|
rs2230912
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The Gln460Arg (rs2230912) polymorphism of the P2RX7 gene has been widely studied in mood disorders, however the results are still controversial.
|
30664971 |
2019 |
|
rs2230912
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The Gln460Arg (rs2230912) polymorphism of the P2RX7 gene has been widely studied in mood disorders, however the results are still controversial.
|
30664971 |
2019 |
|
rs2230912
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We found a significant association between rs2230912 and combined mood disorders (major depressive disorder (MDD) or bipolar disorder (BD)) for the allelic, dominant and heterozygous-disadvantage model, all withstanding the threshold of correction for multiple testing.
|
29122639 |
2018 |
|
rs2230912
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Its polymorphic variant Gln460Arg has repeatedly been associated with mood disorders.
|
29079688 |
2017 |
|
rs2230912
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Overall, our meta-analysis suggests that P2RX7 gene rs2230912 polymorphism may not contribute to the risk of developing mood disorders using a case-control design.
|
24533115 |
2014 |
|
rs2230912
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In the current study the genetic effects of rs2230912 (Gln460Arg) and rs1653625 (located in the 3' untranslated region of the P2RX7 gene) were explored in mood disorders.
|
23602648 |
2013 |
|
rs2230912
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The same risk alleles predicted more time ill in all cohorts (OR 1.3, 95% CI 1.1-1.6, P = 0.0069 and OR 1.7, 95% CI 1.3-2.3, P = 0.0002 with rs208294 and rs2230912, respectively), so that homozygous carriers spent 12 and 24% more time ill. P2RX7 and its risk alleles predisposed to mood disorders consistently in three independent clinical cohorts.
|
21438144 |
2011 |
|
rs2230912
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our data do not provide support for rs2230912 or the other polymorphisms studied within the P2RX7 locus, being involved in susceptibility to mood disorders.
|
19160446 |
2009 |
|
rs2230912
|
|
|
0.090 |
GeneticVariation |
BEFREE |
When we combined these data with the published case-control studies of P2RX7 and mood disorder (3586 individuals) the association between rs2230912 (Gln460Arg) and affective disorders became more robust (P=0.002).
|
18268501 |
2009 |
|
rs2230912
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Additional studies are needed to clarify the potential involvement of P2RX7 and of SNP rs2230912 in the etiology of major affective disorders.
|
19330776 |
2009 |