|
rs699947
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In summary, our study showed evidence that the VEGF rs699947 polymorphism was obviously associated with an increased risk of bladder cancer and renal cell carcinoma, particularly in Asian population, while no significant association was observed in overall urologic neoplasms.
|
30195633 |
2018 |
|
rs699947
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The pooled OR indicated that rs699947 polymorphism was significantly associated with RCC risk in all genetic models.
|
28356760 |
2017 |
|
rs699947
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that there may be a relationship between the VEGF rs2010963, rs3025039 and rs699947 polymorphisms and RCC susceptibility.
|
28562357 |
2017 |
|
rs718314
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The authors observed evidence of interactions between PhIP and RCC susceptibility variants in 2 genes: inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) (rs718314; multiplicative P for interaction = .03 and additive P for interaction =.002) and endothelial PAS domain-containing protein 1 (EPAS1) (rs7579899; additive P for interaction =.06).
|
26551148 |
2016 |
|
rs718314
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The 12p11.23 variant rs10771279, located 77 kb from the European-ancestry RCC marker rs718314, was associated with RCC risk in the GWAS (P = 1.2 × 10(-7)) but did not replicate (P = 0.99).
|
24220910 |
2014 |
|
rs718314
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A variant (rs718314) in the inositol 1,4,5-trisphosphate receptor, type 2 gene (ITPR2) was found to interact with the American/Western dietary pattern in relation to RCC risk (additive Pinteraction = 0.03).
|
25053674 |
2014 |
|
rs718314
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We identified two common variants in linkage disequilibrium, rs718314 and rs1049380 (r(2) = 0.64, D ' = 0.84), in the inositol 1,4,5-triphosphate receptor, type 2 (ITPR2) gene on 12p11.23 as novel susceptibility loci for RCC (P = 8.89 × 10(-10) and P = 6.07 × 10(-9), respectively, in meta-analysis) with an allelic odds ratio of 1.19 [95% confidence interval (CI): 1.13-1.26] for rs718314 and 1.18 (95% CI: 1.12-1.25) for rs1049380.
|
22010048 |
2012 |
|
rs10069690
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This meta-analysis suggested that the TERT rs10069690 polymorphism may be a risk factor for cancer, especially breast cancer, ovarian cancer, lung cancer, thyroid cancer, and RCC.
|
31454181 |
2019 |
|
rs1801133
|
|
|
0.030 |
GeneticVariation |
BEFREE |
However, methylenetetrahydrofolate reductase (rs1801133 and rs1801131), vitamin D receptor (TaqI and Fok1), and interleukin-16 (rs4778889 and rs11556218) gene polymorphisms were not associated with the risk of renal cell carcinoma.
|
31242814 |
2019 |
|
rs11549465
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This meta-analysis was performed to assess the relationship between HIF-1α C1772T (rs11549465)/G1790A (rs11549467) gene polymorphism and RCC risk.
|
30539853 |
2018 |
|
rs10069690
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Rs35073794, rs10936599 and rs10069690 were positively correlated with the age older than 55 (OR= 3.27, 95%CI= 1.08-9.93, <i>p</i>=0.031; OR= 1.56, 95%CI= 1.03-2.37, <i>p=</i> 0.034; OR= 4.94, 95%CI= 1.18-20.70, <i>p=</i> 0.022, respectively) with or without history of drinking(OR= 4.47, 95%CI= 0.99-20.25, <i>p=</i> 0.024<i>;</i> OR= 2.62, 95%CI= 1.13-6.08, <i>p=</i> 0.022<i>;</i> OR=2.44, 95%CI=1.03-5.78, <i>p</i>= 0.04, respectively) and clinical stage I/II RCC (OR=2.62, 95%CI=1.02-6.74, <i>p</i>= 0.045; OR= 2.23, 95%CI= 1.08-4.60, <i>p=</i> 0.028; OR= 1.63, 95%CI= 1.17-2.27, <i>p</i>= 0.014, respectively).
|
29100352 |
2017 |
|
rs11549465
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These results suggest that HIF1A+1772C/T (rs11549465) polymorphism may have effects on RCC recurrence/progression and survival.
|
28476527 |
2017 |
|
rs1222213359
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Moreover, VEGF -1154G/A and -634C/G polymorphisms were found significantly associated with poor OS of RCC.
|
28489583 |
2017 |
|
rs2010963
|
|
|
0.030 |
GeneticVariation |
BEFREE |
As to rs1570360 or rs2010963, we did not observe any relationship between the two polymorphisms and RCC risk in our study.
|
28356760 |
2017 |
|
rs2010963
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that there may be a relationship between the VEGF rs2010963, rs3025039 and rs699947 polymorphisms and RCC susceptibility.
|
28562357 |
2017 |
|
rs3025039
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the meanwhile, this study also demonstrated that the allele contrast model of rs3025039 polymorphism was likely to be associated with risk of RCC in the Asian population.
|
28356760 |
2017 |
|
rs3025039
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that there may be a relationship between the VEGF rs2010963, rs3025039 and rs699947 polymorphisms and RCC susceptibility.
|
28562357 |
2017 |
|
rs10069690
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Rs2736100, rs7726159, rs2853677, rs13172201, and rs10069690 were not linked with RCC risk, and none of the polymorphisms was associated with RCC pathology.
|
26294352 |
2016 |
|
rs11762213
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The exonic MET variant rs11762213 is an independent predictor of adverse CSS and TTR in ccRCC and should be integrated into clinical practice for prognostic stratification.
|
26505625 |
2016 |
|
rs7579899
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The authors observed evidence of interactions between PhIP and RCC susceptibility variants in 2 genes: inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) (rs718314; multiplicative P for interaction = .03 and additive P for interaction =.002) and endothelial PAS domain-containing protein 1 (EPAS1) (rs7579899; additive P for interaction =.06).
|
26551148 |
2016 |
|
rs132770
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Sensitivity analyses were also performed.The rs2267437 polymorphism was associated with a significant increase in risks of overall cancers, breast cancer, renal cell carcinoma and hepatocellular carcinoma, and it could increase the cancer risk in Asian population; the rs5751129 polymorphism could increase the cancer risk in overall cancers; the rs132770 polymorphism was associated with the increased renal cell carcinoma risk; furthermore, the rs132793 polymorphism could decrease breast cancer risk and increase risks in "other cancers".Overall, the results provided evidences that the single nucleotide polymorphisms in XRCC6 promoter region might play different roles in various cancers, indicating different cancers have different tumorigenesis mechanisms.
|
25569644 |
2015 |
|
rs1801133
|
|
|
0.030 |
GeneticVariation |
BEFREE |
While, allele T of MTHFR rs1801133 could decrease the risk of RCC (OR=0.62, 95% CI=0.40-0.97).
|
26191297 |
2015 |
|
rs2267437
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Sensitivity analyses were also performed.The rs2267437 polymorphism was associated with a significant increase in risks of overall cancers, breast cancer, renal cell carcinoma and hepatocellular carcinoma, and it could increase the cancer risk in Asian population; the rs5751129 polymorphism could increase the cancer risk in overall cancers; the rs132770 polymorphism was associated with the increased renal cell carcinoma risk; furthermore, the rs132793 polymorphism could decrease breast cancer risk and increase risks in "other cancers".Overall, the results provided evidences that the single nucleotide polymorphisms in XRCC6 promoter region might play different roles in various cancers, indicating different cancers have different tumorigenesis mechanisms.
|
25569644 |
2015 |
|
rs11762213
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Patients with localised renal-cell carcinoma and the MET polymorphism rs11762213 might have an increased risk of recurrence after nephrectomy.
|
24767687 |
2014 |
|
rs1222213359
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, our study presented the factors regarding the prognosis of RCC patients, and high platelet and neutrophil counts, low lymphocytes, and VEGF -2578C/A and -1154G/A polymorphisms were shown to be independent factors for a lower prognosis of RCC patients.
|
25062489 |
2014 |