Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.080 | GeneticVariation | BEFREE | Our findings suggest that the rs75932628-T variant of TREM2 is an important risk factor for LOAD in the Colombian population. | 30222607 | 2019 |
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0.080 | GeneticVariation | BEFREE | We did not find an association between the rs75932628</span> single nucleotide polymorphism of TREM2 and LOAD in this study. | 29256968 | 2018 |
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0.080 | GeneticVariation | BEFREE | The R47H TREM2 variant is a significant risk factor for late-onset Alzheimer's disease (AD), and the molecular basis of R47H TREM2 loss of function is an emerging area of TREM2 biology. | 29794134 | 2018 |
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0.080 | GeneticVariation | BEFREE | The R47H variant of the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) significantly increases the risk for late onset Alzheimer's disease. | 30185230 | 2018 |
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0.080 | GeneticVariation | BEFREE | Here, we present more evidence for the association of the R47H with LOAD risk in a Caucasian population comprising 4567 LOAD cases and controls. | 26058841 | 2015 |
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0.080 | GeneticVariation | BEFREE | Association study of TREM2 polymorphism rs75932628 with late-onset Alzheimer's disease in Chinese Han population. | 24725293 | 2014 |
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0.080 | GeneticVariation | BEFREE | Only the rs75932628-T variant (predicted to cause an R47H substitution) conferred a significant risk for early-onset AD (OR, 4.07; 95% CI, 1.3 to 16.9; p = 0.009). | 23380991 | 2013 |
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0.080 | GeneticVariation | BEFREE | Recent works have demonstrated a rare functional variant (R47H) in triggering receptor expressed on myeloid cells (TREM) 2 gene, encoding TREM2 protein, increase susceptibility to late-onset Alzheimer's disease (AD), with an odds ratio similar to that of the apolipoprotein E ε4 allele. | 23407992 | 2013 |