|
rs1801474
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In particular, patients with A allele of Ser167Asn have risk of having high serum iron concentration (OR 11.55, 95% CI 5.59-23.85), which are associated with dementia and postural imbalance.
|
31512170 |
2020 |
|
rs748703149
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a whole-exome sequencing study of a family with probable AD-type dementia without pathogenic variants in known autosomal dominant dementia disease genes and negative for the apolipoprotein E (APOE) ε4 allele, we identified an extremely rare TREM2 coding variant, that is, a glycine-to-tryptophan substitution at amino acid position 145 (NM_018965.3:c.433G>T/p.[Gly145Trp]).
|
31464095 |
2020 |
|
rs766647311
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results, suggest that a p.(Gly145Trp)-induced structural disturbance and functional impairment of TREM2 may contribute to the pathogenesis of an AD-like form of dementia.
|
31464095 |
2020 |
|
rs766647311
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a whole-exome sequencing study of a family with probable AD-type dementia without pathogenic variants in known autosomal dominant dementia disease genes and negative for the apolipoprotein E (APOE) ε4 allele, we identified an extremely rare TREM2 coding variant, that is, a glycine-to-tryptophan substitution at amino acid position 145 (NM_018965.3:c.433G>T/p.[Gly145Trp]).
|
31464095 |
2020 |
|
rs11931074
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PD patients carrying the protective GG genotype at SNCA rs11931074 may be at significantly higher risk of dementia than patients with other genotypes.
|
31102707 |
2019 |
|
rs1416580204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, an association was investigated in Turkish cohorts of patients with dementia with Alzheimer's Type (DAT) and MCI patients by measuring serum sRAGE levels and by genotyping G82S polymorphism and comparing them to healthy control (HC) subjects.
|
30389362 |
2019 |
|
rs17125721
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe a large Italian family, which we followed from January 2003 to January 2018, with the late-onset AD and the E318G variant, with the aim of assessing E318G-associated CSF or plasma biochemical changes in biomarkers of dementia.
|
30381075 |
2019 |
|
rs17518584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We aimed to validate this finding in our sample of 944 cognitively normal Jewish elderly individuals with type 2 diabetes (T2D), a population which is at risk for cognitive decline and dementia.<b>Methods:</b> Using linear regression, we studied the association of rs17518584 with DSST performance, adjusting for demographic, T2D-related characteristics and cardiovascular factors.
|
28797215 |
2019 |
|
rs2070600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, an association was investigated in Turkish cohorts of patients with dementia with Alzheimer's Type (DAT) and MCI patients by measuring serum sRAGE levels and by genotyping G82S polymorphism and comparing them to healthy control (HC) subjects.
|
30389362 |
2019 |
|
rs242557
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The microtubule-associated protein tau gene (<i>MAPT</i>) rs242557 variant is associated with multiple tauopathies and dementia.
|
30708351 |
2019 |
|
rs334558
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Notably, another promotor SNP (rs334558) of the GSK-3β gene is reportedly associated with unipolar depression, bipolar disorders, and dementia.
|
31742842 |
2019 |
|
rs3764435
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here for the first time, we show an association between PD and rs3764435 in a Mexican mestizo population, suggesting it confers neuroprotection for dementia in PD and is neuroprotective against developing PD in the males of this population.
|
31649613 |
2019 |
|
rs3764650
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, in African Americans the interactive effects of ABCA7 rs3764650 and aerobic fitness likely compound overall ABCA7-related AD risk, and may contribute to health disparities whereby African Americans are at a higher risk for dementia, with double the prevalence of AD.
|
31024289 |
2019 |
|
rs405509
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The number of minor alleles in rs405509</span> or rs440446 was not associated with dementia risk (hazard ratios<1.43; 95% CI 0.87, 2.36).
|
30293724 |
2019 |
|
rs440446
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The number of minor alleles in rs405509 or rs</span>440446 was not associated with dementia risk (hazard ratios<1.43; 95% CI 0.87, 2.36).
|
30293724 |
2019 |
|
rs63750083
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report a 35 year-old male with childhood learning disability and early onset dementia who is homozygous for the A431E variant in the PSEN1 gene.
|
30716424 |
2019 |
|
rs9357347
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Methods:</b> This study analyzed the association of rs9357347 with AD-related cerebrospinal fluid (CSF) and neuroimaging markers from 201 cognitively normal (CN) older adults, 349 elders with mild cognitive impairment (MCI), and 172 elders with AD dementia from the Alzheimer's Disease Neuroimaging Initiative (ADNI).
|
31379492 |
2019 |
|
rs2276109
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2276109 and rs652438 allele and genotype frequencies were not associated with dementia in PD patients.
|
28655442 |
2018 |
|
rs2298813
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A528T was tested for association with PD risk, the development of dementia, and in a subset of patients (n = 103) for associations with established AD cerebrospinal fluid (CSF) biomarkers measured at the time of PD diagnosis.
|
29567423 |
2018 |
|
rs652438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2276109 and rs652438 allele and genotype frequencies were not associated with dementia in PD patients.
|
28655442 |
2018 |
|
rs763841075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
They describe two fraternal twins carrying the missense GRN Cys139Arg mutation affected by late-onset dementia and we report the neuropathological study of one of them.
|
27997711 |
2018 |
|
rs767425642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association between dementia risk and all the studied polymorphisms except of PON1-Q192R was found to be significant.
|
28657841 |
2018 |
|
rs854560
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that, ApoE ε4, ACE I and PON1-L55M T alleles are associated with dementia risk whether these polymorphisms were studied separately or gathered in haplotypes.
|
28657841 |
2018 |
|
rs9331896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no interaction between rs9331896 in CLU and rs429358 (defining the ɛ4 allele) in APOE in predicting Alzheimer's disease or all dementia (P = 0.39 and P = 0.21).
|
29534716 |
2018 |
|
rs950530102
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither allelic nor genotypic BDNF Val66Met SNP was associated with dementia or with BP (associated or not with clinical manifestation of dementia).
|
30220011 |
2018 |