|
rs429358
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Predictability models for LOAD were developed incorporating the PRS with APOE SNPs (rs7412 and rs429358), age and gender.
|
31127079 |
2019 |
|
rs429358
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Importantly, rs2927438 may represent an APOE-independent LOAD eSNP according to the weak linkage disequilibrium of rs2927438 with the 2 polymorphisms (rs7412 and rs429358) defining the APOE-ε2, -ε3, and -ε4 alleles.
|
29395286 |
2018 |
|
rs429358
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Two common single-nucleotide polymorphisms (SNPs) in APOE, rs429358 and rs7412, determine the three epsilon alleles that are established genetic risk factors for late-onset Alzheimer's disease (AD), cerebral amyloid angiopathy, and intracerebral hemorrhage (ICH).
|
24448547 |
2014 |
|
rs429358
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A significant association was observed between late-onset Alzheimer's disease and the epsilon 4 (112Cys-->Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII.
|
8024269 |
1994 |
|
rs7412
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Predictability models for LOAD were developed incorporating the PRS with APOE SNPs (rs7412 and rs429358), age and gender.
|
31127079 |
2019 |
|
rs7412
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Importantly, rs2927438 may represent an APOE-independent LOAD eSNP according to the weak linkage disequilibrium of rs2927438 with the 2 polymorphisms (rs7412 and rs429358) defining the APOE-ε2, -ε3, and -ε4 alleles.
|
29395286 |
2018 |
|
rs7412
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Two common single-nucleotide polymorphisms (SNPs) in APOE, rs429358 and rs7412, determine the three epsilon alleles that are established genetic risk factors for late-onset Alzheimer's disease (AD), cerebral amyloid angiopathy, and intracerebral hemorrhage (ICH).
|
24448547 |
2014 |
|
rs764929617
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We propose that these structural and functional changes underlie the observed added risk for AD development in carriers of apoE4[L28P].
|
24644280 |
2014 |
|
rs764929617
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The minor allele of p.L28P, which was in complete linkage disequilibrium (D' = 1) with the far more common APOE ϵ4 allele, showed no association with LOAD (P = 0.75) independent of the APOE ϵ4 allele. p.V236E was significantly associated with a marked reduction in risk of LOAD (P = 7.5 × 10⁻⁰⁵; OR = 0.10, 0.03 to 0.45).
|
24607147 |
2014 |
|
rs764929617
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Compared to E3/3 and E3/2 genotypes, the risk of developing AD associated with the genotypes carrying the e(*)4 allele, the well-established risk allele for AD onset, was observed to be high (OR=3.16; 95% CI=1.62-6.20; P=0.0009), but the risk associated with genotypes carrying the Leu28-->Pro mutation was higher still (OR=10.95; 95% CI=1.25-95.75; P=0.015).
|
12498968 |
2003 |
|
rs387906567
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We finally identified a rare nonsynonymous variant, rs572750141 (NM_030974.3:p.Gly186Arg), in SHARPIN that was potentially associated with increased risk of LOAD (corrected P = 8.05 × 10<sup>- 5</sup>, odds ratio = 6.1).
|
31216982 |
2019 |
|
rs405509
|
|
|
0.010 |
GeneticVariation |
BEFREE |
G allele of the rs405509 of APOE and G allele of the rs1805192 of PPAR G polymorphism were associated with increased LOAD risk, and participants with AG or GG of rs405509 and CG or GG of rs1805192 genotype have the highest AD risk.
|
28346566 |
2017 |
|
rs199768005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele of p.L28P, which was in complete linkage disequilibrium (D' = 1) with the far more common APOE ϵ4 allele, showed no association with LOAD (P = 0.75) independent of the APOE ϵ4 allele. p.V236E was significantly associated with a marked reduction in risk of LOAD (P = 7.5 × 10⁻⁰⁵; OR = 0.10, 0.03 to 0.45).
|
24607147 |
2014 |