Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
MTHFR
0.020 GeneticVariation BEFREE Differential effects of the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) on hematological malignancies among Latinos: a meta-analysis. 31188929

2019
dbSNP: rs397507444
rs397507444
MTHFR
0.010 GeneticVariation BEFREE Differential effects of the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) on hematological malignancies among Latinos: a meta-analysis. 31188929

2019
dbSNP: rs2285489
rs2285489
ADAMTS13
0.010 GeneticVariation BEFREE We retrospectively examined whether <i>ADAMTS13</i> rs2285489 affected the transplant outcomes in a cohort of 281 patients who underwent unrelated human leukocyte antigen (HLA)-matched bone marrow transplantation for hematologic malignancies. 30626079

2019
dbSNP: rs121913507
rs121913507
KIT
0.010 GeneticVariation BEFREE The findings also suggest that targeting the SPHK/S1P axis may provide an alternative to tyrosine kinase inhibitors, alone or in combination, for the treatment of aggressive mastocytosis and other hematological malignancies associated with the D816V-KIT mutation. 29643855

2018
dbSNP: rs121913682
rs121913682
KIT
0.010 GeneticVariation BEFREE The findings also suggest that targeting the SPHK/S1P axis may provide an alternative to tyrosine kinase inhibitors, alone or in combination, for the treatment of aggressive mastocytosis and other hematological malignancies associated with the D816V-KIT mutation. 29643855

2018
dbSNP: rs1800023
rs1800023
CCR5 ; CCR5AS
0.010 GeneticVariation BEFREE We retrospectively examined the impact of the CCR5 variation (rs1800023, -2086A>G) on transplant outcomes in a cohort of 329 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies through the Japan Marrow Donor Program. 28487238

2017
dbSNP: rs11536889
rs11536889
TLR4
0.010 GeneticVariation BEFREE We retrospectively examined whether or not genetic variations in toll-like receptor 1 (rs5743551, -7202GQ>A), toll-like receptor 2 (rs7656411, 22215G>T), and toll-like receptor 4 (rs11536889, +3725G>C) affected transplant outcomes in a cohort of 365 patients who underwent unrelated HLA-matched bone marrow transplantation (for hematologic malignancies through the Japan Marrow Donor Program. 28484092

2017
dbSNP: rs5743551
rs5743551
TLR1
0.010 GeneticVariation BEFREE We retrospectively examined whether or not genetic variations in toll-like receptor 1 (rs5743551, -7202GQ>A), toll-like receptor 2 (rs7656411, 22215G>T), and toll-like receptor 4 (rs11536889, +3725G>C) affected transplant outcomes in a cohort of 365 patients who underwent unrelated HLA-matched bone marrow transplantation (for hematologic malignancies through the Japan Marrow Donor Program. 28484092

2017
dbSNP: rs7656411
rs7656411
TLR2
0.010 GeneticVariation BEFREE We retrospectively examined whether or not genetic variations in toll-like receptor 1 (rs5743551, -7202GQ>A), toll-like receptor 2 (rs7656411, 22215G>T), and toll-like receptor 4 (rs11536889, +3725G>C) affected transplant outcomes in a cohort of 365 patients who underwent unrelated HLA-matched bone marrow transplantation (for hematologic malignancies through the Japan Marrow Donor Program. 28484092

2017
dbSNP: rs1801157
rs1801157
CXCL12
0.010 GeneticVariation BEFREE Several recent studies have shown that <i>SDF1</i>-3'A polymorphism (rs1801157) is associated with susceptibility to hematological malignancy, but published studies' results are disputed. 28352190

2017
dbSNP: rs1057520009
rs1057520009
XPO1
0.010 GeneticVariation BEFREE Recent reports have shown molecular alterations in the gene encoding XPO1 and showed a mutation hotspot (E571K) in the following two hematological malignancies with similar phenotypes and natural histories: primary mediastinal diffuse large B cell lymphoma and classical Hodgkin's lymphoma. 28196522

2017
dbSNP: rs1217691063
rs1217691063
MTHFR
0.020 GeneticVariation BEFREE MTHFR C677T polymorphism may be a good predictor for MTX toxicity in adult hematological malignancies. 27270164

2016
dbSNP: rs387907272
rs387907272
MYD88
0.020 GeneticVariation BEFREE However, the seminal discoveries of MYD88 (L265P) mutation, present in the vast majority (85-100 %), and CXCR4 (WHIM) mutations, identified in nearly a third of patients (who almost exclusively harbor the MYD88 (L265P) variant), have laid a solid foundation for a paradigm shift in our diagnostic and therapeutic approaches towards this rare hematologic malignancy. 26942591

2016
dbSNP: rs1057519766
rs1057519766
FLT3
0.010 GeneticVariation BEFREE Three out of 14 (21.4 %) C57BL/6J mice transplanted with FLT3-N676K-transduced primary hematopoietic progenitor cells developed acute leukemia (latency of 68, 77, and 273 days), while no hematological malignancy was observed in the control groups including FLT3-ITD. 26891877

2016
dbSNP: rs767464424
rs767464424
CEBPZ
0.010 GeneticVariation BEFREE Three out of 14 (21.4 %) C57BL/6J mice transplanted with FLT3-N676K-transduced primary hematopoietic progenitor cells developed acute leukemia (latency of 68, 77, and 273 days), while no hematological malignancy was observed in the control groups including FLT3-ITD. 26891877

2016
dbSNP: rs777017502
rs777017502
CEBPZ
0.010 GeneticVariation BEFREE Three out of 14 (21.4 %) C57BL/6J mice transplanted with FLT3-N676K-transduced primary hematopoietic progenitor cells developed acute leukemia (latency of 68, 77, and 273 days), while no hematological malignancy was observed in the control groups including FLT3-ITD. 26891877

2016
dbSNP: rs1042522
rs1042522
TP53
0.020 GeneticVariation BEFREE R72P associations with specific cancer risk, particularly hematological malignancies, have been conflicting. 25768405

2015
dbSNP: rs1131691014
rs1131691014
TP53
0.020 GeneticVariation BEFREE R72P associations with specific cancer risk, particularly hematological malignancies, have been conflicting. 25768405

2015
dbSNP: rs878854066
rs878854066
TP53
0.020 GeneticVariation BEFREE R72P associations with specific cancer risk, particularly hematological malignancies, have been conflicting. 25768405

2015
dbSNP: rs25487
rs25487
XRCC1
0.010 GeneticVariation BEFREE The current meta-analysis indicated that the Arg399Gln polymorphism in the XRCC1 gene might be a risk factor for hematological malignancies in Asians or for leukemia. 25619474

2015
dbSNP: rs724159945
rs724159945
ETV6
T 0.700 CausalMutation CLINVAR Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy. 25581430

2015
dbSNP: rs724159946
rs724159946
ETV6
A 0.700 CausalMutation CLINVAR Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy. 25581430

2015
dbSNP: rs724159947
rs724159947
ETV6
T 0.700 GeneticVariation CLINVAR Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy. 25581430

2015
dbSNP: rs13347
rs13347
CD44
0.010 GeneticVariation BEFREE In conclusion, our results indicate that among investigated single nucleotide polymorphisms (SNPs), only CD44 rs13347 has an impact on the efficacy of HSCs mobilization in patients with hematologic malignancies. 24680978

2014
dbSNP: rs1799782
rs1799782
XRCC1
0.010 GeneticVariation BEFREE The current meta-analysis indicated that the Arg194Trp polymorphism in the XRCC1 gene might be not a risk factor for hematological malignancies. 24414482

2014