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rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The TM6SF2 E167K variant was associated with NAFLD in northeast China, and there was an interaction between the PNPLA3 I148M and TMS6F2 E167K variants in NAFLD.
|
31054977 |
2020 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs58542926 polymorphism in TM6SF2 (transmembrane 6 superfamily member 2) is a genetic factor predisposing to nonalcoholic fatty liver disease.
|
31356578 |
2020 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CC genotype of TM6SF2 rs58542926 was associated with a significantly lower risk of NAFLD, while MBOAT7 rs641738 was not related to NAFLD risks.
|
30824369 |
2019 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here, we accessed the seven polymorphisms of rs1260326, rs780094 in GCKR, rs2954021 near TRIB1, rs2228603 in NCAN, rs58542926 in TM6SF2, rs12137855 near LYPLAL1, and rs10883437 near CPN1 on NAFLD susceptibility in the Uygur population.
|
30646922 |
2019 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Metabolic syndrome (MetS) and genetic polymorphisms PNPLA3 rs738409, TM6SF2 rs585</span>42926 and MBOAT7 rs641738 are known inductors of non-alcoholic fatty liver disease (NAFLD).
|
31851849 |
2019 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Importantly, our data indicates that the genetic variant TM6SF2 E167K, previously associated with increased risk for NAFLD, induces increased hepatocyte fat content by reducing APOB particle secretion.
|
31406127 |
2019 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The TM6SF2 rs58542926 T allele promotes the abnormal regulation of lipid profiles and liver injury in NA</span>FLD patients, NAFLD&CRA patients, and overall subjects.
|
30727943 |
2019 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An I148 M variant in patatin-like phospholipase domain-containing protein 3 (PNPLA3) and an E167K variant in transmembrane 6 superfamily 2 (TM6SF2) are major genetic risk factors for the development and progression of NAFLD.
|
30550414 |
2019 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, it was found that a one-portion increase in fish intake increased the risk of NAFLD in carriers of the risk allele of TM6SF2 rs58542926 polymorphism compared to non-carriers, after adjusting for age, gender, energy intake, pack-years, PAL, TM6SF2 genotype and fish consumption (OR<sub>dominant</sub> = 1.503, 95% CI 1.094-2.064).
|
29574608 |
2019 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Combining the I148M and E167K variants in a manner of an additive effect could improve risk prediction for NAFLD in a Qingdao Han Population cohort.
|
30738435 |
2019 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggested that TM6SF2 rs58542926 could be used to identify individuals at higher susceptibility to chronic liver disease, especially for HCC, cirrhosis, ALD, and NAFLD.
|
31309745 |
2019 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
NAFLD was strongly associated with three genetic variants, TM6SF2 rs58542926, PNPLA3 rs738409 and GCKR rs1260326, and more slightly with ELOVL2 rs2236212, in obese children and adolescents.
|
31255630 |
2019 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs738409 single nucleotide polymorphism (SNP) in patatin-like phospholipase domain-containing protein 3 gene and the rs58542926 SNP in transmembrane 6 superfamily member 2 gene have been robustly associated with NAFLD and with its progression, but promising results have been obtained with many other SNPs.
|
30487694 |
2018 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Because PNPLA3 rs738409, GCKR rs780094 and TM6SF2 rs58542926 variants are known to confer susceptibility to NAFLD, we assessed the influence of MBOAT7 rs641738 on hepatic steatosis, and serum levels of CK-18 fragment (a biomarker of hepatocellular injury and apoptosis for NAFLD) after adjusting the effects of PNPLA3, GCKR and TM6SF2 polymorphisms.
|
29314568 |
2018 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among individual variants, rs1260326 in GCKR and rs641738 in MBOAT7 (recessive), rs58542926 in TM6SF2 and rs738409 in PNPLA3 (dominant) emerged as associated to NAFLD, with PNPLA3 rs738409 being the strongest predictor (OR 3.12, 95% CI, 1.8-5.5, P < 0.001).
|
29487372 |
2018 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
As variants in PNPLA3 (I148M) and TM6SF2 (E167K) are associated with nonalcoholic fatty liver disease, we assessed these variants in type 2 diabetes (T2D) patients randomized to receive BIL (n=1822) or GL (n=1270) in three phase 3 trials.
|
29160303 |
2018 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The adiponutrin (PNPLA3) p.I148M and transmembrane 6 superfamily member 2 (TM6SF2) p.E167K variants represent major genetic risk factors for progressive liver injury in nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD) and chronic viral hepatitis.
|
30161167 |
2018 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs738409 and rs58542926 variants, but not rs641738, were associated not only with non-alcoholic steatohepatitis (NASH) (odds ratio [OR], 2.00; 95% confidence interval [CI], 1.46-2.73 and OR, 1.91; 95% CI, 1.04-3.51) but also with significant fibrosis (≥ F2) (OR, 1.53; 95% CI, 1.11-2.11 and OR, 1.88; 95% CI, 1.02-3.46) in NAFLD, even after adjustment for metabolic risk factors.
|
29193269 |
2018 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interestingly, patients harbouring the TM6SF2 rs58542926 T allele that predispose to NAFLD/NASH had higher LBP level.
|
28464257 |
2017 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
TM6SF2 rs58542926 variant affects postprandial lipoprotein metabolism and glucose homeostasis in NAFLD.
|
28242789 |
2017 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study.
|
27836992 |
2017 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no significant difference in the proportions of patients with rs738409 C>G in PNPLA3, but a significantly greater proportion of patients with lean NAFLD carried rs58542926 C>T in TM6SF2 (4%) than obese or overweight individuals with NAFLD (0.3%; P = .001).
|
28554682 |
2017 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here we show that adiposity significantly amplifies the effect of three sequence variants (encoding PNPLA3 p.I148M, TM6SF2 p.E167K, and GCKR p.P446L) associated with nonalcoholic fatty liver disease (NAFLD).
|
28436986 |
2017 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD.
|
28235613 |
2017 |
|
rs58542926
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs58542926 SNP in the TM6SF2 gene is associated with pediatric nonalcoholic fatty liver disease but may confer protection against cardiovascular risk.
|
26457389 |
2016 |