rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
For PICALM, LOAD association was found only in the APOE ε4 (-) subgroup (rs3851179 adjusted allelic p = 0.028; adjusted genotypic p = 0.013).
|
22015308 |
2012 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia.
|
27023435 |
2017 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD.
|
20554627 |
2010 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD.
|
25189118 |
2015 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In order to evaluate association with these genome-wide association study-identified genes and to isolate the variants contributing to the pathogenesis of LOAD, we genotyped the top single nucleotide polymorphisms (SNPs), rs11136000 (CLU), rs3818361 (CR1), and rs3851179 (PICALM), and sequenced the entire coding regions of these genes in our cohort of 342 LOAD patients and 277 control subjects.
|
22402018 |
2012 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms at the LOAD risk loci CLU (rs11136000), CR1 (rs6656401, rs3818361), and PICALM (rs3851179) were genotyped and tested for association with Logical Memory immediate recall, Logical Memory delayed recall, Logical Memory percent retention, Visual Reproduction immediate recall, Visual Reproduction delayed recall, and Visual Reproduction percent retention scores from the Wechsler Memory Scale-Revised using multivariable linear regression analysis, adjusting for age at exam, sex, education, and apolipoprotein E ε4 dosage.
|
23643458 |
2014 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We also tested for epistatic interaction between these variants and APOE ε4 as well as with the previously replicated LOAD GWAS genes (CLU: rs11136000, CR1: rs3818361, and PICALM: rs3851179).
|
21321396 |
2011 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one variation, rs6656401, in the complement component (3b/4b) receptor 1 (CR) gene were associated with AD.
|
20739100 |
2011 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The effects for all SNPs, except rs3851179, were consistent with those for LOAD risk.
|
24670887 |
2014 |
rs744373
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In summary, we provide additional evidence for the variant near BIN1 (rs744373) as a LOAD risk modifier, but our results indicate that the effect of EXOC3L2 independent of APOE ε4 should be studied further.
|
21321396 |
2011 |
rs744373
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We validated the risk for LOAD with BIN1 (rs744373), CR1 (rs6656401), and ABCA7 (rs376465), as well as the protective association for MS4A6A (rs610932) and CLU (rs11136000) variants.
|
29504051 |
2018 |
rs744373
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To our knowledge, this is the first large meta-analysis to investigate the association between the rs</span>744373 polymorphism and LOAD in East Asian, American, and European populations.
|
26846281 |
2017 |
rs11622883
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A recent study showed two polymorphisms (rs505058 in LMNA and rs11622883 near a SERPINA13 gene), identified in a genome-wide association study of late-onset Alzheimer's disease, to be associated with cognitive function (Mini Mental State Examination) in a UK elderly population.
|
21903150 |
2011 |
rs11622883
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia.
|
27023435 |
2017 |
rs498055
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In a recent scan of single nucleotide polymorphisms (SNPs) on chromosome 10, significant associations between the rs498055 and rs4417206 SNPs and risk of LOAD were observed.
|
17000046 |
2006 |
rs498055
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thus we conclude that rs498055 is not associated with an increased risk of LOAD.
|
17725684 |
2008 |
rs11190302
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When stratifying the sample by APOE one SNP (intergenic SNP rs11190302) was associated with LOAD in individuals lacking the epsilon4 allele (genotypic P = 0.027, allelic P = 0.066).
|
18452187 |
2009 |
rs11613092
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data indicated that 18p11.32 (rs1992269, P = 9.77 × 10(-7)), CNTNAP2 (rs802571, P = 1.26 × 10(-6)), and 12q24.23 (rs11613092, P = 6.85 × 10(-6)) were suggestive loci for susceptibility to LOAD.
|
26049409 |
2015 |
rs12570088
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of these, rs2516049 (closest gene HLA-DRB5; conjunction false discovery rate P = .04 for AD and psoriasis, 5.37 × 10-5 for AD, and 6.03 × 10-15 for psoriasis) and rs12570088 (closest gene IPMK; conjunction false discovery rate P = .009 for AD and Crohn disease, P = 5.73 × 10-6 for AD, and 6.57 × 10-5 for Crohn disease) demonstrated the same direction of allelic effect between AD and the immune-mediated diseases.
|
27088644 |
2016 |
rs1992269
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data indicated that 18p11.32 (rs1992269, P = 9.77 × 10(-7)), CNTNAP2 (rs802571, P = 1.26 × 10(-6)), and 12q24.23 (rs11613092, P = 6.85 × 10(-6)) were suggestive loci for susceptibility to LOAD.
|
26049409 |
2015 |
rs2279420
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated nominally significant association with LOAD for 4 SNPs: rs1881747 near DKK1 (P = 0.011, OR = 1.24), rs2279420 in ANK3 (P = 0.022, OR = 0.79), rs2306402 in CTNNA3 (P = 0.024, OR = 1.18), and rs5030882 in CXXC6 (P = 0.046, OR = 1.29) in 1,160 cases and 1,389 controls.
|
18163421 |
2008 |
rs2927438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Importantly, rs2927438 may represent an APOE-independent LOAD eSNP according to the weak linkage disequilibrium of rs2927438 with the 2 polymorphisms (rs7412 and rs429358) defining the APOE-ε2, -ε3, and -ε4 alleles.
|
29395286 |
2018 |
rs376465
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We validated the risk for LOAD with BIN1 (rs744373), CR1 (rs6656401), and ABCA7 (rs376465), as well as the protective association for MS4A6A (rs610932) and CLU (rs11136000) variants.
|
29504051 |
2018 |
rs541458
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The PICALM rs541458 T allele has been recognized as a risk factor for late-onset Alzheimer's disease, and age might modulate the effects that genetic factors have on cognitive functions and brain.
|
28116548 |
2018 |
rs7294919
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism rs7294919 on chromosome 12q24.22 is associated with late-onset Alzheimer's disease in Han Chinese.
|
24361131 |
2014 |