Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2230288
rs2230288
GBA
0.720 GeneticVariation BEFREE Mutation carriers (n = 60; 4.4%) and E326K carriers (n = 65; 4.7%) had a higher prevalence of dementia (mutations, odds ratio = 5.1; P = 9.7 × 10(-6) ; E326K, odds ratio = 6.4; P = 5.7 × 10(-7) ) and lower performance on Letter-Number Sequencing (mutations, corrected P[Pc ] = 9.0 × 10(-4) ; E326K, Pc  = 0.036), Trail Making B-A (mutations, Pc  = 0.018; E326K, Pc  = 0.018), and Benton Judgment of Line Orientation (mutations, Pc  = 0.0045; E326K, Pc  = 0.0013). 26296077

2016

dbSNP: rs2230288
rs2230288
GBA
0.720 GeneticVariation BEFREE A significantly higher proportion of E326K carriers (10 of 21 [47.6%]; P = .01) and GBA variant carriers (15 of 39 [38.5%]; P = .04) progressed to mild cognitive impairment or dementia. 27571329

2016

dbSNP: rs2230288
rs2230288
GBA
T 0.720 SusceptibilityMutation CLINVAR

dbSNP: rs12604324
rs12604324
A 0.700 GeneticVariation GWASCAT Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. 25188341

2014

dbSNP: rs1741309
rs1741309
A 0.700 GeneticVariation GWASCAT Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. 25188341

2014

dbSNP: rs41526548
rs41526548
C 0.700 GeneticVariation GWASCAT Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. 25188341

2014

dbSNP: rs6857
rs6857
T 0.700 GeneticVariation GWASCAT Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. 25188341

2014

dbSNP: rs1057518919
rs1057518919
G 0.700 CausalMutation CLINVAR

dbSNP: rs1345176461
rs1345176461
A 0.700 GeneticVariation CLINVAR

dbSNP: rs137852959
rs137852959
A 0.700 CausalMutation CLINVAR

dbSNP: rs148881970
rs148881970
G 0.700 CausalMutation CLINVAR

dbSNP: rs555145190
rs555145190
T 0.700 CausalMutation CLINVAR

dbSNP: rs63750301
rs63750301
T 0.700 GeneticVariation CLINVAR

dbSNP: rs63751011
rs63751011
T 0.700 CausalMutation CLINVAR

dbSNP: rs6265
rs6265
0.060 GeneticVariation BEFREE A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers. 30775992

2019

dbSNP: rs759834365
rs759834365
0.060 GeneticVariation BEFREE A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers. 30775992

2019

dbSNP: rs6265
rs6265
0.060 GeneticVariation BEFREE Neither allelic nor genotypic BDNF Val66Met SNP was associated with dementia or with BP (associated or not with clinical manifestation of dementia). 30220011

2018

dbSNP: rs759834365
rs759834365
0.060 GeneticVariation BEFREE Neither allelic nor genotypic BDNF Val66Met SNP was associated with dementia or with BP (associated or not with clinical manifestation of dementia). 30220011

2018

dbSNP: rs6265
rs6265
0.060 GeneticVariation BEFREE Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and post-stroke dementia: a hospital-based study from northern Iran. 27071687

2016

dbSNP: rs759834365
rs759834365
0.060 GeneticVariation BEFREE Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and post-stroke dementia: a hospital-based study from northern Iran. 27071687

2016

dbSNP: rs6265
rs6265
0.060 GeneticVariation BEFREE Effect of BDNF Val66Met polymorphism on regional white matter hyperintensities and cognitive function in elderly males without dementia. 24275008

2014

dbSNP: rs759834365
rs759834365
0.060 GeneticVariation BEFREE Effect of BDNF Val66Met polymorphism on regional white matter hyperintensities and cognitive function in elderly males without dementia. 24275008

2014

dbSNP: rs6265
rs6265
0.060 GeneticVariation BEFREE Among 200 outpatients with dementia and MCI, 146 outpatients with mild AD or A-MCI were recruited and divided into two genotypic groups, valine homozygosity (Val/Val) and methionine (Met) carriers, based on the representative BDNF functional polymorphism Val66Met. 22699449

2012

dbSNP: rs759834365
rs759834365
0.060 GeneticVariation BEFREE Among 200 outpatients with dementia and MCI, 146 outpatients with mild AD or A-MCI were recruited and divided into two genotypic groups, valine homozygosity (Val/Val) and methionine (Met) carriers, based on the representative BDNF functional polymorphism Val66Met. 22699449

2012

dbSNP: rs6265
rs6265
0.060 GeneticVariation BEFREE Role of BDNF val66met polymorphism on the association between physical activity and incident dementia. 20172629

2011