|
rs7674434
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>KLB</i> rs7674434 and rs12152703 had associations with alanine aminotransferase (ALT) (<i>P</i> = 0.03 and <i>P</i> = 0.04, respectively) and gamma-glutamyltransferase (<i>P</i> = 0.03 and <i>P</i> = 0.02, respectively) levels in all subjects, but the associations were especially strong with ALT in the NAFLD group (<i>P</i> = 0.005 and <i>P</i> = 0.008, respectively).
|
31548436 |
2019 |
|
rs12152703
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>KLB</i> rs7674434 and rs12152703 had associations with alanine aminotransferase (ALT) (<i>P</i> = 0.03 and <i>P</i> = 0.04, respectively) and gamma-glutamyltransferase (<i>P</i> = 0.03 and <i>P</i> = 0.02, respectively) levels in all subjects, but the associations were especially strong with ALT in the NAFLD group (<i>P</i> = 0.005 and <i>P</i> = 0.008, respectively).
|
31548436 |
2019 |
|
rs4823173
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<i>PNPLA3</i> SNPs (rs139051, rs738408, rs738409, rs 2072906, rs2294918, rs2294919, and rs4823173) demonstrated extensive association with the serum lipidomics, especially phospholipid metabolites [lysophosphatidylcholine (LPC), lysophosphatidylcholine plasmalogen (LPCO), lysophosphatdylethanolamine (LPE), phosphatidylcholine (PC), choline plasmalogen (PCO), phosphatidylethanolamine (PE), ethanolamine plasmalogen (PEO)], of NAFLD patients.
|
30283798 |
2018 |
|
rs738409
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Non-alcoholic fatty liver disease (NAFLD) is commonly diagnosed in patients with obesity and type 2 diabetes mellitus (T2DM), and has been associated with the single nucleotide polymorphism (SNP) rs738409 in the PNPLA3 gene.
|
21665509 |
2011 |
|
rs738409
|
|
|
0.900 |
GeneticVariation |
BEFREE |
NAFLD is further favored by the patatin-like phospholipase domain-containing 3 (PNPLA3) p.I148M, transmembrane 6 superfamily member 2 (TM6SF2) p.E167K, and membrane-bound O-acyltransferase domain containing 7 (MBOAT7) rs641738 variants.
|
27576208 |
2016 |
|
rs1420472625
|
|
|
0.040 |
GeneticVariation |
BEFREE |
NAFLD is further favored by the patatin-like phospholipase domain-containing 3 (PNPLA3) p.I148M, transmembrane 6 superfamily member 2 (TM6SF2) p.E167K, and membrane-bound O-acyltransferase domain containing 7 (MBOAT7) rs641738 variants.
|
27576208 |
2016 |
|
rs738409
|
|
|
0.900 |
GeneticVariation |
BEFREE |
NAFLD association of PNPLA3 rs738409 was more pronounced among lean individuals (one-tailed p < 0.05) compared to the whole cohort sample.
|
30539516 |
2019 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
NAFLD was strongly associated with three genetic variants, TM6SF2 rs58542926, PNPLA3 rs738409 and GCKR rs1260326, and more slightly with ELOVL2 rs2236212, in obese children and adolescents.
|
31255630 |
2019 |
|
rs738409
|
|
|
0.900 |
GeneticVariation |
BEFREE |
NAFLD was strongly associated with three genetic variants, TM6SF2 rs58542926, PNPLA3 rs738409 and GCKR rs1260326, and more slightly with ELOVL2 rs2236212, in obese children and adolescents.
|
31255630 |
2019 |
|
rs5854292
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share risk factors, and recent meta-analysis confirmed that NAFLD is an independent risk factor for incident CKD.<sup>1</sup> Genetic variants associated with NAFLD, such as patatin-like phospholipase domain-containing-3 (PNPLA3) rs738409<sup>2</sup> and transmembrane 6 superfamily member 2 (TM6SF2) rs5854292,<sup>2</sup> have been reported to be associated with renal function in NAFLD subjects.
|
31546054 |
2019 |
|
rs11932595
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs11932595 and rs6843722 showed significant associations with NAFLD (empiric P = 0.0449 and 0.023, respectively).
|
17696255 |
2007 |
|
rs1805094
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Lys656Asn polymorphism of LEPR gene is associated with obesity parameters, insulin resistance and glucose levels in patients with NAFLD.
|
22530350 |
2012 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
rs58542926 is a low-frequency variant with a modest effect on NAFLD, suggesting that carriers of the T allele are slightly more likely to accumulate fat in the liver and develop nonalcoholic steatohepatitis than those without.
|
25302781 |
2015 |
|
rs1800562
|
|
|
0.070 |
GeneticVariation |
BEFREE |
C282Y mutation might be a genetic marker of NAFLD</span> in Iranian population.
|
27894410 |
2016 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common non-synonymous polymorphism, E167K, in transmembrane six superfamily member 2 (TM6SF2) gene has been recently associated with an increased hepatic triglyceride content, dyslipidemia and liver fibrosis in NAFLD patients.
|
25581573 |
2015 |
|
rs8192678
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A common polymorphism in this gene (rs8192678, encoding Gly482Ser) has been associated with NAFLD.
|
27658772 |
2017 |
|
rs738409
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A discrete trait analysis of NAFLD showed that rs58542926 was associated with a modest risk of fatty liver (P = 0.038; odds ratio [OR]: 1.37; 95% confidence interval [CI]: 1.02-1.84); nevertheless, conditioning on patatin-like phospholipase domain-containing 3 (PNPLA3)-rs738409 abolished this effect.
|
25302781 |
2015 |
|
rs738409
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A genetic polymorphism in rs738409, in the patatin-like phospholipase domain-containing 3 gene (PNPLA3), is strongly associated with appearance of in NAFLD.
|
25678388 |
2015 |
|
rs738409
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A genetic variant of patatin-like phospholipase domain-containing 3 (PNPLA3-I14</span>8M) is the most prominent heritable factor associated with NAFLD.
|
29286303 |
2017 |
|
rs11235972
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A higher prevalence of rs11235972 GG genotype was observed in the NAFLD group compared with the control group.
|
24124336 |
2013 |
|
rs738409
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A nonsynonymous single nucleotide polymorphism rs738409 (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) predisposes susceptibility to NAFLD; however, its association with steatosis grade is inconsistent in the literature.
|
23176674 |
2012 |
|
rs1799945
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A potential role for H63D mutations in NAFLD pathogenesis is possible through iron-independent mechanisms.
|
22611049 |
2012 |
|
rs738409
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A recent genome-wide association study identified a genetic variant in the patatin-like phospholipase-3 (PNPLA3) gene (rs738409 C>G) associated with steatosis that was further demonstrated to influence severity of fibrosis in nonalcoholic fatty liver disease.
|
21488075 |
2011 |
|
rs2854116
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A recent study in Indian subjects suggested common variants in apolipoprotein C3 (APOC3) (T-455C at rs2854116 and C-482T at rs2854117) to contribute to non-alcoholic fatty liver disease (NAFLD), plasma apoC3 and triglyceride concentrations.
|
22141340 |
2012 |
|
rs2854117
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A recent study in Indian subjects suggested common variants in apolipoprotein C3 (APOC3) (T-455C at rs2854116 and C-482T at rs2854117) to contribute to non-alcoholic fatty liver disease (NAFLD), plasma apoC3 and triglyceride concentrations.
|
22141340 |
2012 |