|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The results of this study suggested that rs2736100 on TERT-CLPTM1L indicates a poor prognosis for lung cancer in the Chinese Han population.
|
25966219 |
2015 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We then found that GRSs used as instrumental variables to predict longer telomere length were associated with increased lung cancer risk (OR = 1.51 (95% CI = 1.34-1.69) for upper vs. lower quartile of the weighted GRS, p value = 4.54 × 10(-14) ) even after removing rs2736100 (p value = 4.81 × 10(-3) ), a SNP in the TERT locus robustly associated with lung cancer risk in prior association studies.
|
25516442 |
2015 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Recent studies have also linked rs2736100 with a longer telomere length and lung cancer risk.
|
26554909 |
2015 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, significantly elevated LC risk was associated with rs2736100, rs401681, rs402710, and rs31489 polymorphisms when all studies were pooled into the meta-analysis.
|
24615522 |
2014 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis demonstrated that TERT rs2736100</span> polymorphism is a risk factor associated with increased lung cancer susceptibility, particularly for lung adenocarcinoma.
|
24390616 |
2014 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
TERT polymorphism (rs2736100) might be a genetic susceptibility factor for lung cancer in non-smoking females in China.
|
25037574 |
2014 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This meta-analysis suggested that TERT rs2736100 polymorphism was a risk factor for LC.
|
24535778 |
2014 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These data provide further evidence supporting a role for genetic susceptibility of TERT rs2736100 in the development of lung cancer.
|
24590268 |
2014 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We identified one novel variant at the level corrected for multiple comparisons (rs2741354 in EPHX2 at 8p21.1 with p value = 7.4 × 10(-6)), and confirmed the associations between TERT (rs2736100) and the HLA region and lung cancer risk.
|
23370545 |
2013 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
After the 2nd stage validation (975 cases versus 1022 controls), the study clarified the association that rs2736100 of the TERT gene conferred the highest significant risk of lung cancer (P=4×10(-3) in the 1st stage association, P=4×10(-4) in the 2nd stage validation, and P=1×10(-5), odds ratio=1.24 in the combined population).
|
23368278 |
2013 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In addition, the rs2736100 G allele, which we previously have shown to be associated with risk of lung cancer in this cohort, was significantly associated with longer telomere length in these same study subjects (P trend = 0.030).
|
23555636 |
2013 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that rs2736100 is associated with the risk of lung cancer.
|
24283584 |
2013 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphisms (SNP) at 5p15 (rs2736100, adjusted odds ratio [aOR] 1.32, 95% confidence interval [CI] 1.03-1.67, P = 0.025; rs402710, aOR 0.82, 95% CI 0.69-0.98, P = 0.025; rs401681, aOR 0.82, 95% CI 0.69-0.98, P = 0.026) and at 15q25 (rs2036534, aOR 0.75, 95% CI 0.61-0.93, P = 0.01; rs6495309, aOR 0.81, 95% CI 0.65-1.00, P = 0.052) were significantly associated with lung cancer risk.
|
22404340 |
2012 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
For lung cancer, which was the most studied tumor type, the estimated joint population attributable risk for three polymorphisms (TERT rs2736100, intergenic rs4635969, and CLPTM1L rs402710) was 41%.
|
22523397 |
2012 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively).
|
21725308 |
2011 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
DQA1*03 and the minor allele for a polymorphism, rs2736100, in TERT, another lung cancer susceptibility locus identified in recent GWASs on Europeans and Americans, were indicated to independently contribute to ADC risk with per allele OR of 1.43 (95% CI = 1.31-1.56, P = 7.8 x 10(-16)).
|
20061363 |
2010 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The associations between the 5p15 variants and lung cancer differed by histology; odds ratios for rs2736100 were highest in adenocarcinoma and for rs402710 were highest in adenocarcinoma and squamous cell carcinomas.
|
20548021 |
2010 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A statistically significant association between lung cancer risk and 5p15.33 genotypes was found: rs2736100 (odds ratio = 0.78, 95% confidence interval: 0.63-0.97; P = 0.02), rs4975616 (odds ratio = 0.69, 95% confidence interval: 0.55-0.85; P = 7.95 x 10(-4)), primarily for adenocarcinoma.
|
19955392 |
2010 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In the subgroup analysis based on cancer type, the TERT rs2736098 with the A allele was 1.299 times more frequent than that with the G allele (OR = 1.299, 95% CI = 1.216-1.386) under the allelic genetic model in lung cancer, and 1.152 times (OR = 1.152, 95% CI = 1.032-1.286) that in bladder cancer.
|
29695979 |
2018 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In conclusion, in males, the TERT rs2736098 and CLPTM1L rs401681 T alleles are the susceptibility factors for developing lung cancer.
|
28789383 |
2017 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Twenty-two variants from 21 genes (APEX1 rs1130409 and rs1760944, ATM rs664677, AXIN2 rs2240308, CHRNA3 rs6495309, CHRNA5 rs16969968, CLPTM1L rs402710, CXCR2 rs1126579, CYP1A1 rs4646903, CYP2E1 rs6413432, ERCC1 rs11615, ERCC2 rs13181, FGFR4 rs351855, HYKK rs931794, MIR146A rs2910164, MIR196A2 rs11614913, OGG1 rs1052133, PON1 rs662, REV3L rs462779, SOD2 rs4880, TERT rs2736098, and TP53 rs1042522) showed significant associations with lung cancer susceptibility with strong cumulative epidemiological evidence.
|
28827732 |
2017 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Additionally, the association was more significant in Asians (OR=1.20; 95% CI=1.07-1.34), while in subsequent analyses stratified by cancer type, the variant rs2736098 was definitely associated with increased lung cancer (OR=1.18; 95% CI=1.07-1.29) and hepatocellular carcinoma risk (OR=1.38; 95% CI=1.20-1.59).
|
27273963 |
2016 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The TERT rs2736098 polymorphism might affect the susceptibility to lung cancer in Chinese populations.
|
24761905 |
2014 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The TERT-rs2736098 T allele was also associated with increased lung cancer risk both in adenocarcinoma and squamous cell carcinoma.
|
24861918 |
2014 |