Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation BEFREE 18F-RB390: innovative ligand for imaging the T877A androgen receptor mutant in prostate cancer via positron emission tomography (PET). 25358634

2015

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation BEFREE Proteomic-coupled-network analysis of T877A-androgen receptor interactomes can predict clinical prostate cancer outcomes between White (non-Hispanic) and African-American groups. 25409505

2015

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation BEFREE It may be particularly effective against prostate cancer cells with the T878A AR mutation but may also enhance degradation of wild-type AR in vivo through a combination of direct and indirect mechanisms. 24874833

2015

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation UNIPROT Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. 25091737

2014

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation BEFREE Here, we demonstrate that genistein, a soy phytoestrogen binds to both the wild and the Thr877Ala (T877A) mutant types of AR competitively with androgen, nevertheless, it exerts a pleiotropic effect on PCa cell proliferation and AR activity depending on the mutational status of the AR. 24167630

2014

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation BEFREE A total of four human prostate cancer cell models were examined: LNCaP (T877A mutant AR), 22Rv1 (H874Y mutant AR), LAPC4 (wild-type AR), and VCaP (wild-type AR). 23813737

2013

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation BEFREE BPA and DHT elicited distinct transcriptional signatures in prostate cancer cells expressing the BPA-responsive mutant AR-T877A. 18007998

2008

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation BEFREE Thus, our findings suggest that the WT AR inhibits expression of hTERT, which is indicative of a protective mechanism, whereas the T877A mutation of AR not only broadens the ligand spectrum of the receptor but abrogates this inhibitory mechanism in prostate cancer cells. 17991730

2008

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation UNIPROT Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design. 17311914

2007

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation BEFREE Androgen receptor mutation (T877A) promotes prostate cancer cell growth and cell survival. 16636679

2006

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation UNIPROT Structural basis for accommodation of nonsteroidal ligands in the androgen receptor. 16129672

2006

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation BEFREE The T877A mutant of the AR frequently found in advanced cases of prostate cancer displays an exaggerated stimulation of transcriptional activity by CDK6. 15790678

2005

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation BEFREE The mutant androgen receptor T877A mediates the proliferative but not the cytotoxic dose-dependent effects of genistein and quercetin on human LNCaP prostate cancer cells. 12391264

2002

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation BEFREE This mutant AR contains two mutations (L701H and T877A) and was previously reported as a high-affinity cortisol/cortisone responsive AR (AR(ccr)) isolated from the androgen-independent human prostate cancer cell lines MDA PCa 2a and 2b (Zhao et al.Nature Med.2000, 6, 703-6). 11906285

2002

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation BEFREE The cortisol/cortisone-responsive AR (AR(ccr)) has two mutations (L701H and T877A) that were found in the MDA PCa human prostate cancer cell lines established from a castrated patient whose metastatic tumor exhibited androgen-independent growth. 11956172

2002

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation UNIPROT Two mutations identified in the androgen receptor of the new human prostate cancer cell line MDA PCa 2a. 10569618

2000

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation UNIPROT Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. 10363963

1999

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation UNIPROT Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: relation to antiandrogen withdrawal syndrome. 8827083

1996

dbSNP: rs137852578
rs137852578
AR
0.900 CausalMutation CLINVAR Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers. 8187068

1994

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation UNIPROT Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers. 8187068

1994

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation UNIPROT Androgen receptor gene mutations in human prostate cancer. 8274409

1994

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation UNIPROT The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens. 1562539

1992

dbSNP: rs137852578
rs137852578
AR
0.900 GeneticVariation UNIPROT A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens. 2260966

1991

dbSNP: rs864622007
rs864622007
AR
0.830 GeneticVariation CLINVAR Integrated clinical, whole-genome, and transcriptome analysis of multisampled lethal metastatic prostate cancer. 27148588

2016

dbSNP: rs864622007
rs864622007
AR
0.830 GeneticVariation BEFREE Systematic structure-function analysis of androgen receptor Leu701 mutants explains the properties of the prostate cancer mutant L701H. 20007693

2010