|
rs1051730
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In addition, the A alleles in CHRNA3 rs1051730 and CHRNA5 rs16969968 were associated with the risk for LC (OR = 1.66, P = 0.07 and OR = 1.57, P = 0.1, respectively) and for COPD (OR = 2.04, P = 0.01 and OR = 1.91, P = 0.02, respectively).
|
29993116 |
2018 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
By analyzing 1000 genomes data for East Asian, we identified only one SNP in nearby region, rs402710, in high linkage disequilibrium with rs401681, which was also associated with lung cancer.
|
29939218 |
2018 |
|
rs1051730
|
|
|
0.800 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, in males, the TERT rs2736098 and CLPTM1L rs401681 T alleles are the susceptibility factors for developing lung cancer.
|
28789383 |
2017 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We examined the clinicopathological and prognostic value of rs401681 variants in lung cancer.
|
29033187 |
2017 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs401681 polymorphism was significantly associated with a decreased risk of lung cancer, bladder cancer, and basal cell carcinoma in Asians and in hospital-based studies.
|
29254260 |
2017 |
|
rs8034191
|
|
|
0.800 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs1051730
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In summary, CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers.
|
27072204 |
2016 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
After adjusting for known risk loci, rs2736100 and rs401681, we identified a new, independent lung cancer susceptibility variant in LPCAT1: rs139852726 (OR = 0.46, P = 4.73×10(-9)), and three new adenocarcinoma risk variants in TERT: rs61748181 (OR = 0.53, P = 2.64×10(-6)), rs112290073 (OR = 1.85, P = 1.27×10(-5)), rs138895564 (OR = 2.16, P = 2.06×10(-5); among young cases, OR = 3.77, P = 8.41×10(-4)).
|
26590902 |
2016 |
|
rs8034191
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In summary, CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers.
|
27072204 |
2016 |
|
rs1051730
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We observed a significant association between lung cancer and rs1051730 in pooled population by using allele (OR = 1.30, 95% CI = 1.27-1.34, P < 0.0001), dominant (OR = 1.41, 95% CI = 1.29-1.55, P < 0.0001), recessive (OR = 1.53, 95% CI = 1.42-1.65, P < 0.0001) and additive (OR = 1.75, 95% CI = 1.61-1.90, P < 0.0001) models.
|
26508385 |
2015 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Recent studies have also linked rs2736100 with a longer telomere length and lung cancer risk.
|
26554909 |
2015 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The results of this study suggested that rs2736100 on TERT-CLPTM1L indicates a poor prognosis for lung cancer in the Chinese Han population.
|
25966219 |
2015 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We then found that GRSs used as instrumental variables to predict longer telomere length were associated with increased lung cancer risk (OR = 1.51 (95% CI = 1.34-1.69) for upper vs. lower quartile of the weighted GRS, p value = 4.54 × 10(-14) ) even after removing rs2736100 (p value = 4.81 × 10(-3) ), a SNP in the TERT locus robustly associated with lung cancer risk in prior association studies.
|
25516442 |
2015 |
|
rs8034191
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The association between rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that rs8034191 is a risk factor for lung cancer.
|
25854352 |
2015 |
|
rs1051730
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis demonstrated that the two common variations (rs8034191 and rs1051730) at 15q25 are a risk factor associated with increased LC susceptibility, but these associations vary in different ethnic populations.
|
24254305 |
2014 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This meta-analysis suggested that TERT rs2736100 polymorphism was a risk factor for LC.
|
24535778 |
2014 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, significantly elevated LC risk was associated with rs2736100, rs401681, rs402710, and rs31489 polymorphisms when all studies were pooled into the meta-analysis.
|
24615522 |
2014 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
TERT polymorphism (rs2736100) might be a genetic susceptibility factor for lung cancer in non-smoking females in China.
|
25037574 |
2014 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These data provide further evidence supporting a role for genetic susceptibility of TERT rs2736100 in the development of lung cancer.
|
24590268 |
2014 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis demonstrated that TERT rs2736100</span> polymorphism is a risk factor associated with increased lung cancer susceptibility, particularly for lung adenocarcinoma.
|
24390616 |
2014 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In the genetic model analysis, we found rs402710 and rs401681 were associated with decreased lung cancer risk.
|
25526467 |
2014 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, our study indicated that the CLPTM1L - rs401681 (G>A) polymorphism was significantly associated with decreased lung cancer risk, especially among European populations.
|
24634236 |
2014 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our findings demonstrated that rs402710 and rs401681 are risk-conferring factors for the development of lung cancer.
|
24907075 |
2014 |