|
rs1800562
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The mild iron overload associated with heterozygosity for C282Y HFE mutation confers susceptibility to nonalcoholic fatty liver disease, causing relative insulin deficiency.
|
12779071 |
2003 |
|
rs1800562
|
|
|
0.070 |
GeneticVariation |
BEFREE |
However, it is currently unresolved whether mild-to-moderate hepatic iron deposition or heterozygosity for the C282Y mutation plays a role in human alcoholic liver disease or in nonalcoholic fatty liver disease or nonalcoholic steatohepatitis.
|
12957298 |
2003 |
|
rs1800562
|
|
|
0.070 |
GeneticVariation |
BEFREE |
To assess the prevalence of the two mutations, C282Y and H63D of HFE gene, in healthy subjects, patients with chronic hepatitis C (CHC), and patients with nonalcoholic fatty liver disease (NAFLD) in Taiwan and to explore the contribution of the HFE mutation on serum iron stores in CHC and NAFLD groups.
|
15991291 |
2005 |
|
rs1799945
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The prevalence of H63D heter-ozygosity was 4/125 (3.20%) in healthy subjects, 2/29 (6.90%) in CHC group, and 1/33 (3.03%) in NAFLD group.
|
15991291 |
2005 |
|
rs7946
|
|
|
0.020 |
GeneticVariation |
BEFREE |
For the first time we report that a polymorphism of the human PEMT gene (V175M) is associated with diminished activity and may confer susceptibility to NAFLD.
|
16051693 |
2005 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
According to this study, the MTHFR C677T mutation does not seem to be a risk factor for the progression of NAFL to NASH.
|
17356914 |
2007 |
|
rs11932595
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs11932595 and rs6843722 showed significant associations with NAFLD (empiric P = 0.0449 and 0.023, respectively).
|
17696255 |
2007 |
|
rs1554483
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association was also observed between clinical or histologic spectrum of NAFLD and rs1554483 (empiric P = 0.0399), rs6843722 (empiric P = 0.0229) and rs6850524 (empiric P = 0.00899) and between fibrosis score and rs1554483 (empiric P = 0.02697), rs6843722 (empiric P = 0.01898) and rs4864548 (empiric P = 0.02697).
|
17696255 |
2007 |
|
rs4864548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association was also observed between clinical or histologic spectrum of NAFLD and rs1554483 (empiric P = 0.0399), rs6843722 (empiric P = 0.0229) and rs6850524 (empiric P = 0.00899) and between fibrosis score and rs1554483 (empiric P = 0.02697), rs6843722 (empiric P = 0.01898) and rs4864548 (empiric P = 0.02697).
|
17696255 |
2007 |
|
rs6843722
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association was also observed between clinical or histologic spectrum of NAFLD and rs1554483 (empiric P = 0.0399), rs6843722 (empiric P = 0.0229) and rs6850524 (empiric P = 0.00899) and between fibrosis score and rs1554483 (empiric P = 0.02697), rs6843722 (empiric P = 0.01898) and rs4864548 (empiric P = 0.02697).
|
17696255 |
2007 |
|
rs6850524
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association was also observed between clinical or histologic spectrum of NAFLD and rs1554483 (empiric P = 0.0399), rs6843722 (empiric P = 0.0229) and rs6850524 (empiric P = 0.00899) and between fibrosis score and rs1554483 (empiric P = 0.02697), rs6843722 (empiric P = 0.01898) and rs4864548 (empiric P = 0.02697).
|
17696255 |
2007 |
|
rs2290602
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs2290602 had the lowest p value in the dominant mode (p = 0.00095), and the odds ratio for NAFLD (95% CI) was 2.73 (1.48 - 5.06). rs2290602 was significantly associated with NAFLD even when the most conservative Bonferroni's correction was applied (p = 0.0143).
|
18588668 |
2008 |
|
rs1805096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variant frequency at nucleotide 3057 G-->A transversion was 76.0% in type 2 diabetic patients complicated with NAFLD, which was also significantly higher than those without NAFLD (62.1%) and NGT cases (53.2%).
|
18713300 |
2009 |
|
rs6503695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In univariate analysis, there were significant differences in the allele frequency of the rs6503695 and rs9891119 between the healthy individuals and NA</span>FLD patients (empiric P=0.021 and 0.020, respectively).
|
18789715 |
2008 |
|
rs9891119
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When we tested the hypothesis of a relation between the gene variants and the clinical and histological spectrum of NAFLD by multinomial analysis, a sig</span>nificant association was observed with rs9891119 (P=0.02).
|
18789715 |
2008 |
|
rs6006460
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Resequencing revealed another allele of PNPLA3 (rs6006460[T], encoding S453I) that was associated with lower hepatic fat content in African Americans, the group at lowest risk of NAFLD.
|
18820647 |
2008 |
|
rs1800234
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PPAR-alpha val227ala polymorphism may be involved in the pathogenesis of NAFLD and play a protective role in obesity.
|
18853997 |
2008 |
|
rs17222723
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When we tested the hypothesis of a relation between gene variants and the clinical and histological spectra of NAFLD by multinomial regression analysis, a significant association was observed with the same markers: rs1</span>7222723 (P=.0029) and rs8187710 (P=.015).
|
18926681 |
2009 |
|
rs8187710
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When we tested the hypothesis of a relation between gene variants and the clinical and histological spectra of NAFLD by multinomial regression analysis, a significant association was observed with the same markers: rs17222723 (P=.0029) and rs8187710 (P=.015).
|
18926681 |
2009 |
|
rs2241766
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The T45G and G276T of the adiponectin gene may not be the important determinants of NAFLD in Chinese people, but some of them still influence serum ALT, BMI, IR, lipid, glucose metabolism and plasma adiponectin concentration.
|
19246975 |
2008 |
|
rs2276736
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Five SNPs (rs3772622, rs3772633, rs2276736, rs3772630 and rs3772627) were significantly associated with NAFLD, even when the most conservative Bonferroni's correction was applied.
|
19302184 |
2009 |
|
rs3772627
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Five SNPs (rs3772622, rs3772633, rs2276736, rs3772630 and rs3772627) were significantly associated with NAFLD, even when the most conservative Bonferroni's correction was applied.
|
19302184 |
2009 |
|
rs1412189378
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In 114 subjects with NAFLD we report the prevalence and correlation with clinical parameters of three polymorphisms: interleukin-6 (-174G/C), plasma cell differentiation antigen (K121Q) and microsomal transfer protein (-493G/T).
|
19403348 |
2009 |
|
rs17107315
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found two cases with a SNP at N34S location in NAFLD group (allele frequency %4).
|
19502653 |
2009 |
|
rs738409
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our aims were to develop a method to accurately predict non-alcoholic fatty liver disease (NAFLD) and liver fat content based on routinely available clinical and laboratory data and to test whether knowledge of the recently discovered genetic variant in the PNPLA3 gene (rs738409) increases accuracy of the prediction.
|
19524579 |
2009 |