Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10468017
rs10468017
ALDH1A2
0.890 GeneticVariation BEFREE The frequency of the allele T of rs10468017 (LIPC gene) was lower in dry AMD cases compared to controls (15.8 versus 27.9%, respectively: p = 8.4 × 10<sup>-3</sup> OR = 0.57, 95% CI: 0.33-0.98). 31654486

2019
dbSNP: rs10468017
rs10468017
ALDH1A2
0.890 GeneticVariation BEFREE The study showed that LIPC rs493258 gene and haplotype containing the two minor alleles T-T in rs10468017-rs493258 may decrease AMD development. 30399423

2019
dbSNP: rs10468017
rs10468017
ALDH1A2
0.890 GeneticVariation BEFREE We found no associations of <i>TLR3</i> (rs3775291), <i>CFD</i> (rs3826945), <i>FRK</i> (rs1999930) or <i>LIPC</i> (rs10468017) or <i>APOE</i> ε4 alleles with nvAMD or early AMD, nor between early AMD and rs1883025 or rs4711751. 29259020

2018
dbSNP: rs10468017
rs10468017
ALDH1A2
0.890 GeneticVariation BEFREE This meta-analysis revealed that both CETP rs3764261 and LIPC rs10468017 polymorphisms were significantly associated with AMD risk. 26503844

2015
dbSNP: rs10468017
rs10468017
ALDH1A2
0.890 GeneticVariation BEFREE Our meta-analysis indicates that LIPC rs10468017 variant is associated with a reduced risk of advanced AMD. 25010633

2014
dbSNP: rs10468017
rs10468017
ALDH1A2
0.890 GeneticVariation BEFREE Associations of LIPC rs10468017, CETP and ABCA1 polymorphisms with AMD did not reach statistical significance. 24223199

2013
dbSNP: rs10468017
rs10468017
ALDH1A2
0.890 GeneticVariation BEFREE The LIPC promoter variants rs493258 and rs10468017 were associated with advanced AMD in two independent Caucasian populations, confirming that LIPC polymorphisms may be a genetic risk factor for AMD in the Caucasian population. 23348725

2013
dbSNP: rs10468017
rs10468017
ALDH1A2
0.890 GeneticVariation GWASCAT Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. 21665990

2011
dbSNP: rs10468017
rs10468017
ALDH1A2
0.890 GeneticVariation GWASDB Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. 21665990

2011
dbSNP: rs10468017
rs10468017
ALDH1A2
0.890 GeneticVariation GWASCAT Our LIPC association was strongest for a functional promoter variant, rs10468017, (P = 1.34e-08), that influences LIPC expression and serum HDL levels with a protective effect of the minor T allele (HDL increasing) for advanced wet and dry AMD. 20385826

2010
dbSNP: rs10468017
rs10468017
ALDH1A2
0.890 GeneticVariation BEFREE Our LIPC association was strongest for a functional promoter variant, rs10468017, (P = 1.34e-08), that influences LIPC expression and serum HDL levels with a protective effect of the minor T allele (HDL increasing) for advanced wet and dry AMD. 20385826

2010
dbSNP: rs10468017
rs10468017
ALDH1A2
0.890 GeneticVariation BEFREE Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration. 21139980

2010
dbSNP: rs10468017
rs10468017
ALDH1A2
0.890 GeneticVariation GWASDB Our LIPC association was strongest for a functional promoter variant, rs10468017, (P = 1.34e-08), that influences LIPC expression and serum HDL levels with a protective effect of the minor T allele (HDL increasing) for advanced wet and dry AMD. 20385826

2010