We therefore investigated the combined effects of polymorphisms in TP53 (Arg72Pro) and p21/CDKN1A (Ser31Arg) and smoking on lung cancer risk. 17059853

2007

dbSNP: rs11540654
rs11540654
0.100 GeneticVariation BEFREE We investigated the association between genetic variation in the promoter region of MDM2 (c.-5+309G>T, rs2279744:g.G>T) and the coding region of TP53 (c.215G>C, rs1042522:g.G>C, designated Arg72Pro) and the risk of developing lung cancer. 16287156

2006

dbSNP: rs11540654
rs11540654
0.100 GeneticVariation BEFREE The amino acid replacement of arginine by proline at codon 72 of TP53 appears not to be important in determining lung cancer risk in this population. 11097227

2001

dbSNP: rs1042522
rs1042522
0.030 GeneticVariation BEFREE The variant genotype of TP53 SNP rs1042522 significantly increased lung cancer risk in the total population (OR: 1.57, 95% CI: 1.11-2.21), but there was no evidence of heterogeneity among individuals with different lifestyle factors. 24369748

2014

dbSNP: rs1042522
rs1042522
0.030 GeneticVariation BEFREE African Americans with Pro-T-A-G-G haplotypes of the combined TP53 polymorphisms TP53_01 (rs1042522), TP53_65 (rs9895829), TP53_66 (rs2909430), TP53_16 (rs1625895), and TP53_11 (rs12951053) had both an increased risk for lung cancer (odds ratio, 2.32; 95% confidence interval, 1.18-4.57) and a worsened lung cancer prognosis (hazards ratio, 2.38; 95% confidence interval, 1.38-4.10) compared with those with Arg-T-A-G-T haplotypes. 17301252

2007

dbSNP: rs1042522
rs1042522
0.030 GeneticVariation BEFREE We investigated the association between genetic variation in the promoter region of MDM2 (c.-5+309G>T, rs2279744:g.G>T) and the coding region of TP53 (c.215G>C, rs1042522:g.G>C, designated Arg72Pro) and the risk of developing lung cancer. 16287156

2006

dbSNP: rs759728549
rs759728549
0.020 GeneticVariation BEFREE In this study, we have investigated the delivery and transfection of wild-type (wt-) p53 and microRNA-125b (miR-125b) expressing plasmid DNA, in SK-LU-1 human lung adenocarcinoma cells as well as in Kras(G12D)/p53(fl/fl) (KP) genetically engineered mouse model of lung cancer. 26686386

2016

dbSNP: rs28934578
rs28934578
0.020 GeneticVariation BEFREE Ecotopic expression of wild-type p53, but not mutant p53 (R175H) suppressed both endogenous and exogenous 14-3-3γ in colon and lung cancer cell lines. 25384678

2015

dbSNP: rs573154688
rs573154688
0.020 GeneticVariation BEFREE Ecotopic expression of wild-type p53, but not mutant p53 (R175H) suppressed both endogenous and exogenous 14-3-3γ in colon and lung cancer cell lines. 25384678

2015

dbSNP: rs759728549
rs759728549
0.020 GeneticVariation BEFREE Further, in order to investigate whether IL-6 deletion contributes to suppression of lung cancer metastasis, we generated Kras(G12D); p53(flox/flox); IL-6(-/-) mice, which developed lung cancer with a trend for reduced metastases and longer survival than Kras(G12D); p53(flox/flox) mice. 24260500

2014

dbSNP: rs28934578
rs28934578
0.020 GeneticVariation BEFREE Twist1 levels were also elevated in metastatic prostate cancer-derived cell line DU145, in immortalized lung fibroblasts and in a subset of lung cancer samples, all in a mutant p53-dependent manner. p53(R175H) mutant bearing immortalized epithelial cells showed typical features of EMT, such as higher expression of mesenchymal markers, lower expression of epithelial markers and enhanced invasive properties in vitro. 20689556

2011

dbSNP: rs573154688
rs573154688
0.020 GeneticVariation BEFREE Twist1 levels were also elevated in metastatic prostate cancer-derived cell line DU145, in immortalized lung fibroblasts and in a subset of lung cancer samples, all in a mutant p53-dependent manner. p53(R175H) mutant bearing immortalized epithelial cells showed typical features of EMT, such as higher expression of mesenchymal markers, lower expression of epithelial markers and enhanced invasive properties in vitro. 20689556

2011

dbSNP: rs760043106
rs760043106
0.020 GeneticVariation BEFREE For instance, a greater absolute risk reduction of lung and upper aerodigestive cancers in smokers than in non-smokers carrying the I157T CHEK2 variant has been observed, as has an interaction between TP53 intron 3 16-bp repeats and multiple X-ray exposures on lung cancer risk. 19442246

2009

dbSNP: rs760043106
rs760043106
0.020 GeneticVariation BEFREE In contrast, a previous report suggests that individuals with the I157T missense variant of the CHEK2 gene might be at decreased risk of lung cancer and upper aero-digestive cancers. 18281249

2008

dbSNP: rs1800371
rs1800371
0.010 GeneticVariation BEFREE We conclude that not Pro47Ser SNP but Arg72Pro SNP is involved in susceptibility to developing lung cancer, at least in Bangladeshi population. 25034526

2015

dbSNP: rs587782650
rs587782650
0.010 GeneticVariation BEFREE However, the cell growth inhibitory effect of thiacremonone was not observed in the lung cancer cells transfected with mutant PRDX6 (C47S) and in the presence of dithiothreitol and glutathione. 24618722

2015

dbSNP: rs730881997
rs730881997
0.010 GeneticVariation BEFREE However, the cell growth inhibitory effect of thiacremonone was not observed in the lung cancer cells transfected with mutant PRDX6 (C47S) and in the presence of dithiothreitol and glutathione. 24618722

2015