Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs199474657
rs199474657
ND1 ; ND2 ; TRNL1
G 0.700 CausalMutation CLINVAR

dbSNP: rs7903146
rs7903146
0.040 GeneticVariation BEFREE The rs7903146 variant in the <i>TCF7L2</i> gene increases the risk of IGT/T2D in obese adolescents by impairing β-cell function, and hepatic insulin sensitivity predicts the development of IGT/T2D over time. 28611053

2017

dbSNP: rs1801282
rs1801282
0.040 GeneticVariation BEFREE The P12A rare g allele was present in 12% patients with normal glucose metabolism, 11% patients with impaired glucose tolerance or impaired fasting glucose, and 35% patients with diabetes (p=0.014). 21877956

2012

dbSNP: rs1805192
rs1805192
0.040 GeneticVariation BEFREE The P12A rare g allele was present in 12% patients with normal glucose metabolism, 11% patients with impaired glucose tolerance or impaired fasting glucose, and 35% patients with diabetes (p=0.014). 21877956

2012

dbSNP: rs7903146
rs7903146
0.040 GeneticVariation BEFREE Despite no associations between incidence of glucose intolerance and SNPs of the TCF7L2 gene in Japanese-Brazilians, we found that carriers of the CT genotype for rs7903146 had significantly lower insulin levels 2 h after a 75-g glucose load than carriers of the CC genotype. 21399856

2011

dbSNP: rs1801282
rs1801282
0.040 GeneticVariation BEFREE The proline allele at PPARG P12A increases risk for diabetes in persons with impaired glucose tolerance, an effect modified by body mass index. 17213274

2007

dbSNP: rs1805192
rs1805192
0.040 GeneticVariation BEFREE The proline allele at PPARG P12A increases risk for diabetes in persons with impaired glucose tolerance, an effect modified by body mass index. 17213274

2007

dbSNP: rs7903146
rs7903146
0.040 GeneticVariation BEFREE In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been also associated with a lower body mass index (BMI) in T2D individuals and with a smaller waist circumference in subjects with impaired glucose tolerance. 17593304

2007

dbSNP: rs1801282
rs1801282
0.040 GeneticVariation BEFREE Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. 16804087

2006

dbSNP: rs1805192
rs1805192
0.040 GeneticVariation BEFREE Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. 16804087

2006

dbSNP: rs7903146
rs7903146
0.040 GeneticVariation BEFREE Over an average period of three years, participants with the risk-conferring TT genotype at rs7903146 were more likely to have progression from impaired glucose tolerance to diabetes than were CC homozygotes (hazard ratio, 1.55; 95 percent confidence interval, 1.20 to 2.01; P<0.001). 16855264

2006

dbSNP: rs1801282
rs1801282
0.040 GeneticVariation BEFREE Allele frequencies of the Pro12Ala missense mutation of PPARgamma2 were not different among Korean subjects with normal glucose tolerance (qAla = 0.045), those with impaired glucose tolerance (qAla = 0.033), and those with diabetes mellitus (qAla = 0.043; P > 0.05). 10843155

2000

dbSNP: rs1805192
rs1805192
0.040 GeneticVariation BEFREE Allele frequencies of the Pro12Ala missense mutation of PPARgamma2 were not different among Korean subjects with normal glucose tolerance (qAla = 0.045), those with impaired glucose tolerance (qAla = 0.033), and those with diabetes mellitus (qAla = 0.043; P > 0.05). 10843155

2000

dbSNP: rs1232898090
rs1232898090
0.030 GeneticVariation BEFREE The P12A rare g allele was present in 12% patients with normal glucose metabolism, 11% patients with impaired glucose tolerance or impaired fasting glucose, and 35% patients with diabetes (p=0.014). 21877956

2012

dbSNP: rs12255372
rs12255372
0.030 GeneticVariation BEFREE Therefore, the aim of the present study was to assess whether two single-nucleotide polymorphisms (SNPs) of TCF7L2, rs7903146 and rs12255372, could predict the development of glucose intolerance in Japanese-Brazilians. 21399856

2011

dbSNP: rs5219
rs5219
0.030 GeneticVariation BEFREE The KCNJ11 E23K and ABCC8 exon 31 variants contribute to susceptibility to T2D diabetes, glucose intolerance and altered insulin secretion in a Russian population. 18758683

2009

dbSNP: rs5219
rs5219
0.030 GeneticVariation BEFREE We conclude that the lysine variant in KCNJ11 E23K leads to diminished insulin secretion in individuals with IGT. 17259403

2007

dbSNP: rs12255372
rs12255372
0.030 GeneticVariation BEFREE We examined whether the two most strongly associated variants (rs12255372 and rs7903146) predict the progression to diabetes in persons with impaired glucose tolerance who were enrolled in the Diabetes Prevention Program, in which lifestyle intervention or treatment with metformin was compared with placebo. 16855264

2006

dbSNP: rs12255372
rs12255372
0.030 GeneticVariation BEFREE We genotyped four of the SNPs (rs7901695, rs7903146, rs11196205, and rs12255372) in Amish subjects with type 2 diabetes (n = 137), impaired glucose tolerance (IGT; n = 139), and normal glucose tolerance (NGT; n = 342). 16936218

2006

dbSNP: rs1232898090
rs1232898090
0.030 GeneticVariation BEFREE Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial. 15592662

2004

dbSNP: rs5219
rs5219
0.030 GeneticVariation BEFREE We conclude that the polymorphisms of the SUR1 gene predicted the conversion from impaired glucose tolerance to type 2 diabetes and that the effect of these polymorphisms on diabetes risk was additive with the E23K polymorphism of the Kir6.2 gene. 15579791

2004

dbSNP: rs1232898090
rs1232898090
0.030 GeneticVariation BEFREE The association of the Pro12Ala polymorphism of the PPAR-gamma2 gene with the incidence of type 2 diabetes was investigated in 522 subjects with impaired glucose tolerance (IGT) participating in the Finnish Diabetes Prevention Study. 12145174

2002

dbSNP: rs1801483
rs1801483
0.030 GeneticVariation BEFREE A total of 348 unrelated Japanese subjects (220 with NIDDM, 53 with impaired glucose tolerance (IGT) and 75 normal subjects) were screened for the presence of the Gly40-Ser mutation. 8879960

1996

dbSNP: rs1801483
rs1801483
0.030 GeneticVariation BEFREE Absence of association between the Gly40-->Ser mutation in the human glucagon receptor and Japanese patients with non-insulin-dependent diabetes mellitus or impaired glucose tolerance. 8931690

1996

dbSNP: rs1801483
rs1801483
0.030 GeneticVariation BEFREE Taken together, the data do not support the suggested involvement of the Gly40Ser polymorphism in impaired glucose tolerance and the hypothesis of an association between NIDDM and the glucagon receptor gene in this population. 8690179

1995