rs2230288
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Mutation carriers (n = 60; 4.4%) and E326K carriers (n = 65; 4.7%) had a higher prevalence of dementia (mutations, odds ratio = 5.1; P = 9.7 × 10(-6) ; E326K, odds ratio = 6.4; P = 5.7 × 10(-7) ) and lower performance on Letter-Number Sequencing (mutations, corrected P[Pc ] = 9.0 × 10(-4) ; E326K, Pc = 0.036), Trail Making B-A (mutations, Pc = 0.018; E326K, Pc = 0.018), and Benton Judgment of Line Orientation (mutations, Pc = 0.0045; E326K, Pc = 0.0013).
|
26296077 |
2016 |
rs2230288
|
|
|
0.720 |
GeneticVariation |
BEFREE |
A significantly higher proportion of E326K carriers (10 of 21 [47.6%]; P = .01) and GBA variant carriers (15 of 39 [38.5%]; P = .04) progressed to mild cognitive impairment or dementia.
|
27571329 |
2016 |
rs2230288
|
|
T |
0.720 |
SusceptibilityMutation |
CLINVAR |
|
|
|
rs12604324
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.
|
25188341 |
2014 |
rs1741309
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.
|
25188341 |
2014 |
rs41526548
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.
|
25188341 |
2014 |
rs6857
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.
|
25188341 |
2014 |
rs1057518919
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1345176461
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs137852959
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs148881970
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs555145190
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs63750301
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs63751011
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs6265
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers.
|
30775992 |
2019 |
rs759834365
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers.
|
30775992 |
2019 |
rs6265
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Neither allelic nor genotypic BDNF Val66Met SNP was associated with dementia or with BP (associated or not with clinical manifestation of dementia).
|
30220011 |
2018 |
rs759834365
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Neither allelic nor genotypic BDNF Val66Met SNP was associated with dementia or with BP (associated or not with clinical manifestation of dementia).
|
30220011 |
2018 |
rs6265
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and post-stroke dementia: a hospital-based study from northern Iran.
|
27071687 |
2016 |
rs759834365
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and post-stroke dementia: a hospital-based study from northern Iran.
|
27071687 |
2016 |
rs6265
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Effect of BDNF Val66Met polymorphism on regional white matter hyperintensities and cognitive function in elderly males without dementia.
|
24275008 |
2014 |
rs759834365
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Effect of BDNF Val66Met polymorphism on regional white matter hyperintensities and cognitive function in elderly males without dementia.
|
24275008 |
2014 |
rs6265
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Among 200 outpatients with dementia and MCI, 146 outpatients with mild AD or A-MCI were recruited and divided into two genotypic groups, valine homozygosity (Val/Val) and methionine (Met) carriers, based on the representative BDNF functional polymorphism Val66Met.
|
22699449 |
2012 |
rs759834365
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Among 200 outpatients with dementia and MCI, 146 outpatients with mild AD or A-MCI were recruited and divided into two genotypic groups, valine homozygosity (Val/Val) and methionine (Met) carriers, based on the representative BDNF functional polymorphism Val66Met.
|
22699449 |
2012 |
rs6265
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Role of BDNF val66met polymorphism on the association between physical activity and incident dementia.
|
20172629 |
2011 |