Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs738409
rs738409
0.900 GeneticVariation GWASCAT Genetic Polymorphisms of PNPLA3 and SAMM50 Are Associated with Nonalcoholic Fatty Liver Disease in a Korean Population. 29271184

2018

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE PNPLA3 polymorphisms (rs738409) and non-alcoholic fatty liver disease risk and related phenotypes: a meta-analysis. 25641744

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders. 26765961

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE Here we assess the association of the PNPLA3 variant p.Ile148Met, known to be associated with (non-)alcoholic fatty liver disease (NAFLD) in genome-wide association studies, with cholestatic itch in 187 patients with primary biliary cirrhosis (PBC) and 250 PBC-free controls as well as 201 women with intrahepatic cholestasis of pregnancy (ICP) and 198 female controls without a history of ICP. 25297933

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE The adiponutrin (PNPLA3) p.I148M and transmembrane 6 superfamily member 2 (TM6SF2) p.E167K variants represent risk factors for non-alcoholic fatty liver disease (NAFLD). 26745555

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE The PNPLA3 (adiponutrin) variant p.I148M has been identified as common genetic modifier of NAFLD. 26264356

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE As compared to those with C/C and C/G at rs738409, C/C and C/T at rs3747206, G/G and G/A at rs4823173, and A/A and A/G at rs2072906, patients in the CHB + NAFLD group with G/G at rs738409, T/T at rs3747206, A/A at rs4823173, and G/G at rs2072906 showed significantly lower serum levels of HBV DNA (P < 0.01-0.05). 26229402

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE Genetic variation in both patatin-like phospholipase domain-containing protein-3 (PNPLA3) (I148M) and the transmembrane 6 superfamily member 2 protein (TM6SF2) (E167K) influences severity of liver disease, and serum triglyceride concentrations in non-alcoholic fatty liver disease (NAFLD), but whether either genotype influences the responses to treatments is uncertain. 26272871

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE Besides rs738409 I148M, the rs2294918 G>A polymorphism (E434K sequence variant) was over-represented in NAFLD (adjusted P = 0.01). 26605757

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE A genetic polymorphism in rs738409, in the patatin-like phospholipase domain-containing 3 gene (PNPLA3), is strongly associated with appearance of in NAFLD. 25678388

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE The PNPLA3 rs738409 GG genotype increases susceptibility of NASH in severely obese Asians with NAFLD and correlates to histologic severity of NAFLD. 25240529

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE The Impact of PNPLA3 rs738409 Genetic Polymorphism and Weight Gain ≥10 kg after Age 20 on Non-Alcoholic Fatty Liver Disease in Non-Obese Japanese Individuals. 26485523

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE ADPN I148M polymorphism has been consistently reported to play a role in liver-associated diseases, such as alcoholic liver disease, chronic hepatitis C, and liver fat and fibrosis in nonalcoholic fatty liver disease. 26632699

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE Genetic variation within the PNPLA3 gene (e.g., I148M homozygosity) confers a higher risk of developing more severe histological features of NAFLD, but a lower risk of developing metabolic syndrome traits. 25714786

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE PNPLA3 I148M variant affects non-alcoholic fatty liver disease in liver transplant recipients. 26379412

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing nonalcoholic fatty liver disease. 26148225

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE PNPLA3 rs738409 polymorphism is associated with fatty liver disease, alcoholic or non-alcoholic (NAFLD) and hepatocellular carcinoma (HCC). 26493626

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE Influence of the PNPLA3 rs738409 Polymorphism on Non-Alcoholic Fatty Liver Disease and Renal Function among Normal Weight Subjects. 26200108

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE The PNPLA3 rs738409 G-allele was associated with NAFLD and ALT level in Chinese children. 25522307

2016

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE Genotypes for rs2854116 and rs2854117 in APOC3 and the known rs738409 in patatin-like phospholipase domain-containing protein 3 (PNPLA3) in 390 patients with NAFLD and 409 control subjects were determined by sequencing and polymerase chain reaction analysis. 24707151

2015

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE Here we aimed to investigate the contribution of DNL to liver fat accumulation in the PNPLA3 I148M or TM6SF2 E167K genetic determinants of NAFLD. 25763607

2015

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis. 25624712

2015

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE Role of the PNPLA3 I148M polymorphism in nonalcoholic fatty liver disease and fibrosis in Korea. 25069572

2015

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity. 26136587

2015

dbSNP: rs738409
rs738409
0.900 GeneticVariation BEFREE Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma. 24607626

2015