|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
It is evident from our study that Arg72Pro SNP of TP53 gene is connected with higher susceptibility to thyroid cancer especially in young age group, female gender, non-smokers and patients with elevated TSH levels, hence, implicated in thyroid carcinogenesis.
|
25835179 |
2015 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Similar thus inconclusive results are observed in ovarian cancer, which may suggest that the rs1042522 does not influence ovarian carcinogenesis directly, but might be linked to another pathogenic alteration.
|
23192612 |
2013 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis.
|
21976716 |
2012 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.
|
24326769 |
2014 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
These findings suggest that under at least some conditions, the modulation of apoptosis by the R72P polymorphism does not affect the process of carcinogenesis.
|
20587514 |
2010 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
So, as to find the association of p53Arg <sup>72</sup> Pro towards lung carcinogenesis and overall survival of North Indian lung cancer patients, single nucleotide polymorphic variant (rs1042522) was analyzed.
|
27614750 |
2016 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process.
|
18068527 |
2008 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We conducted a case-control study to examine whether two polymorphisms (i.e., rs4938723 in the promoter of pri-miR-34b/c and TP53 Arg72Pro) were linked to the carcinogenesis of cervical cancer among Chinese Han women.
|
26619844 |
2016 |
|
rs1057519747
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mice with a germ line p53 mutation (p53(Ala135Val/wt)) display increased susceptibility to lung, skin, and colon carcinogenesis.
|
18234966 |
2008 |
|
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We conducted a case-control study to examine whether two polymorphisms (i.e., rs4938723 in the promoter of pri-miR-34b/c and TP53 Arg72Pro) were linked to the carcinogenesis of cervical cancer among Chinese Han women.
|
26619844 |
2016 |
|
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process.
|
18068527 |
2008 |
|
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These findings suggest that under at least some conditions, the modulation of apoptosis by the R72P polymorphism does not affect the process of carcinogenesis.
|
20587514 |
2010 |
|
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis.
|
21976716 |
2012 |
|
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
It is evident from our study that Arg72Pro SNP of TP53 gene is connected with higher susceptibility to thyroid cancer especially in young age group, female gender, non-smokers and patients with elevated TSH levels, hence, implicated in thyroid carcinogenesis.
|
25835179 |
2015 |
|
rs1131691021
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Co-expression of Nm23H1 but not H2 in NIH3T3 cells effectively suppressed neoplastic transformation and tumorigenesis induced by the oncogenic H-Ras G12V mutant.
|
25748386 |
2015 |
|
rs11540652
|
|
|
0.020 |
GeneticVariation |
BEFREE |
P53 mutation plays a pivotal role in tumorigenesis of endometrial cancer (EC), here we report that the gain-of-function mutant p53-R248Q targets the proteasome activator REGγ to promote EC progression.
|
25697482 |
2015 |
|
rs11540652
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study investigated regulators of mutant TP53 (R248Q) in basal-like TNBC and their impact on tumorigenesis.
|
30349649 |
2018 |
|
rs121912651
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Several lines of evidence further indicate gain-of-function of p53 mutants in promoting tumorigenesis. p53(R248W) mice rapidly succumb to certain types of cancers not commonly observed in p53(-/-) mice.
|
17417627 |
2007 |
|
rs121912660
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The K120R mutation renders the p53 protein disabled for acetylation and, as a result, defective for apoptotic function, which provides a mechanistic link between the missense mutation and tumorigenesis.
|
30348990 |
2019 |
|
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The mechanisms of adrenal tumorigenesis remain poorly established; the R337H germline mutation in the p53 gene has previously been associated with ACTs in Brazilian children.
|
15952083 |
2005 |
|
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Moreover, loss of heterozygocity with retention of the R337H allele was observed in a breast adenocarcinoma, supporting a role for this mutation in breast tumorigenesis.
|
16494995 |
2007 |
|
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
By modeling a <i>TP53</i> mutation in mice that has relatively weak cancer penetrance, this study provides <i>in vivo</i> evidence that the human R337H mutation can compromise p53 activity and promote tumorigenesis.<b>Significance:</b> A germline mutation in the oligomerization domain of p53 decreases its transactivation potential and renders mice susceptible to carcinogen-induced liver tumorigenesis.<i></i>.
|
30042151 |
2018 |
|
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In conclusion, the R337H mutation has significant predictive and prognostic value and is associated with tumorigenesis of the adrenal cortex.
|
26681051 |
2015 |
|
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, other tumor types, mainly breast cancer, have been observed in carriers of several unrelated kindreds, raising the possibility that the R337H mutation may also contribute to breast tumorigenesis in a genetic background-specific context.
|
19046423 |
2008 |
|
rs121912665
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mice with a germ line p53 mutation (p53(Ala135Val/wt)) display increased susceptibility to lung, skin, and colon carcinogenesis.
|
18234966 |
2008 |