Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121912438
rs121912438
SOD1
0.050 GeneticVariation BEFREE Recently a tissue-specific and selective upregulation of the multidrug efflux transporter ABCB1 or P-glycoprotein (P-gp) in the spinal cord of both patients and the mutant SOD1-G93A mouse model of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease that prevalently kills motor neurons has been reported. 27158936

2016
dbSNP: rs121912438
rs121912438
SOD1
0.050 GeneticVariation BEFREE We used SOD1(G93A) mice as a model, which exhibit the motor neuron-specific neurodegenerative disease, amyotrophic lateral sclerosis. 23470532

2013
dbSNP: rs121912438
rs121912438
SOD1
0.050 GeneticVariation BEFREE We then analyzed molecular changes in microglia during neurodegenerative disease activation using the SOD1(G93A) mouse model of amyotrophic lateral sclerosis (ALS). 23850290

2013
dbSNP: rs121912438
rs121912438
SOD1
0.050 GeneticVariation BEFREE Transgenic mice carrying the G93A mutation of the superoxide dismutase 1 (SOD1) gene develop a neurodegenerative disease closely mimicking human ALS. 20450936

2010
dbSNP: rs121912438
rs121912438
SOD1
0.050 GeneticVariation BEFREE These results show that in the SOD1(G93A) model of neurodegenerative diseases, the concentration of brain glutamate (determined with (1)H-MRS) can be lowered by inhibiting in vivo the synthesis of glutamine with non-toxic doses of MSO. 20060132

2010