|
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The mechanisms of adrenal tumorigenesis remain poorly established; the R337H germline mutation in the p53 gene has previously been associated with ACTs in Brazilian children.
|
15952083 |
2005 |
|
rs28934576
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Heterozygous p53(R270H/+)WAPCre mice (with mammary gland-specific expression of the p53.R270H mutation, equivalent to human R273H, at physiologic levels) develop mammary tumors at high frequency, indicating that the R270H mutation predisposes for mammary gland tumor development and acts in a dominant-negative manner in early stages of tumorigenesis.
|
16166291 |
2005 |
|
rs28934576
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This study has investigated the impact of three specific dominant-negative p53 mutants (F134L, M237L, and R273H) on tumorigenesis by LNCaP prostate cancer cells.
|
16723121 |
2006 |
|
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Moreover, loss of heterozygocity with retention of the R337H allele was observed in a breast adenocarcinoma, supporting a role for this mutation in breast tumorigenesis.
|
16494995 |
2007 |
|
rs121912651
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Several lines of evidence further indicate gain-of-function of p53 mutants in promoting tumorigenesis. p53(R248W) mice rapidly succumb to certain types of cancers not commonly observed in p53(-/-) mice.
|
17417627 |
2007 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process.
|
18068527 |
2008 |
|
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process.
|
18068527 |
2008 |
|
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, other tumor types, mainly breast cancer, have been observed in carriers of several unrelated kindreds, raising the possibility that the R337H mutation may also contribute to breast tumorigenesis in a genetic background-specific context.
|
19046423 |
2008 |
|
rs878854066
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process.
|
18068527 |
2008 |
|
rs1057519747
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mice with a germ line p53 mutation (p53(Ala135Val/wt)) display increased susceptibility to lung, skin, and colon carcinogenesis.
|
18234966 |
2008 |
|
rs121912665
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mice with a germ line p53 mutation (p53(Ala135Val/wt)) display increased susceptibility to lung, skin, and colon carcinogenesis.
|
18234966 |
2008 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
These findings suggest that under at least some conditions, the modulation of apoptosis by the R72P polymorphism does not affect the process of carcinogenesis.
|
20587514 |
2010 |
|
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These findings suggest that under at least some conditions, the modulation of apoptosis by the R72P polymorphism does not affect the process of carcinogenesis.
|
20587514 |
2010 |
|
rs878854066
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These findings suggest that under at least some conditions, the modulation of apoptosis by the R72P polymorphism does not affect the process of carcinogenesis.
|
20587514 |
2010 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis.
|
21976716 |
2012 |
|
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis.
|
21976716 |
2012 |
|
rs878854066
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis.
|
21976716 |
2012 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The effect of NO-aspirin on pancreatic carcinogenesis was investigated by assessing the development of precursor pancreatic lesions and adenocarcinomas in Kras(G12D/+) transgenic mice that recapitulate human pancreatic cancer progression.
|
23019409 |
2012 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Similar thus inconclusive results are observed in ovarian cancer, which may suggest that the rs1042522 does not influence ovarian carcinogenesis directly, but might be linked to another pathogenic alteration.
|
23192612 |
2013 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Kras(G12D); IL-6(-/-) mice exhibited increased tumorigenesis, but slower tumor growth and longer survival, than Kras(G12D) mice.
|
24260500 |
2013 |
|
rs730882025
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that the natural variants, E6 D25E and L83V, similar to the prototype E6 protein, contribute to tumorigenesis by degrading p53.
|
23404471 |
2013 |
|
rs863224683
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that the natural variants, E6 D25E and L83V, similar to the prototype E6 protein, contribute to tumorigenesis by degrading p53.
|
23404471 |
2013 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.
|
24326769 |
2014 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These results suggest that tsTAg synergistically promotes Kras(G12D) -associated PDAC formation, and our study identifies a new mouse model of PDAC that may allow a better understanding of the mechanism of carcinogenesis in pancreatic carcinoma, which shows a catastrophic clinical course.
|
25042889 |
2014 |
|
rs863224682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The above results suggest that an FGFR3 p.R248H mutation is involved in the carcinogenesis of a subset of LCs and may contribute to the elucidation of the characteristics of FGFR3 mutation-positive LCs in the future.
|
24452392 |
2014 |