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rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A variable-length poly-T variant in intron 6 of the TOMM40 gene, rs10524523, is associated with risk and age-of-onset of sporadic (late-onset) Alzheimer's disease.
|
28768149 |
2017 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The very long (VL) poly-T variant at rs10524523 ("523") of the TOMM40 gene may hasten the onset of late-onset Alzheimer's disease (LOAD) and induce more profound cognitive impairment compared with the short (S) poly-T variant.
|
25862420 |
2015 |
|
rs75932628
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Here, we present more evidence for the association of the R47H with LOAD risk in a Caucasian population comprising 4567 LOAD cases and controls.
|
26058841 |
2015 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We conclude that the poly-T repeat associations of rs10524523 in TOMM40 reflect the APOE ε4-dependent association in LOAD.
|
25500937 |
2014 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We investigated the genomic region spanning the Translocase of the Outer Mitochondrial Membrane 40-kD (TOMM40) and Apolipoprotein E (APOE) genes, that has been associated with the risk and age of onset of late-onset Alzheimer's disease (LOAD) to determine whether a highly polymorphic, intronic poly-T within this region (rs10524523; hereafter, 523) affects expression of the APOE and TOMM40 genes.
|
24439168 |
2014 |
|
rs75932628
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Association study of TREM2 polymorphism rs75932628 with late-onset Alzheimer's disease in Chinese Han population.
|
24725293 |
2014 |
|
rs75932628
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Only the rs75932628-T variant (predicted to cause an R47H substitution) conferred a significant risk for early-onset AD (OR, 4.07; 95% CI, 1.3 to 16.9; p = 0.009).
|
23380991 |
2013 |
|
rs75932628
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Recent works have demonstrated a rare functional variant (R47H) in triggering receptor expressed on myeloid cells (TREM) 2 gene, encoding TREM2 protein, increase susceptibility to late-onset Alzheimer's disease (AD), with an odds ratio similar to that of the apolipoprotein E ε4 allele.
|
23407992 |
2013 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We conclude that in the carriers of TOMM40-APOE haplotypes comprising E4 allele, the TOMM40 rs10524523 allele does not play substantial role in establishing LOAD risk.
|
22008263 |
2012 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A variable poly-T length polymorphism at rs10524523, within intron 6 of the translocase of the outer mitochondrial membrane (TOMM40) gene, has been shown to influence age of onset in LOAD, with very long (VL) poly-T length associated with earlier disease onset, and short poly-T length associated with later onset.
|
21784354 |
2011 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We found a significant association between rs10524523 and risk of LOAD in APOE 33 homozygotes but in the opposite direction as the previously reported association (the very long allele was underrepresented in cases vs controls in this study (P = .004]).
|
21825236 |
2011 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In two independent clinical cohorts, longer lengths of rs10524523 are associated with a higher risk for LOAD.
|
20029386 |
2010 |
|
rs6656401
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We validated the risk for LOAD with BIN1 (rs744373), CR1 (rs6656401), and ABCA7 (rs376465), as well as the protective association for MS4A6A (rs610932) and CLU (rs11136000) variants.
|
29504051 |
2018 |
|
rs6656401
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Thus, the present work aimed to assess the involvement of CD33 (rs3865444), ABCA7 (rs3764650), CR1 (rs6656401), and MS4A6A (rs610932) with LOAD in a sample from southeastern Brazil.
|
28477215 |
2017 |
|
rs6656401
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Finally, we found rs6656401-rs3865444 (CR1-CD33) pairs were significantly associated with decreasing LOAD risk, while rs28834970-rs6656401 (PTK2B-CR1), and rs28834970-rs6656401 (PTK2B-CD33) were associated with increasing LOAD risk.
|
26680604 |
2015 |
|
rs6656401
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Overall, the pooled data showed that the CR1 rs6656401 polymorphism was significantly associated with LOAD risk in the overall population (A vs. G: OR=1.32, 95%CI=1.17-1.50, P=0.000; AG+AA vs. GG: OR=1.39, 95%CI=1.20-1.61, P=0.000).
|
24996192 |
2014 |
|
rs6656401
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In addition, carriers of the A allele (AA+AG) of rs6656401 had a 1.69-fold increased risk for LOAD compared with non-carriers (GG) (P=0.01).
|
22960360 |
2012 |
|
rs6656401
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We found by multivariate logistic regression analysis, that single nucleotide polymorphisms (SNPs) in CR1 (rs6656401 adjusted allelic p = 0.035; adjusted genotypic p = 0.043) and CLU (rs2279590 adjusted allelic p = 0.035; adjusted genotypic p = 0.006; rs11136000 adjusted allelic p = 0.038; adjusted genotypic p = 0.009) were significantly different between LOAD patients and nondemented controls.
|
22015308 |
2012 |
|
rs6656401
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one variation, rs6656401, in the complement component (3b/4b) receptor 1 (CR) gene were associated with AD.
|
20739100 |
2011 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Low folate intake and genetic variants in folate metabolism, such as the methylenetetrahydrofolate reductase (MTHFR) 677 C>T polymorphism, have been suggested to impact brain function and increase the risk for cognitive decline and late-onset Alzheimer's disease.
|
30288696 |
2019 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We found that a substantial link exists between C677T polymorphism and LOAD risk in a codominant framework (TC vs. CC: OR=1.22, 95%CI=1.00-1.49, P=0.049).
|
30631824 |
2019 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The present results suggest that the MTHFR C677T polymorphism is likely a LOAD risk factor in our cohort, either in APOEɛ4 or in non-APOEɛ4 carriers.
|
28211809 |
2017 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We screened 378 late-onset Alzheimer's disease (LOAD) patients and 308 matched controls for the presence of the common MTHFR 677C>T, MTRR 66A>G, MTR 2756 A>G, and TYMS 28 bp repeat polymorphisms, searching for association with disease risk and age at onset.
|
22034983 |
2012 |
|
rs2986017
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A recent paper reported that a variant (rs2986017) of the calcium homeostasis modulator 1 (CALHM1) gene affects risk for late-onset Alzheimer's disease (AD).
|
20164573 |
2010 |
|
rs2986017
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Lack of implication for CALHM1 P86L common variation in Italian patients with early and late onset Alzheimer's disease.
|
20164602 |
2010 |