Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6918679
rs6918679
A 0.700 GeneticVariation GWASCAT Genome-wide association study of treatment response to venlafaxine XR in generalized anxiety disorder. 28437668

2017

dbSNP: rs6265
rs6265
0.050 GeneticVariation BEFREE The present study showed that carrying the Met allele confers increased risk for the presence of generalized anxiety disorder (χ = 4.7, P = .03; OR (95%) 1.96 (1.05-3.56)) when patients with generalized anxiety disorder were compared with the comparison group.Our results provide evidence of an association between the Val66Met polymorphism of the BDNF gene and generalized anxiety disorder in a Mexican population. 30882674

2019

dbSNP: rs759834365
rs759834365
0.050 GeneticVariation BEFREE The present study showed that carrying the Met allele confers increased risk for the presence of generalized anxiety disorder (χ = 4.7, P = .03; OR (95%) 1.96 (1.05-3.56)) when patients with generalized anxiety disorder were compared with the comparison group.Our results provide evidence of an association between the Val66Met polymorphism of the BDNF gene and generalized anxiety disorder in a Mexican population. 30882674

2019

dbSNP: rs6265
rs6265
0.050 GeneticVariation BEFREE No significant difference was found in the BDNF Val66Met polymorphism between patients with GAD and healthy controls, nor was this polymorphism significantly associated with antidepressant drug efficacy for GAD. 29446659

2018

dbSNP: rs759834365
rs759834365
0.050 GeneticVariation BEFREE No significant difference was found in the BDNF Val66Met polymorphism between patients with GAD and healthy controls, nor was this polymorphism significantly associated with antidepressant drug efficacy for GAD. 29446659

2018

dbSNP: rs6265
rs6265
0.050 GeneticVariation BEFREE The Met allele of BDNF Val66Met polymorphism is associated with increased BDNF levels in generalized anxiety disorder. 26110341

2015

dbSNP: rs6265
rs6265
0.050 GeneticVariation BEFREE Val66Met variation was not associated with OCD or GAD. 26209750

2015

dbSNP: rs759834365
rs759834365
0.050 GeneticVariation BEFREE Val66Met variation was not associated with OCD or GAD. 26209750

2015

dbSNP: rs759834365
rs759834365
0.050 GeneticVariation BEFREE The Met allele of BDNF Val66Met polymorphism is associated with increased BDNF levels in generalized anxiety disorder. 26110341

2015

dbSNP: rs6265
rs6265
0.050 GeneticVariation BEFREE We did not find a significant association between rs6265 and antidepressant treatment response in our GAD population. 21889574

2011

dbSNP: rs759834365
rs759834365
0.050 GeneticVariation BEFREE Association analysis between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and treatment response to venlafaxine XR in generalized anxiety disorder. 21889574

2011

dbSNP: rs4680
rs4680
0.020 GeneticVariation BEFREE COMT rs4680 polymorphism was genotyped in 1,655 Han Chinese adults (1,142 healthy subjects and 513 patients with GAD; age: 20-65). 30954919

2019

dbSNP: rs4606
rs4606
0.020 GeneticVariation BEFREE Logistic regressions adjusted for sex and age revealed that rs4606 interacted with total childhood adversity in predicting each diagnostic outcome except for panic disorder and generalized anxiety disorder, uncorrected and corrected for multiple testing (odds ratio [OR] = 1.06-1.16). 30107643

2018

dbSNP: rs25531
rs25531
0.020 GeneticVariation BEFREE Utilizing a triallelic assay (5-HTTLPR and rs25531) to assess genetic variation linked with altered serotonin signaling, this fMRI study investigated genetic influences on amygdala and anterior insula activity in 50 generalized anxiety disorder patients, 26 of whom also met DSM-IV criteria for social anxiety disorder and/or major depressive disorder, and 39 healthy comparison subjects. 25675343

2015

dbSNP: rs25531
rs25531
0.020 GeneticVariation BEFREE We examined a possible interaction between the serotonin transporter gene (SLC6A4) 5-HTTLPR/rs25531 haplotype and the serotonin 2A receptor gene (HTR2A) single-nucleotide polymorphism (SNP) rs7997012 in antidepressant treatment outcome in GAD. 22907732

2013

dbSNP: rs7997012
rs7997012
0.020 GeneticVariation BEFREE We examined a possible interaction between the serotonin transporter gene (SLC6A4) 5-HTTLPR/rs25531 haplotype and the serotonin 2A receptor gene (HTR2A) single-nucleotide polymorphism (SNP) rs7997012 in antidepressant treatment outcome in GAD. 22907732

2013

dbSNP: rs7997012
rs7997012
0.020 GeneticVariation BEFREE We tested the hypothesis that the genetic polymorphism rs7997012 in the HTR2A gene predicts treatment outcome in GAD patients treated with venlafaxine XR. 22006095

2013

dbSNP: rs4680
rs4680
0.020 GeneticVariation BEFREE Furthermore, we show a slight dominant effect of the A-allele with the CGI-I measure in the European American population indicating a possible pharmacogenetic role of rs4680 in antidepressant treatment outcome in GAD. 22417933

2012

dbSNP: rs4606
rs4606
0.020 GeneticVariation BEFREE RGS2 SNP rs4606 was significantly associated with GAD in this sample. 18833580

2009

dbSNP: rs324981
rs324981
0.010 GeneticVariation BEFREE Association of NPSR1 rs324981 polymorphism and treatment response to antidepressants in Chinese Han population with generalized anxiety disorder. 30190127

2018

dbSNP: rs11568817
rs11568817
0.010 GeneticVariation BEFREE In women with ADHD, the same rs11568817 was associated with generalized anxiety disorder (P<sub>corr</sub> = 0.031). 28923721

2017

dbSNP: rs78602344
rs78602344
0.010 GeneticVariation BEFREE One genotyped SNP (rs78602344) intronic to thrombospondin 2 (THBS2) was nominally associated (P = 5.28 × 10<sup>-8</sup> ) in the primary analysis adjusting for psychiatric medication use and significantly associated with the GAD symptoms score in the analysis excluding medication users (P = 4.18 × 10<sup>-8</sup> ). 27159506

2017

dbSNP: rs1043307
rs1043307
0.010 GeneticVariation BEFREE In our study, the PSMD9 gene SNPs rs74421874, rs3825172, and rs1043307/rs2514259 result in linkage to generalized anxiety disorder. 24648162

2014

dbSNP: rs14259
rs14259
0.010 GeneticVariation BEFREE The 200 Italians families were tested for the PSMD9 T2D risk SNPs rs74421874 (IVS3 + nt460 G>A), rs3825172 (IVS3 +nt437 T>C) and for the T2D risk and anti-depressant response SNP rs1043307/rs2514259 (E197G A>G) for evidence of linkage with generalized anxiety disorder. 24648162

2014

dbSNP: rs2514259
rs2514259
AIP
0.010 GeneticVariation BEFREE In our study, the PSMD9 gene SNPs rs74421874, rs3825172, and rs1043307/rs2514259 result in linkage to generalized anxiety disorder. 24648162

2014