|
rs121912660
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The K120R mutation renders the p53 protein disabled for acetylation and, as a result, defective for apoptotic function, which provides a mechanistic link between the missense mutation and tumorigenesis.
|
30348990 |
2019 |
|
rs764803020
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The K120R mutation renders the p53 protein disabled for acetylation and, as a result, defective for apoptotic function, which provides a mechanistic link between the missense mutation and tumorigenesis.
|
30348990 |
2019 |
|
rs781490101
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The K120R mutation renders the p53 protein disabled for acetylation and, as a result, defective for apoptotic function, which provides a mechanistic link between the missense mutation and tumorigenesis.
|
30348990 |
2019 |
|
rs28934575
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results indicate that mutant TP53 G245C and R273H can lead to more aggressive phenotypes and enhance cancer cell malignancy, which further uncover TP53 function in carcinogenesis and might be useful in clinical diagnosis and therapy of TP53 mutant cancers.
|
30126368 |
2018 |
|
rs573154688
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>De novo</i> tumorigenesis was not significantly increased in either heterozygous (<i>p53<sup>334R/H</sup></i> ) or homozygous (<i>p53<sup>334H/H</sup></i> ) p53 R334H knockin mice compared with wild-type mice.
|
30042151 |
2018 |
|
rs771939956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>De novo</i> tumorigenesis was not significantly increased in either heterozygous (<i>p53<sup>334R/H</sup></i> ) or homozygous (<i>p53<sup>334H/H</sup></i> ) p53 R334H knockin mice compared with wild-type mice.
|
30042151 |
2018 |
|
rs779196500
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, we found that the L104P mutation in the VCX gene (Variable charge, X-linked) was absent in white blood cell samples, but present at 11.1% frequency in the adjacent tissues and increased to 14.6% in HCC tissues, suggesting that this mutation might be a tumor driver gene driving HCC carcinogenesis.
|
28412734 |
2017 |
|
rs942158624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When the role of SCF<sup>Skp2/Cks1</sup>-mediated p27 ubiquitination in cancer was specifically tested by p27 Thr187-to-Ala knockin (p27T187A KI), it was found dispensable for Kras<sup>G12D</sup>-induced lung tumorigenesis but essential for Rb1-deficient pituitary tumorigenesis.
|
27181203 |
2017 |
|
rs1131691021
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Co-expression of Nm23H1 but not H2 in NIH3T3 cells effectively suppressed neoplastic transformation and tumorigenesis induced by the oncogenic H-Ras G12V mutant.
|
25748386 |
2015 |
|
rs863224682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The above results suggest that an FGFR3 p.R248H mutation is involved in the carcinogenesis of a subset of LCs and may contribute to the elucidation of the characteristics of FGFR3 mutation-positive LCs in the future.
|
24452392 |
2014 |
|
rs879253942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The role of folic acid in carcinogenesis may be modulated by polymorphism C677T in MTHFR and tandem repeats 2R/3R in the promoter site of TYMS gene that are related to decreased enzymatic activity and quantity and availability of the enzyme, respectively.
|
25341694 |
2014 |
|
rs730882025
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that the natural variants, E6 D25E and L83V, similar to the prototype E6 protein, contribute to tumorigenesis by degrading p53.
|
23404471 |
2013 |
|
rs863224683
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that the natural variants, E6 D25E and L83V, similar to the prototype E6 protein, contribute to tumorigenesis by degrading p53.
|
23404471 |
2013 |
|
rs1057519747
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mice with a germ line p53 mutation (p53(Ala135Val/wt)) display increased susceptibility to lung, skin, and colon carcinogenesis.
|
18234966 |
2008 |
|
rs121912665
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mice with a germ line p53 mutation (p53(Ala135Val/wt)) display increased susceptibility to lung, skin, and colon carcinogenesis.
|
18234966 |
2008 |
|
rs121912651
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Several lines of evidence further indicate gain-of-function of p53 mutants in promoting tumorigenesis. p53(R248W) mice rapidly succumb to certain types of cancers not commonly observed in p53(-/-) mice.
|
17417627 |
2007 |
|
rs11540652
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study investigated regulators of mutant TP53 (R248Q) in basal-like TNBC and their impact on tumorigenesis.
|
30349649 |
2018 |
|
rs11540652
|
|
|
0.020 |
GeneticVariation |
BEFREE |
P53 mutation plays a pivotal role in tumorigenesis of endometrial cancer (EC), here we report that the gain-of-function mutant p53-R248Q targets the proteasome activator REGγ to promote EC progression.
|
25697482 |
2015 |
|
rs28934576
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These results indicate that mutant TP53 G245C and R273H can lead to more aggressive phenotypes and enhance cancer cell malignancy, which further uncover TP53 function in carcinogenesis and might be useful in clinical diagnosis and therapy of TP53 mutant cancers.
|
30126368 |
2018 |
|
rs28934576
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In the current study, the combined loss of PAX2 and expression of the R273H p53 mutant protein in murine oviductal epithelial (MOE) cells enhanced proliferation and growth in soft agar in vitro but was insufficient to drive tumorigenesis in vivo.
|
27991925 |
2017 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Co-expression of Nm23H1 but not H2 in NIH3T3 cells effectively suppressed neoplastic transformation and tumorigenesis induced by the oncogenic H-Ras G12V mutant.
|
25748386 |
2015 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These results suggest that tsTAg synergistically promotes Kras(G12D) -associated PDAC formation, and our study identifies a new mouse model of PDAC that may allow a better understanding of the mechanism of carcinogenesis in pancreatic carcinoma, which shows a catastrophic clinical course.
|
25042889 |
2014 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Kras(G12D); IL-6(-/-) mice exhibited increased tumorigenesis, but slower tumor growth and longer survival, than Kras(G12D) mice.
|
24260500 |
2013 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The effect of NO-aspirin on pancreatic carcinogenesis was investigated by assessing the development of precursor pancreatic lesions and adenocarcinomas in Kras(G12D/+) transgenic mice that recapitulate human pancreatic cancer progression.
|
23019409 |
2012 |
|
rs28934576
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This study has investigated the impact of three specific dominant-negative p53 mutants (F134L, M237L, and R273H) on tumorigenesis by LNCaP prostate cancer cells.
|
16723121 |
2006 |