Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2234693
rs2234693
0.050 GeneticVariation BEFREE Studies on the association between two single nucleotide polymorphisms (SNPs) in estrogen receptor α (ERα), PvuII (rs2234693 T>C) and XbaI (rs9340799 A>G), and the prostate cancer risk are inconsistent. 28721070

2017

dbSNP: rs2234693
rs2234693
0.050 GeneticVariation BEFREE The meta-analysis indicated that ESRα rs9340799 and rs2234693 might contribute to susceptibility and development of PC in European population. 29254246

2017

dbSNP: rs9340799
rs9340799
0.050 GeneticVariation BEFREE Studies on the association between two single nucleotide polymorphisms (SNPs) in estrogen receptor α (ERα), PvuII (rs2234693 T>C) and XbaI (rs9340799 A>G), and the prostate cancer risk are inconsistent. 28721070

2017

dbSNP: rs9340799
rs9340799
0.050 GeneticVariation BEFREE The meta-analysis indicated that ESRα rs9340799 and rs2234693 might contribute to susceptibility and development of PC in European population. 29254246

2017

dbSNP: rs2234693
rs2234693
0.050 GeneticVariation BEFREE However, there was no significant association between ESR1 rs2234693 and PCa risk. 26251204

2015

dbSNP: rs9340799
rs9340799
0.050 GeneticVariation BEFREE In conclusion, this meta-analysis indicated that ESR1 rs9340799 polymorphism was associated with prosta</span>te cancer risk in overall populations, Caucasians and Africans, while ESR2 rs1256049 polymorphism was associated with prostate cancer risk in Caucasians. 24859835

2014

dbSNP: rs2234693
rs2234693
0.050 GeneticVariation BEFREE Estrogen receptors alpha (rs2234693 and rs9340799), and beta (rs4986938 and rs1256049) genes polymorphism in prostate cancer: evidence for association with risk and histopathological tumor characteristics in Iranian men. 22228197

2012

dbSNP: rs2234693
rs2234693
0.050 GeneticVariation BEFREE These data suggested that variant rs9340799, but not rs2234693, on ESR1 confers an elevated risk of prostate cancer. 23098495

2012

dbSNP: rs9340799
rs9340799
0.050 GeneticVariation BEFREE For rs9340799, heterozygosity of T/C carriers showed a significant increased prostate cancer risk with a pooled odds ratio (OR) of 1.34 (95% CI = 1.06-1.69) while homozygote C/C carriers showed an increased but not statistically significant association with prostate cancer risk (pooled OR = 1.29, 95% CI = 0.94-1.79). 23098495

2012

dbSNP: rs9340799
rs9340799
0.050 GeneticVariation BEFREE Estrogen receptors alpha (rs2234693 and rs9340799), and beta (rs4986938 and rs1256049) genes polymorphism in prostate cancer: evidence for association with risk and histopathological tumor characteristics in Iranian men. 22228197

2012

dbSNP: rs2077647
rs2077647
0.020 GeneticVariation BEFREE The present study suggests that rs2077647 polymorphism may be a risk factor for prostate cancer especially in patients diagnosed before the age of 60, while rs3798577 polymorphism could probably serve rather as promoting factor in combination with other polymorphisms in estrogen receptor alpha contributing preferably to development of high-grade carcinomas. 25828708

2015

dbSNP: rs2077647
rs2077647
0.020 GeneticVariation BEFREE The combination of the TTTA long repeats and the minor alleles of rs10046 in CYP19A1 and rs2077647 in ESR-alpha was a high risk for prostate cancer despite greater than or equal to 60 mg isoflavones/day. 19952760

2010

dbSNP: rs3798577
rs3798577
0.010 GeneticVariation BEFREE The present study suggests that rs2077647 polymorphism may be a risk factor for prostate cancer especially in patients diagnosed before the age of 60, while rs3798577 polymorphism could probably serve rather as promoting factor in combination with other polymorphisms in estrogen receptor alpha contributing preferably to development of high-grade carcinomas. 25828708

2015

dbSNP: rs2228480
rs2228480
0.010 GeneticVariation BEFREE An interaction between intake level of phytoestrogen and genotypes of ESR1 Ex1-192G>C (rs746432) and between intake level of phytoestrogen and genotypes of ESR1 Ex8+229G>A (rs2228480) and risk of prostate cancer was observed (p = 0.0009 and p = 0.044, respectively). 19654868

2009

dbSNP: rs746432
rs746432
0.010 GeneticVariation BEFREE An interaction between intake level of phytoestrogen and genotypes of ESR1 Ex1-192G>C (rs746432) and between intake level of phytoestrogen and genotypes of ESR1 Ex8+229G>A (rs2228480) and risk of prostate cancer was observed (p = 0.0009 and p = 0.044, respectively). 19654868

2009