Gene: TP53 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs28934578
rs28934578
TP53
T 0.700 CausalMutation CLINVAR

dbSNP: rs1042522
rs1042522
TP53
0.090 GeneticVariation BEFREE Association of the p53 Arg72Pro polymorphism with esophageal cancer in Chinese populations: a meta-analysis. 26345834

2015
dbSNP: rs1042522
rs1042522
TP53
0.090 GeneticVariation BEFREE Modeling gene-environment interactions in oral cavity and esophageal cancers demonstrates a role for the p53 R72P polymorphism in modulating susceptibility. 23475592

2014
dbSNP: rs1042522
rs1042522
TP53
0.090 GeneticVariation BEFREE Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may contributes to EC susceptibility. 25339039

2014
dbSNP: rs1042522
rs1042522
TP53
0.090 GeneticVariation BEFREE In the stratified analysis by ethnicity, the data suggested that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in the Asian group. 23844939

2013
dbSNP: rs1042522
rs1042522
TP53
0.090 GeneticVariation BEFREE Telomeres of patients with minor genotype CC of rs12951053 and GG of rs1042522 were significantly shorter compared to patients with other genotypes of this single nucleotide polymorphism in esophageal cancer tissue. 23124483

2013
dbSNP: rs1042522
rs1042522
TP53
0.090 GeneticVariation BEFREE Crude odds ratios (ORs) with 95% confidence intervals (CIs) were assessed for EC risk associated with TP53 Arg72Pro polymorphism using fixed- and random-effects models. 21448430

2011
dbSNP: rs1042522
rs1042522
TP53
0.090 GeneticVariation BEFREE In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity. 20827430

2010
dbSNP: rs1042522
rs1042522
TP53
0.090 GeneticVariation BEFREE When all 11 studies were pooled into the analysis, an increased esophageal cancer risk was significantly associated with the Pro variant of TP53 Arg72Pro in three genetic comparison models [odds ratio (OR)Pro vs. Arg=1.21, 95% confidence interval (CI): 1.05-1.39, POR=0.009; ORDominant genetic model=1.22, 95% CI: 1.09-1.37, POR=0.001; ORHomozygote model=1.40, 95% CI: 1.05-1.87, POR=0.024]. 20389250

2010
dbSNP: rs1042522
rs1042522
TP53
0.090 GeneticVariation BEFREE In a large prospective cohort, p53 Arg72Pro Pro/Pro was associated with a 2-fold increased risk of death in all esophageal cancers, whereas MDM2 T309G G/G was associated with a 7-fold increased risk of death in squamous cell carcinoma. 19383811

2009
dbSNP: rs1131691014
rs1131691014
TP53
0.080 GeneticVariation BEFREE Association of the p53 Arg72Pro polymorphism with esophageal cancer in Chinese populations: a meta-analysis. 26345834

2015
dbSNP: rs878854066
rs878854066
TP53
0.080 GeneticVariation BEFREE Association of the p53 Arg72Pro polymorphism with esophageal cancer in Chinese populations: a meta-analysis. 26345834

2015
dbSNP: rs1131691014
rs1131691014
TP53
0.080 GeneticVariation BEFREE Modeling gene-environment interactions in oral cavity and esophageal cancers demonstrates a role for the p53 R72P polymorphism in modulating susceptibility. 23475592

2014
dbSNP: rs1131691014
rs1131691014
TP53
0.080 GeneticVariation BEFREE Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may contributes to EC susceptibility. 25339039

2014
dbSNP: rs878854066
rs878854066
TP53
0.080 GeneticVariation BEFREE Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may contributes to EC susceptibility. 25339039

2014
dbSNP: rs878854066
rs878854066
TP53
0.080 GeneticVariation BEFREE Modeling gene-environment interactions in oral cavity and esophageal cancers demonstrates a role for the p53 R72P polymorphism in modulating susceptibility. 23475592

2014
dbSNP: rs1131691014
rs1131691014
TP53
0.080 GeneticVariation BEFREE In the stratified analysis by ethnicity, the data suggested that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in the Asian group. 23844939

2013
dbSNP: rs878854066
rs878854066
TP53
0.080 GeneticVariation BEFREE In the stratified analysis by ethnicity, the data suggested that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in the Asian group. 23844939

2013
dbSNP: rs1131691014
rs1131691014
TP53
0.080 GeneticVariation BEFREE Crude odds ratios (ORs) with 95% confidence intervals (CIs) were assessed for EC risk associated with TP53 Arg72Pro polymorphism using fixed- and random-effects models. 21448430

2011
dbSNP: rs878854066
rs878854066
TP53
0.080 GeneticVariation BEFREE Crude odds ratios (ORs) with 95% confidence intervals (CIs) were assessed for EC risk associated with TP53 Arg72Pro polymorphism using fixed- and random-effects models. 21448430

2011
dbSNP: rs1131691014
rs1131691014
TP53
0.080 GeneticVariation BEFREE In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity. 20827430

2010
dbSNP: rs1131691014
rs1131691014
TP53
0.080 GeneticVariation BEFREE When all 11 studies were pooled into the analysis, an increased esophageal cancer risk was significantly associated with the Pro variant of TP53 Arg72Pro in three genetic comparison models [odds ratio (OR)Pro vs. Arg=1.21, 95% confidence interval (CI): 1.05-1.39, POR=0.009; ORDominant genetic model=1.22, 95% CI: 1.09-1.37, POR=0.001; ORHomozygote model=1.40, 95% CI: 1.05-1.87, POR=0.024]. 20389250

2010
dbSNP: rs878854066
rs878854066
TP53
0.080 GeneticVariation BEFREE When all 11 studies were pooled into the analysis, an increased esophageal cancer risk was significantly associated with the Pro variant of TP53 Arg72Pro in three genetic comparison models [odds ratio (OR)Pro vs. Arg=1.21, 95% confidence interval (CI): 1.05-1.39, POR=0.009; ORDominant genetic model=1.22, 95% CI: 1.09-1.37, POR=0.001; ORHomozygote model=1.40, 95% CI: 1.05-1.87, POR=0.024]. 20389250

2010
dbSNP: rs878854066
rs878854066
TP53
0.080 GeneticVariation BEFREE In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity. 20827430

2010
dbSNP: rs1131691014
rs1131691014
TP53
0.080 GeneticVariation BEFREE In a large prospective cohort, p53 Arg72Pro Pro/Pro was associated with a 2-fold increased risk of death in all esophageal cancers, whereas MDM2 T309G G/G was associated with a 7-fold increased risk of death in squamous cell carcinoma. 19383811

2009