rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
So, as to find the association of p53Arg <sup>72</sup> Pro towards lung carcinogenesis and overall survival of North Indian lung cancer patients, single nucleotide polymorphic variant (rs1042522) was analyzed.
|
27614750 |
2016 |
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We conducted a case-control study to examine whether two polymorphisms (i.e., rs4938723 in the promoter of pri-miR-34b/c and TP53 Arg72Pro) were linked to the carcinogenesis of cervical cancer among Chinese Han women.
|
26619844 |
2016 |
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
It is evident from our study that Arg72Pro SNP of TP53 gene is connected with higher susceptibility to thyroid cancer especially in young age group, female gender, non-smokers and patients with elevated TSH levels, hence, implicated in thyroid carcinogenesis.
|
25835179 |
2015 |
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.
|
24326769 |
2014 |
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Similar thus inconclusive results are observed in ovarian cancer, which may suggest that the rs1042522 does not influence ovarian carcinogenesis directly, but might be linked to another pathogenic alteration.
|
23192612 |
2013 |
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis.
|
21976716 |
2012 |
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
These findings suggest that under at least some conditions, the modulation of apoptosis by the R72P polymorphism does not affect the process of carcinogenesis.
|
20587514 |
2010 |
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process.
|
18068527 |
2008 |