|
rs573154688
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>De novo</i> tumorigenesis was not significantly increased in either heterozygous (<i>p53<sup>334R/H</sup></i> ) or homozygous (<i>p53<sup>334H/H</sup></i> ) p53 R334H knockin mice compared with wild-type mice.
|
30042151 |
2018 |
|
rs771939956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>De novo</i> tumorigenesis was not significantly increased in either heterozygous (<i>p53<sup>334R/H</sup></i> ) or homozygous (<i>p53<sup>334H/H</sup></i> ) p53 R334H knockin mice compared with wild-type mice.
|
30042151 |
2018 |
|
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
By modeling a <i>TP53</i> mutation in mice that has relatively weak cancer penetrance, this study provides <i>in vivo</i> evidence that the human R337H mutation can compromise p53 activity and promote tumorigenesis.<b>Significance:</b> A germline mutation in the oligomerization domain of p53 decreases its transactivation potential and renders mice susceptible to carcinogen-induced liver tumorigenesis.<i></i>.
|
30042151 |
2018 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Co-expression of Nm23H1 but not H2 in NIH3T3 cells effectively suppressed neoplastic transformation and tumorigenesis induced by the oncogenic H-Ras G12V mutant.
|
25748386 |
2015 |
|
rs1131691021
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Co-expression of Nm23H1 but not H2 in NIH3T3 cells effectively suppressed neoplastic transformation and tumorigenesis induced by the oncogenic H-Ras G12V mutant.
|
25748386 |
2015 |
|
rs28934576
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Heterozygous p53(R270H/+)WAPCre mice (with mammary gland-specific expression of the p53.R270H mutation, equivalent to human R273H, at physiologic levels) develop mammary tumors at high frequency, indicating that the R270H mutation predisposes for mammary gland tumor development and acts in a dominant-negative manner in early stages of tumorigenesis.
|
16166291 |
2005 |
|
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, other tumor types, mainly breast cancer, have been observed in carriers of several unrelated kindreds, raising the possibility that the R337H mutation may also contribute to breast tumorigenesis in a genetic background-specific context.
|
19046423 |
2008 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process.
|
18068527 |
2008 |
|
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process.
|
18068527 |
2008 |
|
rs878854066
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process.
|
18068527 |
2008 |
|
rs779196500
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, we found that the L104P mutation in the VCX gene (Variable charge, X-linked) was absent in white blood cell samples, but present at 11.1% frequency in the adjacent tissues and increased to 14.6% in HCC tissues, suggesting that this mutation might be a tumor driver gene driving HCC carcinogenesis.
|
28412734 |
2017 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis.
|
21976716 |
2012 |
|
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis.
|
21976716 |
2012 |
|
rs878854066
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis.
|
21976716 |
2012 |
|
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In conclusion, the R337H mutation has significant predictive and prognostic value and is associated with tumorigenesis of the adrenal cortex.
|
26681051 |
2015 |
|
rs28934576
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In the current study, the combined loss of PAX2 and expression of the R273H p53 mutant protein in murine oviductal epithelial (MOE) cells enhanced proliferation and growth in soft agar in vitro but was insufficient to drive tumorigenesis in vivo.
|
27991925 |
2017 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
It is evident from our study that Arg72Pro SNP of TP53 gene is connected with higher susceptibility to thyroid cancer especially in young age group, female gender, non-smokers and patients with elevated TSH levels, hence, implicated in thyroid carcinogenesis.
|
25835179 |
2015 |
|
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
It is evident from our study that Arg72Pro SNP of TP53 gene is connected with higher susceptibility to thyroid cancer especially in young age group, female gender, non-smokers and patients with elevated TSH levels, hence, implicated in thyroid carcinogenesis.
|
25835179 |
2015 |
|
rs878854066
|
|
|
0.050 |
GeneticVariation |
BEFREE |
It is evident from our study that Arg72Pro SNP of TP53 gene is connected with higher susceptibility to thyroid cancer especially in young age group, female gender, non-smokers and patients with elevated TSH levels, hence, implicated in thyroid carcinogenesis.
|
25835179 |
2015 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Kras(G12D); IL-6(-/-) mice exhibited increased tumorigenesis, but slower tumor growth and longer survival, than Kras(G12D) mice.
|
24260500 |
2013 |
|
rs1057519747
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mice with a germ line p53 mutation (p53(Ala135Val/wt)) display increased susceptibility to lung, skin, and colon carcinogenesis.
|
18234966 |
2008 |
|
rs121912665
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mice with a germ line p53 mutation (p53(Ala135Val/wt)) display increased susceptibility to lung, skin, and colon carcinogenesis.
|
18234966 |
2008 |
|
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Moreover, loss of heterozygocity with retention of the R337H allele was observed in a breast adenocarcinoma, supporting a role for this mutation in breast tumorigenesis.
|
16494995 |
2007 |
|
rs11540652
|
|
|
0.020 |
GeneticVariation |
BEFREE |
P53 mutation plays a pivotal role in tumorigenesis of endometrial cancer (EC), here we report that the gain-of-function mutant p53-R248Q targets the proteasome activator REGγ to promote EC progression.
|
25697482 |
2015 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.
|
24326769 |
2014 |