Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1925690
rs1925690
0.700 GeneticVariation GWASDB Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. 21116278

2012

dbSNP: rs749005
rs749005
0.700 GeneticVariation GWASDB Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. 21116278

2012

dbSNP: rs11136000
rs11136000
CLU
0.090 GeneticVariation BEFREE CLU-rs11136000-G associated with worse baseline memory and incident MCI/LOAD. 25189118

2015

dbSNP: rs11136000
rs11136000
CLU
0.090 GeneticVariation BEFREE The C allele at the rs11136000 locus in the clusterin (CLU) gene is the third strongest known genetic risk factor for late-onset Alzheimer's disease (LOAD). 24806679

2014

dbSNP: rs11136000
rs11136000
CLU
0.090 GeneticVariation BEFREE Single nucleotide polymorphisms at the LOAD risk loci CLU (rs11136000), CR1 (rs6656401, rs3818361), and PICALM (rs3851179) were genotyped and tested for association with Logical Memory immediate recall, Logical Memory delayed recall, Logical Memory percent retention, Visual Reproduction immediate recall, Visual Reproduction delayed recall, and Visual Reproduction percent retention scores from the Wechsler Memory Scale-Revised using multivariable linear regression analysis, adjusting for age at exam, sex, education, and apolipoprotein E ε4 dosage. 23643458

2014

dbSNP: rs11136000
rs11136000
CLU
0.090 GeneticVariation BEFREE We found by multivariate logistic regression analysis, that single nucleotide polymorphisms (SNPs) in CR1 (rs6656401 adjusted allelic p = 0.035; adjusted genotypic p = 0.043) and CLU (rs2279590 adjusted allelic p = 0.035; adjusted genotypic p = 0.006; rs11136000 adjusted allelic p = 0.038; adjusted genotypic p = 0.009) were significantly different between LOAD patients and nondemented controls. 22015308

2012

dbSNP: rs11136000
rs11136000
CLU
0.090 GeneticVariation BEFREE We also tested for epistatic interaction between these variants and APOE ε4 as well as with the previously replicated LOAD GWAS genes (CLU: rs11136000, CR1: rs3818361, and PICALM: rs3851179). 21321396

2012

dbSNP: rs11136000
rs11136000
CLU
0.090 GeneticVariation BEFREE In order to evaluate association with these genome-wide association study-identified genes and to isolate the variants contributing to the pathogenesis of LOAD, we genotyped the top single nucleotide polymorphisms (SNPs), rs11136000 (CLU), rs3818361 (CR1), and rs3851179 (PICALM), and sequenced the entire coding regions of these genes in our cohort of 342 LOAD patients and 277 control subjects. 22402018

2012

dbSNP: rs11136000
rs11136000
CLU
0.090 GeneticVariation BEFREE Recently, two large, and independent genome wide association studies of late-onset Alzheimer's disease (AD) established association with the same rs11136000 variation in the clusterin (CLU) gene. 20739100

2011

dbSNP: rs11136000
rs11136000
CLU
0.090 GeneticVariation BEFREE There was evidence of association for recently-reported LOAD risk loci, including BIN1 (rs7561528, p = 0.009 with, and p = 0.03 without, APOE adjustment) and CLU (rs11136000, p = 0.023 with, and p = 0.008 without, APOE adjustment), with weaker support for CR1. 21379329

2011

dbSNP: rs11136000
rs11136000
CLU
0.090 GeneticVariation BEFREE The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD. 20554627

2010

dbSNP: rs3851179
rs3851179
0.080 GeneticVariation BEFREE PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD. 25189118

2015

dbSNP: rs3851179
rs3851179
0.080 GeneticVariation BEFREE The effects for all SNPs, except rs3851179, were consistent with those for LOAD risk. 24670887

2014

dbSNP: rs3851179
rs3851179
0.080 GeneticVariation BEFREE Single nucleotide polymorphisms at the LOAD risk loci CLU (rs11136000), CR1 (rs6656401, rs3818361), and PICALM (rs3851179) were genotyped and tested for association with Logical Memory immediate recall, Logical Memory delayed recall, Logical Memory percent retention, Visual Reproduction immediate recall, Visual Reproduction delayed recall, and Visual Reproduction percent retention scores from the Wechsler Memory Scale-Revised using multivariable linear regression analysis, adjusting for age at exam, sex, education, and apolipoprotein E ε4 dosage. 23643458

2014

dbSNP: rs3851179
rs3851179
0.080 GeneticVariation BEFREE For PICALM, LOAD association was found only in the APOE ε4 (-) subgroup (rs3851179 adjusted allelic p = 0.028; adjusted genotypic p = 0.013). 22015308

2012

dbSNP: rs3851179
rs3851179
0.080 GeneticVariation BEFREE In order to evaluate association with these genome-wide association study-identified genes and to isolate the variants contributing to the pathogenesis of LOAD, we genotyped the top single nucleotide polymorphisms (SNPs), rs11136000 (CLU), rs3818361 (CR1), and rs3851179 (PICALM), and sequenced the entire coding regions of these genes in our cohort of 342 LOAD patients and 277 control subjects. 22402018

2012

dbSNP: rs3851179
rs3851179
0.080 GeneticVariation BEFREE We also tested for epistatic interaction between these variants and APOE ε4 as well as with the previously replicated LOAD GWAS genes (CLU: rs11136000, CR1: rs3818361, and PICALM: rs3851179). 21321396

2012

dbSNP: rs3851179
rs3851179
0.080 GeneticVariation BEFREE In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one variation, rs6656401, in the complement component (3b/4b) receptor 1 (CR) gene were associated with AD. 20739100

2011

dbSNP: rs3851179
rs3851179
0.080 GeneticVariation BEFREE The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD. 20554627

2010

dbSNP: rs10524523
rs10524523
0.070 GeneticVariation BEFREE We investigated the genomic region spanning the Translocase of the Outer Mitochondrial Membrane 40-kD (TOMM40) and Apolipoprotein E (APOE) genes, that has been associated with the risk and age of onset of late-onset Alzheimer's disease (LOAD) to determine whether a highly polymorphic, intronic poly-T within this region (rs10524523; hereafter, 523) affects expression of the APOE and TOMM40 genes. 24439168

2016

dbSNP: rs10524523
rs10524523
0.070 GeneticVariation BEFREE The very long (VL) poly-T variant at rs10524523 ("523") of the TOMM40 gene may hasten the onset of late-onset Alzheimer's disease (LOAD) and induce more profound cognitive impairment compared with the short (S) poly-T variant. 25862420

2016

dbSNP: rs10524523
rs10524523
0.070 GeneticVariation BEFREE We conclude that the poly-T repeat associations of rs10524523 in TOMM40 reflect the APOE ε4-dependent association in LOAD. 25500937

2015

dbSNP: rs10524523
rs10524523
0.070 GeneticVariation BEFREE TOMM40 rs10524523 polymorphism's role in late-onset Alzheimer's disease and in longevity. 22008263

2012

dbSNP: rs10524523
rs10524523
0.070 GeneticVariation BEFREE We found a significant association between rs10524523 and risk of LOAD in APOE 33 homozygotes but in the opposite direction as the previously reported association (the very long allele was underrepresented in cases vs controls in this study (P = .004]). 21825236

2011

dbSNP: rs10524523
rs10524523
0.070 GeneticVariation BEFREE A variable poly-T length polymorphism at rs10524523, within intron 6 of the translocase of the outer mitochondrial membrane (TOMM40) gene, has been shown to influence age of onset in LOAD, with very long (VL) poly-T length associated with earlier disease onset, and short poly-T length associated with later onset. 21784354

2011